Target Of Rapamycin control of nutrient uptake. This project aims to study nutrient uptake in eukaryotes. It is expected to generate new knowledge of critical and conserved features of environmental and Target Of Rapamycin (TOR)-mediated control of nutrient uptake, specifically endocytosis, building on novel preliminary data that identifies novel TOR control points. The expected outcomes include new insights into mechanisms controlling nutrient uptake and fostering institutional collaboration. T ....Target Of Rapamycin control of nutrient uptake. This project aims to study nutrient uptake in eukaryotes. It is expected to generate new knowledge of critical and conserved features of environmental and Target Of Rapamycin (TOR)-mediated control of nutrient uptake, specifically endocytosis, building on novel preliminary data that identifies novel TOR control points. The expected outcomes include new insights into mechanisms controlling nutrient uptake and fostering institutional collaboration. This knowledge is highly relevant to any industry or research project utilising living organisms, as nutrient availability supports survival, cell growth and proliferation.Read moreRead less
How do cells survive nutrient stress? Insight into mechanisms. This project studies cell survival under nutrient stress in eukaryotes. Building on extensive preliminary data that identifies novel TOR (Target of Rapamycin) Complex 2 (TORC2) control points it expects to generate new knowledge of critical and conserved features of stress control of macroautophagy that ensures cell survival. It uses interdisciplinary and innovative approaches to validate and characterize nutrient-stress dependent si ....How do cells survive nutrient stress? Insight into mechanisms. This project studies cell survival under nutrient stress in eukaryotes. Building on extensive preliminary data that identifies novel TOR (Target of Rapamycin) Complex 2 (TORC2) control points it expects to generate new knowledge of critical and conserved features of stress control of macroautophagy that ensures cell survival. It uses interdisciplinary and innovative approaches to validate and characterize nutrient-stress dependent signaling. Expected outcomes include novel insights into environmental control of cell proliferation and forging cross institutional collaborations. This knowledge benefits basic and applied biology and is relevant to industries/projects utilizing living cells as nutrient supports cell survival and proliferation.Read moreRead less
Unravelling a canonical mitochondrial stress response pathway. Stress has a major impact on all life forms and is considered one of the key determinants of healthy ageing. This project aims to unravel a highly novel pathway through which many different forms of stress converge to induce a conserved stress response in mammalian cells. Major outcomes include rewriting the textbook on how stress is sensed by cells and how cells respond to this stress and will provide novel approaches and technologi ....Unravelling a canonical mitochondrial stress response pathway. Stress has a major impact on all life forms and is considered one of the key determinants of healthy ageing. This project aims to unravel a highly novel pathway through which many different forms of stress converge to induce a conserved stress response in mammalian cells. Major outcomes include rewriting the textbook on how stress is sensed by cells and how cells respond to this stress and will provide novel approaches and technologies for studying stress in a broad range of organisms and systems. This project will benefit all efforts to understand stress and aid efforts by others to ameliorate stress-mediated health defects across the animal kingdomRead moreRead less
Novel regulatory mechanisms for the protein kinase Akt. This project aims to investigate unique feedback/feedforward regulatory behaviour of the protein kinase Akt by combining novel mathematical modelling with innovative lab methods for assessing Akt function in live cells. The project aspires to generate new knowledge that advances signal transduction research and provide computational and lab tools that provide an important resource for other researchers. The project will provide significant ....Novel regulatory mechanisms for the protein kinase Akt. This project aims to investigate unique feedback/feedforward regulatory behaviour of the protein kinase Akt by combining novel mathematical modelling with innovative lab methods for assessing Akt function in live cells. The project aspires to generate new knowledge that advances signal transduction research and provide computational and lab tools that provide an important resource for other researchers. The project will provide significant benefits such as transforming efforts to design Akt therapeutics and enabling other researchers to make new discoveries.Read moreRead less
The combined use of proteomics and small molecules for target identification and pathway analysis. This project intends to investigate how a series of new small molecules identified from our research to improve the metabolic effects of insulin. This project will integrate medicinal chemistry with proteomics and metabolic biology to identify the cellular targets and their mechanism of action.