The Molecular Basis For Manganese Uptake By Pathogenic Bacteria.
Funder
National Health and Medical Research Council
Funding Amount
$632,949.00
Summary
Bacterial antimicrobial resistance is an increasing threat to human health. At this point in time, there is an urgent, fundamental need for the development of new antimicrobial strategies. Bacterial infection involves a constant tug-of-war between the pathogen and the human host for the essential nutrients of life, including trace metal nutrients such as Mn. This project seeks to understand the machinery for Mn uptake by pathogenic bacteria as a target for novel antibacterial design.
Modulation Of Neurotherapeutic Cell Signalling Pathways By Metallo-complexes As A Treatment For Alzheimers Disease.
Funder
National Health and Medical Research Council
Funding Amount
$653,113.00
Summary
Alzheimer's disease (AD) is an enormous burden on the Australian health care system . We have begun to investigate therapeutic treatments based on triggering protective cell signalling pathways with metal-based compounds. These compounds trigger the activation of a signalling cascade resulting in inhibition of AD-associated symptoms. In this proposal we will further investigate how these compounds modulate specific receptors and cellular kinase activity to protect neurons in the AD brain.
Optimal Topological Design of 3D Continuum Structures for Crashworthiness. There is a widespread need throughout the Australian transport, defence and construction industries for high performance energy absorption devices. Data from the Australian Transport Safety Bureau show that in 2002 there were 1,715 people killed in 1,525 crashes in Australia. The proposed research will develop advanced techniques for improving crashworthiness of vehicles, roadside barriers and other energy absorption devi ....Optimal Topological Design of 3D Continuum Structures for Crashworthiness. There is a widespread need throughout the Australian transport, defence and construction industries for high performance energy absorption devices. Data from the Australian Transport Safety Bureau show that in 2002 there were 1,715 people killed in 1,525 crashes in Australia. The proposed research will develop advanced techniques for improving crashworthiness of vehicles, roadside barriers and other energy absorption devices. This will lead to significant reductions in injury to people and damage to structures caused by impact; and thus substantial savings for the nation from the enormous costs associated with the fatalities, injuries and structural damages. Read moreRead less
Development of a new rail maintenance technology by using laser cladding. With the continuously increasing demand for higher production, and hence increased haulage rates and reduced track access for maintenance purposes, the development and application of new cost effective manufacture and repair rails maintenance strategies play a more important role in ensuring the structural integrity of rail infrastructure. This project aims to systematically investigate the laser cladding materials and par ....Development of a new rail maintenance technology by using laser cladding. With the continuously increasing demand for higher production, and hence increased haulage rates and reduced track access for maintenance purposes, the development and application of new cost effective manufacture and repair rails maintenance strategies play a more important role in ensuring the structural integrity of rail infrastructure. This project aims to systematically investigate the laser cladding materials and parameters to enhance the wear and fatigue performance of a series of high strength rail steels used in heavy haul railway lines. The outcomes of this project intend to be applied directly to the rail industry track producers and operators of high axle load rail systems to develop and improve their rail maintenance strategies.Read moreRead less
Development of laser cladding technology to maintain rails in tram networks. This project aims to develop a new cost-effective maintenance technique by applying laser cladding to enhance the characteristics of new rails and track components and repair damaged ones, so as to ensure their structural integrity and improve the performance of rail infrastructure. This project expects to generate new knowledge in the area of railway maintenance using the innovative and interdisciplinary laser claddin ....Development of laser cladding technology to maintain rails in tram networks. This project aims to develop a new cost-effective maintenance technique by applying laser cladding to enhance the characteristics of new rails and track components and repair damaged ones, so as to ensure their structural integrity and improve the performance of rail infrastructure. This project expects to generate new knowledge in the area of railway maintenance using the innovative and interdisciplinary laser cladding technology. Expected outcomes of this project are crucial for manufacturers and operators of railway networks to develop and improve their railway maintenance strategies. This should provide significant benefits, such as extending lives of rails and special track components, and reducing wheel squeal and flanging noise.Read moreRead less
Modelling and control of electromagnetically propelled arcs in joining processes. Magnetically impelled arc butt (MIAB) joining is a non-traditional manufacturing process for tubular steel components. Parameter selection and tuning have to date been experimentally determined via exhaustive trial-and-error techniques. Therefore the full capabilities of the process have not yet been realised. The project aims to model and optimise the complex process and thus facilitate the development of new a ....Modelling and control of electromagnetically propelled arcs in joining processes. Magnetically impelled arc butt (MIAB) joining is a non-traditional manufacturing process for tubular steel components. Parameter selection and tuning have to date been experimentally determined via exhaustive trial-and-error techniques. Therefore the full capabilities of the process have not yet been realised. The project aims to model and optimise the complex process and thus facilitate the development of new and effective control strategies. It is expected that novel power source designs will emerge as an outcome of the research proposed.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE130100090
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Novel anodic coating of magnesium alloy components for corrosion protection. This research aims to protect magnesium alloys from corrosion, paving a path for them to be used as auto and aircraft components. It will establish novel protective anodic coatings upon magnesium and thereby pioneer implementation of magnesium alloys more generally, as galvanising did for steels.
Copper Homeostasis And APP-induced Neurodegeneration In Drosophila
Funder
National Health and Medical Research Council
Funding Amount
$381,223.00
Summary
Alzheimer s disease, a debilitating neurodegenerative disorder suffered by many of our elderly, is characterised by the presence of abnormal protein accumulations called plaques in the brains of affected patients. Plaques contain amyloid protein and also have high levels of the essential metals copper and zinc. Copper is needed for the formation of these protein aggregations and increases the toxic effects of amyloid, leading to the idea that copper-binding chemicals could be used to treat Alzhe ....Alzheimer s disease, a debilitating neurodegenerative disorder suffered by many of our elderly, is characterised by the presence of abnormal protein accumulations called plaques in the brains of affected patients. Plaques contain amyloid protein and also have high levels of the essential metals copper and zinc. Copper is needed for the formation of these protein aggregations and increases the toxic effects of amyloid, leading to the idea that copper-binding chemicals could be used to treat Alzheimer s disease. However experiments in animal models have produced conflicting results, some suggesting that increased copper levels protect against neuronal damage while others claim the opposite effect. Comparison of these studies is hampered by the different experimental systems used. We will clarify the role of copper in the progression of Alzheimer s disease using a simple insect model, the fly Drosophila melanogaster. Production of amyloid in Drosophila neuronal tissues produces a neurodegenerative effect similar to that seen in human brains, but in a matter of weeks rather than the years required in humans. We will combine production of amyloid with production of copper uptake and export proteins to investigate the effect of changing copper levels. We will also test the effect of increasing copper and other metals in the diet to see whether dietary levels are an important factor in disease progression. Finally, we will use the Drosophila model to test large numbers of metal binding compounds and drugs for ones that slow or halt the neuronal damage caused by amyloid production, identifying potential therapeutics for the treatment of Alzheimer s disease. This work will provide a vital and definitive clarification of the role of copper in the progression of Alzheimer s disease and potentially lead to the development of novel treatments for this disease that is rapidly becoming a major social and economic problem in the developed world.Read moreRead less