Characterization of the dark metabolome of eukaryotic cells. The project aims to investigate the full metabolic potential of a group of eukaryotic organisms using advanced analytical and computational techniques. It will identify novel metabolites and enzyme activities that are currently not predicted from genome annotations. Expected outcomes of the project include the delineation of new metabolic processes that are common to all eukaryotes, the characterization of new enzymes families, and the ....Characterization of the dark metabolome of eukaryotic cells. The project aims to investigate the full metabolic potential of a group of eukaryotic organisms using advanced analytical and computational techniques. It will identify novel metabolites and enzyme activities that are currently not predicted from genome annotations. Expected outcomes of the project include the delineation of new metabolic processes that are common to all eukaryotes, the characterization of new enzymes families, and the generation of comprehensive metabolic databases. An improved understanding of cellular metabolism will provide direct benefits in biotechnology, food production, environmental monitoring and the diagnosis and treatment of human metabolic and infectious diseases. Read moreRead less
Australian Laureate Fellowships - Grant ID: FL200100096
Funder
Australian Research Council
Funding Amount
$3,367,940.00
Summary
Mapping the genetic and lifestyle landscape of Healthy Ageing. This project aims to dissect how genes interact with the environment to control healthy ageing using a multidisciplinary approach combining state-of-the-art omics technologies, metabolic and ageing phenotyping and genetic analysis and a highly diverse model system. The project is expected to establish fundamental new understanding of the ageing process by identifying genes that regulate ageing either alone or in response to diet; by ....Mapping the genetic and lifestyle landscape of Healthy Ageing. This project aims to dissect how genes interact with the environment to control healthy ageing using a multidisciplinary approach combining state-of-the-art omics technologies, metabolic and ageing phenotyping and genetic analysis and a highly diverse model system. The project is expected to establish fundamental new understanding of the ageing process by identifying genes that regulate ageing either alone or in response to diet; by defining the mechanism by which such genes control ageing and by identifying biomarkers that predict different ageing outcomes. This knowledge will contribute to future strategies based on genetic testing and biomarkers to optimise healthy ageing in humans. Read moreRead less