Improving Oocyte Mitochondrial DNA Copy Number To Enhance Female Reproductive Capacity.
Funder
National Health and Medical Research Council
Funding Amount
$670,867.00
Summary
Eggs with too few copies of mitochondrial DNA either fail to fertilise or arrest during early development. By supplementing eggs with mitochondrial DNA, we have been able to enhance embryo quality and gene expression profiles. By breeding the offspring derived from eggs given mitochondrial supplementation, we will determine if they and their progeny meet normal developmental milestones, regulate the transmission of mitochondrial DNA appropriately, and are healthy and fertile.
Regulation of tissue morphogenesis in reproductive function and metastatic cancer. Infertility, endocrine and metabolic disorders and reproductive cancers are all increasing medical problems and principal contributors to morbidity and mortality in the Australian community. This research takes the novel approach of investigating the mechanisms of dynamic remodeling in reproductive organs. Novel hormonally controlled mechanisms of tissue remodeling unique to reproductive organs and cancers in ad ....Regulation of tissue morphogenesis in reproductive function and metastatic cancer. Infertility, endocrine and metabolic disorders and reproductive cancers are all increasing medical problems and principal contributors to morbidity and mortality in the Australian community. This research takes the novel approach of investigating the mechanisms of dynamic remodeling in reproductive organs. Novel hormonally controlled mechanisms of tissue remodeling unique to reproductive organs and cancers in adults have been discovered. The results are being applied to new medical alternatives for infertile patients and new diagnostics and therapeutics for patients with metastatic cancers. The information is also being applied to improve reproductive efficiency in animal production industries.Read moreRead less
Interactions between cells and extracellular matrix in the epithelial-mesenchymal transition of the ovarian follicular stratified epithelium. The lining of many mammalian organs and cavities contain cells that can transform into different cells to bring about organ development or repair but if it goes horribly wrong the cells become metastatic cancers. This project examines the key features of this process especially the roles of matrix that develops around the cells in this process.