Restoring Microcirculatory Perfusion In ST-elevation Myocardial Infarction: The RESTORE MI Study
Funder
National Health and Medical Research Council
Funding Amount
$3,274,537.00
Summary
Current heart attack treatments have focussed on re-opening the blocked coronary artery but despite this, many patients still suffer significant heart damage because of inadequate blood flow to the heart muscle due to damage to the small blood vessels - the microcirculation. This study seeks to identify heart attack patients with damage to the microcirculation and will conduct a randomised trial of clot busting medications to reduce microcirculation damage and to improve heart function.
Significance Of Microparticles In The Pathogenesis Of Liver Ischemia Reperfusion Injury
Funder
National Health and Medical Research Council
Funding Amount
$643,958.00
Summary
The overall aim of the project is to investigate the significance of microparticles in liver ischemia reperfusion injury (IRI). IRI causes damage to donor livers stored in preparation for liver transplantation. We postulate that microparticles released from the liver are critical in this form of injury. The expected outcomes are novel insights into liver IRI with the aim of developing new approaches to prevent liver damage during liver surgery, transplantation and shock.
Creating A Vascularized Human Liver Organoid To Treat Liver Disease
Funder
National Health and Medical Research Council
Funding Amount
$696,968.00
Summary
Due to a shortage of donor livers many patients suffering liver failure die before a liver transplant can be arranged. This project will grow human liver tissue (termed a liver organoid) using a specilaized human liver support material in which human liver cells and their specific blood vessels are assembled in the laboratory. The liver organoid will be transplanted into animals with a liver disease similar to a known human liver disease to test if the organoid can cure the liver disease.
A Targeted Approach To Age Related Disease: Nanomedicines And The Liver Sinusoidal Endothelium
Funder
National Health and Medical Research Council
Funding Amount
$560,241.00
Summary
Cells that line the liver blood vessels undergo predictable and distinct changes with age that increase the risk of developing diseases of older age like Diabetes and Cardiovascular Disease. We can now selectively target the changes in the liver cells with nanomedicines to prevent and treat these changes. The implications of this study are vast – a new therapy for the prevention and treatment of age-related cardiovascular disease and diabetes.