Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0453630
Funder
Australian Research Council
Funding Amount
$274,692.00
Summary
High-Speed Confocal Microscope Live Cell Recording System. The high-speed confocal microscope live cell recording system we are establishing represents new generation equipment. It allows quality imaging of selected subcellular regions of live cells combined with simultaneous electrophysiological recording at rates and sensitivity hitherto not possible. This equipment provides a window of opportunity for major research advances in that it allows real-time two and three-dimensional imaging of fun ....High-Speed Confocal Microscope Live Cell Recording System. The high-speed confocal microscope live cell recording system we are establishing represents new generation equipment. It allows quality imaging of selected subcellular regions of live cells combined with simultaneous electrophysiological recording at rates and sensitivity hitherto not possible. This equipment provides a window of opportunity for major research advances in that it allows real-time two and three-dimensional imaging of fundamental cellular activities that previously could not be viewed. It will allow major advances in priority health-related research and will provide an ideal research tool to introduce young scientists and students to cutting edge research.Read moreRead less
Structure and function of heterodimeric amino acid transporters. Recently a new family of amino acid transporters has been identified, the members of which are involved in the delivery of amino acids between cells and tissues. All members display a rather unusual structure in that they require two subunits to be functional. The main aim of this study is to investigate the interaction between large and small subunits. The study will give insight how membrane proteins form complexes in the membran ....Structure and function of heterodimeric amino acid transporters. Recently a new family of amino acid transporters has been identified, the members of which are involved in the delivery of amino acids between cells and tissues. All members display a rather unusual structure in that they require two subunits to be functional. The main aim of this study is to investigate the interaction between large and small subunits. The study will give insight how membrane proteins form complexes in the membrane and how these interactions affect the function of a complex membrane protein.Read moreRead less
Identifying genes that influence clinical course and susceptibility in multiple sclerosis. This project aims to identify the genetic basis of multiple sclerosis (MS), the most common neurologic disease in young Australian adults. MS urgently needs research to identify predisposition, aid early diagnosis and provide bona fide molecular targets for new therapies. This will benefit people with MS and those susceptible to it. Crucial new knowledge identified will benefit other major areas of MS rese ....Identifying genes that influence clinical course and susceptibility in multiple sclerosis. This project aims to identify the genetic basis of multiple sclerosis (MS), the most common neurologic disease in young Australian adults. MS urgently needs research to identify predisposition, aid early diagnosis and provide bona fide molecular targets for new therapies. This will benefit people with MS and those susceptible to it. Crucial new knowledge identified will benefit other major areas of MS research including epidemiology, immunology and neurobiology. Collaboration of 8 major Australian institutions is also important for this project and future studies. The team will have access to a new national MS GeneBank (platform) with samples from 2240 patients that should generate findings important to world-wide MS genetic knowledge.Read moreRead less
Amino acids as nutrients - the molecular basis of amino acid absorption in kidney and intestine. Nutrition is a critical factor for well being and health. This is highlighted by the increase in frequency of type II diabetes and the obesity problem that all societies with a western diet face. Most studies in nutrition focus on fat and carbohydrates because of their direct involvement in obesity and diabetes. Proteins and the resulting peptides and amino acids, however, form 10-15% of our nutritio ....Amino acids as nutrients - the molecular basis of amino acid absorption in kidney and intestine. Nutrition is a critical factor for well being and health. This is highlighted by the increase in frequency of type II diabetes and the obesity problem that all societies with a western diet face. Most studies in nutrition focus on fat and carbohydrates because of their direct involvement in obesity and diabetes. Proteins and the resulting peptides and amino acids, however, form 10-15% of our nutrition. At a time where protein-rich diets are recommended to fight obesity and diabetes, it is important to understand the basis of protein absorption and metabolism. This project investigates the mechanism and mediators of amino acid absorption in kidney and intestine. Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989788
Funder
Australian Research Council
Funding Amount
$108,481.00
Summary
Nuclear Magnetic Resonance Microimaging and Relaxometry Facility. Many of the research projects to be supported by the facility are dedicated to improving our understanding of conditions and diseases that detrimentally affect many in our community. Projects investigating Alzheimer's disease, the central nervous system and its ability to repair, cancer and associated therapeutic treatments are some of the areas that will benefit from access to this equipment. The new facility will also provide un ....Nuclear Magnetic Resonance Microimaging and Relaxometry Facility. Many of the research projects to be supported by the facility are dedicated to improving our understanding of conditions and diseases that detrimentally affect many in our community. Projects investigating Alzheimer's disease, the central nervous system and its ability to repair, cancer and associated therapeutic treatments are some of the areas that will benefit from access to this equipment. The new facility will also provide unique insights into aspects of fundamental plant biology, with implications for improving crop productivity and better managing our natural ecosystems. The community will also benefit from the development and testing within the facility of new diagnostic tools and markers for a range of diseases.Read moreRead less
Special Research Initiatives - Grant ID: SR1101002
Funder
Australian Research Council
Funding Amount
$21,000,000.00
Summary
Stem Cells Australia. Despite progress in stem cell research, scientists do not understand how stem cells “decide” what to become. Stem Cells Australia will draw upon strengths within Australia’s premier stem cell research universities and institutes. This collaboration between leading bioengineering, nanotechnology, stem cell and advanced molecular analysis experts, will fast-track efforts to deliver a fundamental understanding of the mechanisms of stem cell regulation and differentiation, and ....Stem Cells Australia. Despite progress in stem cell research, scientists do not understand how stem cells “decide” what to become. Stem Cells Australia will draw upon strengths within Australia’s premier stem cell research universities and institutes. This collaboration between leading bioengineering, nanotechnology, stem cell and advanced molecular analysis experts, will fast-track efforts to deliver a fundamental understanding of the mechanisms of stem cell regulation and differentiation, and the ability to control and influence this process. Stem Cells Australia will deliver new methods for stem cell propagation and manipulation, new translational technologies for therapeutic applications, and will prepare Australia’s future stem cell scientific leaders.Read moreRead less
SCRC: PhD: Reducing The Taint In Barramundi Farmed In Recirculating Freshwater Systems
Funder
Fisheries Research and Development Corporation
Summary
Inconsistent quality of farmed barramundi (pond or recirculation system) in the marketplace has been identified by ABFA as a major issue causing buyer resistance and negative market impacts. This is limiting realisation of full revenue return for farmed barramundi. The inconsistency in quality is mainly associated with the presence of ‘earthy’ or ’muddy’ taints derived from planktonic and benthic algae (particularly cyanobacteria), fungi and actinomycetes which are known to p ....Inconsistent quality of farmed barramundi (pond or recirculation system) in the marketplace has been identified by ABFA as a major issue causing buyer resistance and negative market impacts. This is limiting realisation of full revenue return for farmed barramundi. The inconsistency in quality is mainly associated with the presence of ‘earthy’ or ’muddy’ taints derived from planktonic and benthic algae (particularly cyanobacteria), fungi and actinomycetes which are known to produce geosmin (GSM) and 2-methyl isoborneol (MIB). These compounds impart muddy, earthy, musty odour, detectable by the human palate when present at extremely low concentrations in water and fish, and not favoured by consumers (Percival et al., 2008). This project aims to develop an algae-taint production model for recirculation systems. This innovative approach will provide clear and measurable direction for reducing taint compound levels through provision of a practical management tool. Its use will significantly improve knowledge of the balance between water quality, algicide use and purging time and conditions, and taint variability.Read moreRead less
Methylation-sensitive T Cell Genes And Childhood Food Allergy.
Funder
National Health and Medical Research Council
Funding Amount
$461,232.00
Summary
Australia has the highest reported prevalence food allergy in the world. Despite this, little is known about how allergy develops. Mounting evidence implicates environmentally induced disruption of the genetic blueprint via a process known as epigenetics. We are combining the strengths of food challenge proven food allergy with assessment of immune functioning & cutting edge genomics, to extensively characterise the pathways leading to food allergy in children.
Improving neuronal cell function with cell permeable copper complexes. Metal-based drugs offer an exciting new approach to treatment of neurodegeneration. However, little is known about how cells metabolise these drugs and this information is critical for further drug development. This project will determine how metal-based drugs are metabolised by neuronal cells and how this may result in therapeutic benefit.
Enabling Land-based Production Of Juvenile Yellowtail Kingfish In NSW
Funder
Fisheries Research and Development Corporation
Funding Amount
$325,000.00
Summary
This application addresses the NSW FRAB and FRDC Subprogram Priority 2 INDUSTRY 25 – Developing Marine Finfish Aquaculture in NSW.
NSW imports approximately 85% of its seafood and needs a substantial increase in investment and production, most notably, new marine based aquaculture development is required. However, marine aquaculture development is fundamentally constrained by the lack of background biological and economic information. To develop marine finfish production, the NSW govern ....This application addresses the NSW FRAB and FRDC Subprogram Priority 2 INDUSTRY 25 – Developing Marine Finfish Aquaculture in NSW.
NSW imports approximately 85% of its seafood and needs a substantial increase in investment and production, most notably, new marine based aquaculture development is required. However, marine aquaculture development is fundamentally constrained by the lack of background biological and economic information. To develop marine finfish production, the NSW government has invested significantly in establishing a 20 ha Marine Aquaculture Research Lease (MARL) off Port Stephens with approval to produce up to 998 t fish/annum. Yellowtail Kingfish (YTK) is the primary species of interest. This interest in YTK is in part driven by a shortfall of Kingfish and Barramundi from aquaculture in local markets – of the order of 460 t at the Sydney Fish Market alone in 2013.
This project will complement the DoA project "Growing a profitable, innovative and collaborative Australian YTK aquaculture industry: bringing ‘white’ fish to the market - RnD4Profit-14-01-027". The end users are the Public, Regulators and Industry. Research will address short term needs to develop marine fish farming in eastern Australia and to provide a platform for ongoing research.
Industry need: YTK production within Australia has been challenging and further research is needed, particularly when entering new farming environments. It is essential to identify supply chains from broodstock to market. In particular, culture of the largest juveniles possible on land before transfer to seacages is essential to optimise survival and production. Land-based techniques need to be developed for viable production of advanced juvenile YTK.
Public need: Extensive public consultation identified key concerns with respect to the sustainable operation of the MARL. Keys concerns related to viable operation of marine fish farming and need to be investigated.
Regulatory need: There is a need for NSW DPI to develop a Marine Waters Sustainable Aquaculture Strategy for NSW (MWSAS) to streamline investment pathways and promote sustainable seafood production. Data from this project will be an essential component of the MWSAS. Objectives: 1. to validate the feasibility of the PSFI hatchery to produce commercial quantities of YTK fingerlings 2. to determine the feasibility and logistics of large-scale, land-based systems for production of advanced juvenile YTK Read moreRead less