Antigen Presentation, Recognition And The Immune Response
Funder
National Health and Medical Research Council
Funding Amount
$14,927,045.00
Summary
This program focuses on understanding the development of immunity during infection or inflammatory diseases using a broad array of techniques to dissect the function of various immune cell types and to explore the relationship between structure and function of important cell surface molecules. These studies will improve our ability to design new generation vaccines for combating infectious diseases, controlling cancer, or limiting autoimmune or inflammatory diseases.
Antigen Presentation, Recognition And The Immune Response
Funder
National Health and Medical Research Council
Funding Amount
$15,780,848.00
Summary
This program focuses on understanding the development of immune response to viruses and other infectious agents using a broad array of techniques to dissect the function of various immune cell types and to explore the relationship between structure and function of important cell surface molecules. These studies will improve our ability to design new generation vaccines for combating infectious diseases, controlling cancer, or limiting autoimmune diseases like diabetes.
Unravelling The Mechanism Of MHC Class-I Associated Drug Hypersensitivities
Funder
National Health and Medical Research Council
Funding Amount
$566,308.00
Summary
Some drugs cause adverse reactions that are life threatening. We think these reactions are mediated by killer T cells as they are genetically controlled by immune response genes that normally guide immunity to microbes. We will study immune reactions to the drug abacavir, used to treat HIV (AIDS); allopurinol used to prevent gout and carbamazepine, used to treat epilepsy. The study may also help devise better treatments for patients who experience severe forms of these reactions.
Global production networks and worker representation in Myanmar. This project aims to assess the impact of global production networks on worker representation in Myanmar’s garment sector, which is leading the country’s integration into global supply chains at this crucial time in its economic and political development. This project’s findings will be used to theorise how complex interactions between different economic and social actors across geographic scale affect the rights and interests of g ....Global production networks and worker representation in Myanmar. This project aims to assess the impact of global production networks on worker representation in Myanmar’s garment sector, which is leading the country’s integration into global supply chains at this crucial time in its economic and political development. This project’s findings will be used to theorise how complex interactions between different economic and social actors across geographic scale affect the rights and interests of garment workers, and the quality of their employment. This will provide significant benefits that will make an important contribution to scholarly understandings of the impact of labour agency on global production networks and provide a strong evidence base for decision-making by local and international stakeholders.Read moreRead less
Determinant Spreading And The Role Of The MHC Class II Region In Systemic And Organ-specific Autoimmunity
Funder
National Health and Medical Research Council
Funding Amount
$140,570.00
Summary
Autoimmune diseases are among the most important group of disorders affecting the adult population. In these diseases the immune system damages organs and tissues producing widespread pathology (systemic autoimmunity such as Lupus erythematosus) or localised disease (organ-specific autoimmunity such as insulin dependent diabetes). We understand very little about how and why the immune system attacks the body's own tissues. This study examines how antibodies and T lymphocytes are formed against c ....Autoimmune diseases are among the most important group of disorders affecting the adult population. In these diseases the immune system damages organs and tissues producing widespread pathology (systemic autoimmunity such as Lupus erythematosus) or localised disease (organ-specific autoimmunity such as insulin dependent diabetes). We understand very little about how and why the immune system attacks the body's own tissues. This study examines how antibodies and T lymphocytes are formed against components located inside cells of the body. The study involves genetically modifying mice by introducing key human genes which influence the development of autoimmunity. In this way the role of these human genes can be examined experimentally without having to work exclusively on patients. We also hope that these mice might be important in creating new models of celiac disease and insulin dependent diabetes. The proposed experiments should tell us how these genes contribute to the development of autoimmune disease. This understanding could be relevant devising treatments and interventions to prevent autoimmune diseases.Read moreRead less
Protect from harm or lead into danger? The influence of peers in leisure activities on adolescent behaviour. When are peers a bad influence? This project will offer answers about the leisure settings that expose young people to risk and those that protect them from harm during the high school years. This research will also help identify those youth who may be especially vulnerable to negative effects of peer influence.
The Kids in Communities Study: national investigation of community level effects on children's developmental outcomes. This project (a cross-disciplinary collaboration) will investigate community level factors influencing early childhood developmental outcomes using a mixed methods approach in up to 10 communities across Australia. This will result in a potential set of measures or indicators that reflect communities that are good for children.
Trade unionism and trade union aid in Indonesia, Malaysia and Timor- Leste. This project will trace flows of trade union aid to Indonesia, Malaysia and Timor Leste and analyses its impact on local labour movements. It will provide valuable information about the trade unions and industrial relations systems of each country, and new insights into the international politics and practice of the international labour movement.
ARC Centre of Excellence for Children and Families over the Life Course. The 2020 ARC Centre of Excellence for Children and Families over the Life Course (LCC2020) aims to deliver transformative research and translation to break the cycle of deep and persistent disadvantage for Australians. Critically, LCC2020 will tackle disadvantage in specific context to understand how people negotiate it daily in real places, and how best to design policies and programs that support improved life pathways. B ....ARC Centre of Excellence for Children and Families over the Life Course. The 2020 ARC Centre of Excellence for Children and Families over the Life Course (LCC2020) aims to deliver transformative research and translation to break the cycle of deep and persistent disadvantage for Australians. Critically, LCC2020 will tackle disadvantage in specific context to understand how people negotiate it daily in real places, and how best to design policies and programs that support improved life pathways. By understanding life course contexts much more finely and using new methods and better data to personalise responses to disadvantage, LCC2020 will deliver the evidence, infrastructure, capacity and partnerships to reduce disadvantage and better equip Australian children and families for emerging challenges. Read moreRead less