Validation Of A Multiplexed Blood Based Screening Assay For The Diagnosis Of Colorectal Cancer
Funder
National Health and Medical Research Council
Funding Amount
$556,712.00
Summary
Colorectal cancer (CRC) is the second most common cancer in Australia with poor patient outcome due to late detection of the disease. We have developed a simple blood based test that can diagnose individuals with CRC at an early stage when the chance of cure is greater than 80%.
Learning Software Security Analysers with Imperfect Data. This project aims to systematically investigate next-generation learning-based software security analysis to detect vulnerabilities in real-world large-scale software. The expected learning-based foundation will support the handling of imperfect data in order to provide a precise, scalable and adaptive security analysis of the critical software components, thus capturing important security vulnerabilities missed by existing approaches. Th ....Learning Software Security Analysers with Imperfect Data. This project aims to systematically investigate next-generation learning-based software security analysis to detect vulnerabilities in real-world large-scale software. The expected learning-based foundation will support the handling of imperfect data in order to provide a precise, scalable and adaptive security analysis of the critical software components, thus capturing important security vulnerabilities missed by existing approaches. The success of this project will further enhance the international competitiveness of Australian research in this important field and will benefit any Australian industry and business where software systems are deeply-rooted, such as transportation, smart homes, medical devices, defence and finance.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC220100035
Funder
Australian Research Council
Funding Amount
$4,958,927.00
Summary
ARC Training Centre for Hyphenated Analytical Separation Technologies . The toughest analytical science challenges typically require advanced analytical technologies to acquire the desired solutions. In the field of separation science this inevitably involves hyphenated separation technologies, specifically the combination of chromatography and mass spectrometry. Advancing this technology to its full capability requires the collaborative strength of academic, industry and end-user partnerships, ....ARC Training Centre for Hyphenated Analytical Separation Technologies . The toughest analytical science challenges typically require advanced analytical technologies to acquire the desired solutions. In the field of separation science this inevitably involves hyphenated separation technologies, specifically the combination of chromatography and mass spectrometry. Advancing this technology to its full capability requires the collaborative strength of academic, industry and end-user partnerships, providing the materials and inspiration for young researchers to apply novel hyphenated methods to complex environmental and industrial systems. This Centre will deliver fundamental developments in hyphenated technologies, new analytical capability, and applied outcomes across multiple end-user groups and interests. Read moreRead less
Strategies for the detection of designer steroids in racehorses. The Australian racing industry drives economic activity and contributes $1 billion to GDP, $151 million Government revenue and 50,000 jobs in NSW. Racing depends on maintaining the highest standards of integrity. This project will make Australia a world leader by developing robust methods to detect designer steroids in thoroughbred racing.
Targeting conjugated markers with new metabolomic methods. Detecting the illicit use of natural steroids like testosterone, or compounds that modulate natural steroid levels, remains the greatest challenge for drug testing in all forms of sport. This project aims to develop new metabolomic methods based on liquid chromatography-high resolution mass spectrometry to detect the changes occurring in the conjugated steroid profile following the administration of steroids or steroid modulators. The in ....Targeting conjugated markers with new metabolomic methods. Detecting the illicit use of natural steroids like testosterone, or compounds that modulate natural steroid levels, remains the greatest challenge for drug testing in all forms of sport. This project aims to develop new metabolomic methods based on liquid chromatography-high resolution mass spectrometry to detect the changes occurring in the conjugated steroid profile following the administration of steroids or steroid modulators. The intended outcome will be a set of sensitive and analytical methods using a range of newly identified conjugated steroid markers and associated reference materials, which promises to enhance integrity and animal welfare in the thoroughbred racing industry.
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Sino-Australian neurogenetics initiative. This project will undertake large population studies to identify genes that are associated with motor neuron disease, schizophrenia and intracranial haemorrhage. The project will determine genetic markers, aid development of diagnostic tools and identify new therapeutic targets for these common heritable neurological diseases.
Novel Functional Testing For Early Diabetic Retinopathy
Funder
National Health and Medical Research Council
Funding Amount
$447,578.00
Summary
About 7.5% of Australians have diabetes and 62% of them will have signs of damage to their eyes within 6 years of diagnosis. Diabetes is 2 to 3 times more common amongst Aboriginal Australians. A group of researchers at the Australian National University are collaborating to bring a new test for the severity of diabetic eye disease to the market within 3 years. The objective is to provide doctors with a rapid, cost-effective tool to help them recognize sight-threatening damage and to assist in t ....About 7.5% of Australians have diabetes and 62% of them will have signs of damage to their eyes within 6 years of diagnosis. Diabetes is 2 to 3 times more common amongst Aboriginal Australians. A group of researchers at the Australian National University are collaborating to bring a new test for the severity of diabetic eye disease to the market within 3 years. The objective is to provide doctors with a rapid, cost-effective tool to help them recognize sight-threatening damage and to assist in treatment.Read moreRead less
Imaging the world of miniature venomous arthropods. Venomous arthropods produce a myriad of biologically active peptides, with many having potential as pharmacological tools, bioinsecticides and pharmaceuticals. Most studies to date have focussed on large arthropods; smaller species remain neglected due to the difficulties of venom collection. This project seeks to further advance the pioneering imaging mass spectrometry approaches the project team developed for imaging toxins in the venom gland ....Imaging the world of miniature venomous arthropods. Venomous arthropods produce a myriad of biologically active peptides, with many having potential as pharmacological tools, bioinsecticides and pharmaceuticals. Most studies to date have focussed on large arthropods; smaller species remain neglected due to the difficulties of venom collection. This project seeks to further advance the pioneering imaging mass spectrometry approaches the project team developed for imaging toxins in the venom glands of spiders and centipedes. By combining high-resolution matrix-assisted laser desorption ionisation imaging data with histological and transcriptomic information the project aims to provide the first detailed insights into the neglected world of miniature arthropod venoms. The approaches developed by this project aim to have wide application in the field of biology.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE150100795
Funder
Australian Research Council
Funding Amount
$365,000.00
Summary
New approaches to estimating nonlinear time-varying macroeconometric models. Quantitative models are essential for formulating good policies. In a changing world, the analysis should be based on models that allow the behaviour of the economy to change over time. Due to computational limitations, however, one is often restricted to linear models, even when nonlinear ones are more appropriate. This project aims to develop new methods for estimating time-varying nonlinear models. Two important appl ....New approaches to estimating nonlinear time-varying macroeconometric models. Quantitative models are essential for formulating good policies. In a changing world, the analysis should be based on models that allow the behaviour of the economy to change over time. Due to computational limitations, however, one is often restricted to linear models, even when nonlinear ones are more appropriate. This project aims to develop new methods for estimating time-varying nonlinear models. Two important applications are also considered: one investigates how the zero lower bound on interest rates affects the monetary policy transmission mechanism; and, the other examines how uncertainties about monetary and fiscal policy affect economic growth and inflation. This project will have strong practical significance for conducting macroeconomic policy.Read moreRead less
Measuring inflation expectations and inflation expectations uncertainty. This project aims to construct model-based measures of inflation expectations and inflation expectations uncertainty. Inflation expectations can determine economic outcomes. This project will develop non-linear time-varying models to combine information from noisy and possibly biased measures of inflation expectations from surveys and financial markets. These model-based measures are expected to be better calibrated and to ....Measuring inflation expectations and inflation expectations uncertainty. This project aims to construct model-based measures of inflation expectations and inflation expectations uncertainty. Inflation expectations can determine economic outcomes. This project will develop non-linear time-varying models to combine information from noisy and possibly biased measures of inflation expectations from surveys and financial markets. These model-based measures are expected to be better calibrated and to provide valuable information for policymakers for formulating macroeconomic policies. They can be used to better assess the credibility of monetary policy and shed light on the causes of low inflation rate in developed economies.Read moreRead less