Type 1 Diabetes And The Metabolic Syndrome: Defining This Modern-day Phenotype, And Exploring The Effects Of Exercise On Glycaemic Control And Both Traditional And Novel Diabetes Complications
Funder
National Health and Medical Research Council
Funding Amount
$122,714.00
Summary
This research aims to define trends in the prevalence of, and complications associated with, metabolic syndrome in adults with type 1 diabetes, using the Australian National Diabetes Information Audit and Benchmarking Initiative (ANDIAB). Subsequently, a randomised controlled trial will examine the effect of exercise on glycaemic control and diabetes complications risk profiles in this group. These studies will thus address disease profiles and a potential beneficial clinical intervention.
Closed-loop Insulin Delivery Compared With Islet Cell Transplantation For Adults With Type 1 Diabetes And Impaired Awareness Of Hypoglycaemia
Funder
National Health and Medical Research Council
Funding Amount
$92,745.00
Summary
Hypoglycaemia in adults with type 1 diabetes is common. Evaluation of therapies – the ‘artificial pancreas’ and islet cell transplantation - is warranted in a cohort with repeated episodes of hypoglycaemia. This proposal will assess whether the ‘artificial pancreas’ and islet cell transplantation, compared with usual insulin therapy, will reduce hypoglycaemia and improve other clinical outcomes over 6 months. This has potential to expand therapies used in current clinical practice.
Determinants Of Glycemic Control In Australian Children With Type 1 Diabetes- A National Population Based Study.
Funder
National Health and Medical Research Council
Funding Amount
$90,524.00
Summary
The aim of the study is to examine the influence of practices and therapies used in Australian youth with Type 1 Diabetes and the clinical and demographic predictors of blood glucose control. Optimized blood glucose control reduces the risk of progression to kidney disease, vision impairment and cardiovascular disease. This study will provide insight into the influences on blood glucose control, including those that are modifiable. This will provide an evidence base to inform clinical practice.
Analysis Of Proinsulin-epitope Specific CD4+ T Cells In Blood Of People With Type 1 Diabetes
Funder
National Health and Medical Research Council
Funding Amount
$122,834.00
Summary
Type 1 diabetes (T1D) is an incurable autoimmune disease characterised by T-cell mediated destruction of insulin-secreting cells of the pancreas. Development of preventative therapies is hampered by paucity of knowledge regarding the targets of the autoimmune T-cell response. We have recently identified epitopes ‘seen’ by islet-infiltrating T-cells, located in proinsulin. Our aim is to examine proinsulin-specific T-cell responses in the peripheral blood of people with and without T1D.
Exploring Models For Antibody Mediated Endocrine Disease
Funder
National Health and Medical Research Council
Funding Amount
$140,949.00
Summary
Common endocrine disorders like Graves’ disease, are mediated by auto-antibodies, causing uncontrolled hormonal expression and undesirable effects. However, due to the limited understanding of the antibody interactions, the treatment is still focused on controlling the hormone production/interactions instead of targeting the underlying autoimmune processes. This project aims to further characterise the role the antibody through animal studies and developing novel treatments based on the research ....Common endocrine disorders like Graves’ disease, are mediated by auto-antibodies, causing uncontrolled hormonal expression and undesirable effects. However, due to the limited understanding of the antibody interactions, the treatment is still focused on controlling the hormone production/interactions instead of targeting the underlying autoimmune processes. This project aims to further characterise the role the antibody through animal studies and developing novel treatments based on the research.Read moreRead less