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A Randomised Trial Of Constraint Induced Movement Therapy And Botulinum Toxin A In Children With Congenital Hemiplegia.
Funder
National Health and Medical Research Council
Funding Amount
$399,995.00
Summary
Congenital hemiplegia occurs in over 1 million children under 21 years of age in the industrialized world. It is the most common type of cerebral palsy, accounting for 36 percent of children diagnosed with this lifelong condition. We intend to determine if a promising new treatment approach is effective in providing a superior and lasting benefit, compared to conventional techniques. Children with hemiplegia usually have the intellectual capacity to attend normal school; however the impaired arm ....Congenital hemiplegia occurs in over 1 million children under 21 years of age in the industrialized world. It is the most common type of cerebral palsy, accounting for 36 percent of children diagnosed with this lifelong condition. We intend to determine if a promising new treatment approach is effective in providing a superior and lasting benefit, compared to conventional techniques. Children with hemiplegia usually have the intellectual capacity to attend normal school; however the impaired arm reduces independence in activities of daily living and can compromise their ability to participate in educational, leisure and vocational roles. Previously we have shown that a program of upper limb rehabilitation in children with spasticity was effective in improving participation and quality of life. We have also shown that rehabilitation combined with Botulinum toxin A (Botox) can further improve functional activity. We believe that a new method of therapy, that has been used effectively in Adults with stroke, called Constraint Induced Movement Therapy (CIMT) may also be beneficial in the treatment of children with congenital hemiplegia. In CIMT, the unimpaired arm is constrained in a glove to promote use of the impaired arm (hemiplegic arm). We predict that, combined with the Botox treatment, CIMT will provide a superior and longer lasting benefit compared to standard rehabilitation combined with Botox. The primary aim of our study is to test this hypothesis in a controlled trial. A secondary aim is to further our understanding of the central neurovascular mechanisms underlying changes in upper limb function. To achieve this, we will use Functional Magnetic Resonance Imaging (fMRI) and Transcranial Magnetic Stimulation (TMS) to measure central activation in the parts of the brain controlling movement. Improving our understanding of the mechanisms involved in this condition is an essential next step towards providing a more effective and long lasting treatment.Read moreRead less
Viral Triggers Of Autoimmunity And Type 1 Diabetes: A Prospective Study Of At Risk Children
Funder
National Health and Medical Research Council
Funding Amount
$475,106.00
Summary
We are studying the role of viruses in causing type 1 (insulin dependent) diabetes. By following babies from birth, we can see whether early signs of damage to the body's insulin producing cells results from infection with particular viruses. We will study the genes and other features of these viruses to help us understand why they cause diabetes, and how they relate to other factors such as diet and vitamin D. The results may provide valuable information for the future prevention of diabetes.
Childhood Diabetes: Prediction, Prevention And Preservation Of Beta Cells
Funder
National Health and Medical Research Council
Funding Amount
$577,189.00
Summary
Childhood onset type 1 diabetes is a severe life-long disease that has a major impact on the child and their family. While studies have attempted to modify the immune system before or after diagnosis, few clinical trials have recruited young children. The overarching goal of this fellowship is to improve the lives of young people with diabetes, through a multifaceted program of ground-breaking research aimed at prediction, prevention and preservation of insulin producing ?-cells in the pancreas.
Determinants Of Glycemic Control In Australian Children With Type 1 Diabetes- A National Population Based Study.
Funder
National Health and Medical Research Council
Funding Amount
$90,524.00
Summary
The aim of the study is to examine the influence of practices and therapies used in Australian youth with Type 1 Diabetes and the clinical and demographic predictors of blood glucose control. Optimized blood glucose control reduces the risk of progression to kidney disease, vision impairment and cardiovascular disease. This study will provide insight into the influences on blood glucose control, including those that are modifiable. This will provide an evidence base to inform clinical practice.
Childhood Diabetes: Translating Evidence Into Practice
Funder
National Health and Medical Research Council
Funding Amount
$444,014.00
Summary
Type 1 diabetes is one of the most common chronic diseases of childhood. The burden of disease on the individual, their family and the community is enormous. The goal of this fellowship is to utilise evidence-based research to inform health policy and enhance the care of young people with diabetes. The proposal addresses patterns of disease in Australia, environmental triggers for diabetes, and care of the young person with diabetes through implementation of national evidence based clinical care ....Type 1 diabetes is one of the most common chronic diseases of childhood. The burden of disease on the individual, their family and the community is enormous. The goal of this fellowship is to utilise evidence-based research to inform health policy and enhance the care of young people with diabetes. The proposal addresses patterns of disease in Australia, environmental triggers for diabetes, and care of the young person with diabetes through implementation of national evidence based clinical care guidelines for type 1 diabetes.Read moreRead less