Patient-specific Computational Tools for Diagnosing and Treating Gait Disorders in Children with Cerebral Palsy. This proposal addresses one of the most fundamental and difficult questions related to the treatment of children with cerebral palsy: Why do these children walk in a crouched position, with excessively bent hips and knees? High-fidelity, patient-specific computer simulations of walking can help to answer this question and, in so doing, can improve the outcomes of orthopaedic surgeries ....Patient-specific Computational Tools for Diagnosing and Treating Gait Disorders in Children with Cerebral Palsy. This proposal addresses one of the most fundamental and difficult questions related to the treatment of children with cerebral palsy: Why do these children walk in a crouched position, with excessively bent hips and knees? High-fidelity, patient-specific computer simulations of walking can help to answer this question and, in so doing, can improve the outcomes of orthopaedic surgeries designed to correct movement abnormalities in these patients. Realistic computer simulations of human movement can play a pivotal role in healthcare through patient rehabilitation; in sports, through the development of personalized training programs for elite athletes; and in entertainment, through the creation of video games and animated films.Read moreRead less
Joint System Identification for Point Processes and Time-series. In various application areas such as neurophysiology, earthquake modeling, price spikes in electricity markets, the data of interest are point processes (aka sequences of events) or combinations of point processes and analog signals. To understand the underlying subject of interest we need to be able to extract the maximum information from these observation sequences. The current tools for doing this are very limited. This resear ....Joint System Identification for Point Processes and Time-series. In various application areas such as neurophysiology, earthquake modeling, price spikes in electricity markets, the data of interest are point processes (aka sequences of events) or combinations of point processes and analog signals. To understand the underlying subject of interest we need to be able to extract the maximum information from these observation sequences. The current tools for doing this are very limited. This research program will develop the complex signal processing and system methodology needed to create a suitable tool set.Read moreRead less
Efficient Algorithms for Multiple Object Filtering using Stochastic Geometry. The outcomes of this project will enhance our ability to harness advances in sensing and computing technologies and develop automated systems which facilitate rapid and reliable detection and monitoring of potential threats in our air, sea, and land space. Such systems assist our defence personnel in the event of a threat to implement measured and effective responses, and ultimately enhance Australia's operational adva ....Efficient Algorithms for Multiple Object Filtering using Stochastic Geometry. The outcomes of this project will enhance our ability to harness advances in sensing and computing technologies and develop automated systems which facilitate rapid and reliable detection and monitoring of potential threats in our air, sea, and land space. Such systems assist our defence personnel in the event of a threat to implement measured and effective responses, and ultimately enhance Australia's operational advantage, in line with the national research priority of 'Safeguarding Australia' and its associated priority goals. The developed technologies also have significant commercial potential which benefit Australian industries in areas such as robotics, automotive safety and biomedical engineering.Read moreRead less
Performance evaluation and characterisation for filtering in multi-object system. The project falls within the National Research Priority of 'Safeguarding Australia' and associated research priority goal of 'Transforming Defence Technology'. The project outcomes will provide cutting edge technology in surveillance, and monitoring of potential threat in our air, sea, and land space. Fast, reliable information enable our personnel to make timely, intelligent judgements, and appropriate responses i ....Performance evaluation and characterisation for filtering in multi-object system. The project falls within the National Research Priority of 'Safeguarding Australia' and associated research priority goal of 'Transforming Defence Technology'. The project outcomes will provide cutting edge technology in surveillance, and monitoring of potential threat in our air, sea, and land space. Fast, reliable information enable our personnel to make timely, intelligent judgements, and appropriate responses in the event of a threat, thereby maintaining Australia's operational advantage. Other application areas that benefits from our research include radar, sonar, guidance, navigation, air traffic control, image processing, oceanography, autonomous vehicles and robotics, remote sensing, and biomedical research.
Read moreRead less
Communication and information storage mechanisms in complex dynamical brain networks. Recordings of electrical activity in the brain often cycle repetitively. The aim of this research is to explain how these brain rhythms assist the brain to coordinate simultaneous activity in several regions. Australian socioeconomic benefits include: (i) contributions to the knowledge base of theoretical neuroscience, enhancing Australia's reputation for cutting-edge research; (ii) strengthening of internation ....Communication and information storage mechanisms in complex dynamical brain networks. Recordings of electrical activity in the brain often cycle repetitively. The aim of this research is to explain how these brain rhythms assist the brain to coordinate simultaneous activity in several regions. Australian socioeconomic benefits include: (i) contributions to the knowledge base of theoretical neuroscience, enhancing Australia's reputation for cutting-edge research; (ii) strengthening of international collaborations with Europe and Japan; (iii) outcomes will ultimately impact on improved medical bionics and future interfaces between brain activity and machines or computers; and (iv) commercialization and technology transfer opportunities, via the transfer of results to biologically inspired engineering.Read moreRead less
Modelling and estimation techniques for the transmission and control of Tuberculosis with new and existing vaccines. Most Tuberculosis in Australia is seen in foreign-born people. Australia has an important role in providing leadership in the Asia-Pacific region in Tuberculosis control, which will have flow-on benefits to TB control in this country. Using mathematical models, this project will assess the use of vaccines for Tuberculosis in the developing world. Rising levels of extremely drug r ....Modelling and estimation techniques for the transmission and control of Tuberculosis with new and existing vaccines. Most Tuberculosis in Australia is seen in foreign-born people. Australia has an important role in providing leadership in the Asia-Pacific region in Tuberculosis control, which will have flow-on benefits to TB control in this country. Using mathematical models, this project will assess the use of vaccines for Tuberculosis in the developing world. Rising levels of extremely drug resistant infections make this a timely and important study with significant policy implications, both externally and in the Australian context. Read moreRead less
Dynamic risk measures. Exposure to risk is a pervasive problem. The results will be of importance for financial institutions when they estimate their exposure to risk. Other applications will be to determine the level of risk from a terrorist attack or regional instability. Companies wish to allocate resources to minimize their exposure to adverse events.
Multi-scale modelling of cell migration in developmental biology. Interpretative and predictive tools are needed for the comprehensive understanding of directed cell migration in the medical sciences. Mathematical models and modelling methodologies developed in this project will make a significant contribution to the investigation of cell migration and the testing and generation of hypotheses. Such models are needed to understand observed cellular patterns. This project will contribute to knowle ....Multi-scale modelling of cell migration in developmental biology. Interpretative and predictive tools are needed for the comprehensive understanding of directed cell migration in the medical sciences. Mathematical models and modelling methodologies developed in this project will make a significant contribution to the investigation of cell migration and the testing and generation of hypotheses. Such models are needed to understand observed cellular patterns. This project will contribute to knowledge of normal and abnormal developmental processes, especially in embryonic growth. Understanding these processes should lead to prediction and treatment of congenital disorders and contribute to a healthy start to life.Read moreRead less
Mathematical modelling of information flow in social networks. This proposal aims to develop new mathematical and statistical methods to understand information flow in social networks. By using novel information theoretic techniques, it will create new methods to characterise social information flow in social networks. These tools will allow derivation of fundamental limits of predictability for AI methods applied to digital data. New mathematics of information flow will produce insights into so ....Mathematical modelling of information flow in social networks. This proposal aims to develop new mathematical and statistical methods to understand information flow in social networks. By using novel information theoretic techniques, it will create new methods to characterise social information flow in social networks. These tools will allow derivation of fundamental limits of predictability for AI methods applied to digital data. New mathematics of information flow will produce insights into social influence in online social networks. Benefits include: better understanding of how echo chambers may form in social networks, predictive models for how misinformation can spread online such as during an emergency, and a framework for intercomparison of AI methods applied to digital data on individuals. Read moreRead less
Mathematical models of diseases with complex transmission routes. This project aims to model diseases that spread via a mixture of routes including food, water, the environment, and direct spread between individuals. Key diseases include: avian influenza, which causes massive disruption to the poultry industry; gastroenteritis, which costs Australia $1,250 million each year; and leptospirosis, which causes one million severe illnesses each year globally. This project will develop mathematical a ....Mathematical models of diseases with complex transmission routes. This project aims to model diseases that spread via a mixture of routes including food, water, the environment, and direct spread between individuals. Key diseases include: avian influenza, which causes massive disruption to the poultry industry; gastroenteritis, which costs Australia $1,250 million each year; and leptospirosis, which causes one million severe illnesses each year globally. This project will develop mathematical and statistical tools to better estimate risk, analyse outbreak data, and provide guidance for disease control. This research will improve policy and enhance our ability to respond to disease outbreaks.Read moreRead less