Risk Stratification Of Older People In Hospital: Validation And Influence On Clinical Decision Making
Funder
National Health and Medical Research Council
Funding Amount
$291,067.00
Summary
Older people in hospital are at high risk of adverse outcomes, a vulnerability commonly referred to as frailty. In community-dwelling older people, frailty status can be measured precisely with a Frailty Index score. This research aims to develop a Frailty Index from a standardised comprehensive geriatric assessment instrument used in the routine care of many patients in hospital. This would assist clinicians to identify vulnerable older inpatients, improving their care in the acute setting.
Evaluation Of SCID-I In The Diagnosis Of Mental Disorders In Indigenous Australians
Funder
National Health and Medical Research Council
Funding Amount
$988,007.00
Summary
Current estimates of mental disease among Indigenous Australians are inadequate. This research will examine the use of a structured interview tool that is promoted globally for diagnosing mental disorders, and then use the tool to quantify the burden of mental illness among Indigenous Australians. The findings will provide accurate estimates of occurrence of mental disorders, thereby help inform policy making and planning of services for Indigenous Australians.
Discovery Early Career Researcher Award - Grant ID: DE120102503
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Circulating tumor cell isolation and detection: an integrated microfluidic capture device based on alternating current (AC) electrohydrodynamics. The detection of circulating tumor cells in clinical samples plays a critical role in cancer diagnosis and management. This project aims to develop microfluidic technology by incorporating AC electric field-induced vortices with three-dimensional microstructured electrodes that will advance our ability to analyse rare cells and proteins in clinical sam ....Circulating tumor cell isolation and detection: an integrated microfluidic capture device based on alternating current (AC) electrohydrodynamics. The detection of circulating tumor cells in clinical samples plays a critical role in cancer diagnosis and management. This project aims to develop microfluidic technology by incorporating AC electric field-induced vortices with three-dimensional microstructured electrodes that will advance our ability to analyse rare cells and proteins in clinical samples.Read moreRead less
Tuneable “Nano-Shearing”: An Innovative Mechanism for the Accurate and Specific Capture of Cells and Molecules. Recent investigations have discovered a tuneable electro-hydrodynamic force which drives lateral fluid motion within a few nanometers of an electrode surface. Because the magnitude of this fluid shear force can be tuned externally (for example, via the application of an AC electric field), it provides a new capability to physically displace weakly (non-specifically) bound cellular and ....Tuneable “Nano-Shearing”: An Innovative Mechanism for the Accurate and Specific Capture of Cells and Molecules. Recent investigations have discovered a tuneable electro-hydrodynamic force which drives lateral fluid motion within a few nanometers of an electrode surface. Because the magnitude of this fluid shear force can be tuned externally (for example, via the application of an AC electric field), it provides a new capability to physically displace weakly (non-specifically) bound cellular and molecular analytes. By performing research to further understand and develop this tuneable effect, this project aims to build and test a new platform technology to enable highly efficient capture and specific detection of low concentration pathogenic molecules and circulating tumour cells (CTCs).Read moreRead less
Microchip Impedance Biosensor for Biomedical Diagnostics. This research proposal uses an innovative engineering approach based on novel nanomaterials with the aim of developing a new and generic biosensing technology with the potential to be widely applied in many areas including medical diagnostics, environmental control, industry and biosecurity. The outcomes from this project will benefit Australia by contributing through the development of novel materials, new technologies and new devices. ....Microchip Impedance Biosensor for Biomedical Diagnostics. This research proposal uses an innovative engineering approach based on novel nanomaterials with the aim of developing a new and generic biosensing technology with the potential to be widely applied in many areas including medical diagnostics, environmental control, industry and biosecurity. The outcomes from this project will benefit Australia by contributing through the development of novel materials, new technologies and new devices. The development of technological innovations based on fabricated nanomaterials, will also enhance capacity in frontier technology such as nanotechnology, and build Australia’s strength in using new biosensing technologies.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC220100035
Funder
Australian Research Council
Funding Amount
$4,958,927.00
Summary
ARC Training Centre for Hyphenated Analytical Separation Technologies . The toughest analytical science challenges typically require advanced analytical technologies to acquire the desired solutions. In the field of separation science this inevitably involves hyphenated separation technologies, specifically the combination of chromatography and mass spectrometry. Advancing this technology to its full capability requires the collaborative strength of academic, industry and end-user partnerships, ....ARC Training Centre for Hyphenated Analytical Separation Technologies . The toughest analytical science challenges typically require advanced analytical technologies to acquire the desired solutions. In the field of separation science this inevitably involves hyphenated separation technologies, specifically the combination of chromatography and mass spectrometry. Advancing this technology to its full capability requires the collaborative strength of academic, industry and end-user partnerships, providing the materials and inspiration for young researchers to apply novel hyphenated methods to complex environmental and industrial systems. This Centre will deliver fundamental developments in hyphenated technologies, new analytical capability, and applied outcomes across multiple end-user groups and interests. Read moreRead less
A Mathematical Model of the Roles of Contraction and Oxygen in Human Wound Healing. Slow or impaired wound healing and excessive scarring associated with burns are both painful and costly. Moreover, the debilitating effect of chronic wounds can be expected to increase with the continuing aging of the population and the current rise in incidence of Type 2 diabetes. This project brings together a multidisciplinary team to develop a mathematical model of human wound healing and to drive the modelli ....A Mathematical Model of the Roles of Contraction and Oxygen in Human Wound Healing. Slow or impaired wound healing and excessive scarring associated with burns are both painful and costly. Moreover, the debilitating effect of chronic wounds can be expected to increase with the continuing aging of the population and the current rise in incidence of Type 2 diabetes. This project brings together a multidisciplinary team to develop a mathematical model of human wound healing and to drive the modelling to generate important breakthroughs at the level of basic science with implications for both experimentalists and clinicians.Read moreRead less
Automatic cartilage segmentation in magnetic resonance imaging. Osteoarthritis (OA) is the most common form of arthritis, affecting nearly 1.4 million Australians. This research aims at engineering new tools for use in Magnetic Resonance Imaging systems to enable automated analyses of the cartilage and bones in joint images. The goals of the work are to assist with improved diagnosis and treatment planning for both chronic disease, such as OA, and acute injuries, such as cartilage and ligament ....Automatic cartilage segmentation in magnetic resonance imaging. Osteoarthritis (OA) is the most common form of arthritis, affecting nearly 1.4 million Australians. This research aims at engineering new tools for use in Magnetic Resonance Imaging systems to enable automated analyses of the cartilage and bones in joint images. The goals of the work are to assist with improved diagnosis and treatment planning for both chronic disease, such as OA, and acute injuries, such as cartilage and ligament tears in sporting injuries and other traumas.
The software developed will be provided on the project’s partner (Siemens) platform and will therefore be available worldwide and have a consequently large impact on the field.
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Dynamic magnetic resonance imaging in orthopaedics. The research in this proposal aims at developing new imaging systems that enable joints to be imaged while they are moving. This is an Australian first technology and will change the way in which diagnosis of joint diseases is done. The applications of this new technique include the diagnosis and monitoring of treatment in Osteoarthritis and related chronic joint diseases. Also, acute injuries to knees, hips, shoulders and other joints will be ....Dynamic magnetic resonance imaging in orthopaedics. The research in this proposal aims at developing new imaging systems that enable joints to be imaged while they are moving. This is an Australian first technology and will change the way in which diagnosis of joint diseases is done. The applications of this new technique include the diagnosis and monitoring of treatment in Osteoarthritis and related chronic joint diseases. Also, acute injuries to knees, hips, shoulders and other joints will be able to be better diagnosed and hence improve treatment planning as a result.Read moreRead less
Sino-Australian neurogenetics initiative. This project will undertake large population studies to identify genes that are associated with motor neuron disease, schizophrenia and intracranial haemorrhage. The project will determine genetic markers, aid development of diagnostic tools and identify new therapeutic targets for these common heritable neurological diseases.