Combining Timelapse Imaging And Computational Modelling To Understand The Mechanisms Of Axon Guidance In The Developing Retinotectal System
Funder
National Health and Medical Research Council
Funding Amount
$438,793.00
Summary
Understanding how patterns of brain wiring develop is crucial for understanding many cognitive disorders. One of the commonest types of connection pattern in the brain is a topographic map, where nearby neurons in one structure connect to nearby neurons in another structure. Using the transgenic tools available in the zebrafish as a model system, we will combine novel experiments with computational modelling to understand the rules which govern the formation of topographic maps in the brain.
Computational Analysis Of The Influence Of Growth Cone Shape Dynamics On Axon Guidance
Funder
National Health and Medical Research Council
Funding Amount
$346,406.00
Summary
For the brain to function correctly its neurons must be connected correctly. This project will use a novel mathematical approach to understand how growing nerve fibres find where to go in the developing brain. In particular we will use both experiments and computational analysis to understand how the shape of the tip of a growing nerve fibre helps the fibre navigate. This may help us understand the biological cause of many different types of mental disorders.