Understanding and controlling bioavailability: passive dosing of persistent organic pollutants into recombinant cell bioassays. Bioassays with mammalian cell lines may replace animal testing in chemical risk assessment if issues with limited sensitivity can be overcome for very hydrophobic chemicals such as polychlorinated dibenzodioxins. The project will solve this problem by developing a polymer-release dosing technique that assures defined and constant exposure.
A novel path to environmental and human health risk assessment of transformation products. Chemical pollution is a threat to our rivers and drinking water supplies. Degradation during water treatment and in the environment may lead to persistent and toxic transformation products. This project will provide a practical and cost-efficient risk assessment strategy for transformation products - to help ensure that our drinking water is safe.
Disinfection by-products formed during drinking water treatment: reducing the unknowns is managing risk. Disinfection of drinking water is a successful measure to reduce water-borne diseases and protect health. However, epidemiological evidence links bladder cancer to disinfection by-products formed during drinking water treatment. Despite decades of research the causative agents remain to be identified. To fill this knowledge gap, this project will quantify the fraction of toxicity that cannot ....Disinfection by-products formed during drinking water treatment: reducing the unknowns is managing risk. Disinfection of drinking water is a successful measure to reduce water-borne diseases and protect health. However, epidemiological evidence links bladder cancer to disinfection by-products formed during drinking water treatment. Despite decades of research the causative agents remain to be identified. To fill this knowledge gap, this project will quantify the fraction of toxicity that cannot be explained by known chemicals in water samples treated with different disinfectants using a combination of chemical analysis and in-vitro bioassays. Samples with high unexplained effects will then be fractionated to isolate toxicologically relevant disinfection by-products, which will ultimately be identified with non-target chemical analysis.Read moreRead less