A Randomised Controlled Trial Of Interventional Versus Conservative Treatment Of Primary Spontaneous Pneumothorax
Funder
National Health and Medical Research Council
Funding Amount
$412,315.00
Summary
Primary spontaneous pneumothorax (PSP) is a collapsed lung that occurs in otherwise healthy people without underlying lung disease. Current standard treatment is to insert a chest drain into the chest to remove the air around the collapsed lung so that the lung re-inflates rapidly ("interventional treatment"). We will determine whether doing nothing, i.e. letting the lung re-inflate slowly on its own over several weeks ("conservative treatment"), is just as good or even better for patients.
Re-EValuating The Inhibition Of Stress Erosions (REVISE): Gastrointestinal Bleeding Prophylaxis In ICU
Funder
National Health and Medical Research Council
Funding Amount
$2,955,164.00
Summary
Around 50,000 patients in Australian Intensive Care Units receive a drug called pantoprazole each year with the aim of preventing bleeding from the gut. Recent research suggests this practice is ineffective and may harm patients by increasing their risk of serious infections. We will perform a definitive study to determine whether the widespread use of pantoprazole is beneficial or harmful.
Long term economic impacts of disease on older workers to 2030: Costs to government and individuals and opportunities for intervention. This project will fill substantial gaps in Australian evidence about the health conditions of the future that will keep older workers out of the labour market and diminish their own immediate and long-term livings standards, thereby reducing funds available to government. We will address one of the most significant issues resulting from the fundamental changes t ....Long term economic impacts of disease on older workers to 2030: Costs to government and individuals and opportunities for intervention. This project will fill substantial gaps in Australian evidence about the health conditions of the future that will keep older workers out of the labour market and diminish their own immediate and long-term livings standards, thereby reducing funds available to government. We will address one of the most significant issues resulting from the fundamental changes to the demography of the Australian labour market and one that is regularly raised by the government following the release of the 2002 and 2007 Intergenerational Reports. This project will also examine the interventions that would improve the health of older workers and increase labour force participation over the long term.Read moreRead less
Can parents teach their children to drink alcohol responsibly? Or, is one drop a drop too many? Parents typically supply alcohol to their children believing it is the best way to teach responsible drinking. Whether parents should provide alcohol is controversial and the evidence to inform this decision is unclear. This research will provide an in-depth understanding of the consequences of parents providing alcohol to their children and when, where and how this can be done to minimise harm. This ....Can parents teach their children to drink alcohol responsibly? Or, is one drop a drop too many? Parents typically supply alcohol to their children believing it is the best way to teach responsible drinking. Whether parents should provide alcohol is controversial and the evidence to inform this decision is unclear. This research will provide an in-depth understanding of the consequences of parents providing alcohol to their children and when, where and how this can be done to minimise harm. This is a national priority as alcohol abuse is a leading cause of injury and death among young Australians and developing the knowledge for preventive health care is essential. This research will provide parents with the information they need to give their children a healthier start to life.Read moreRead less
Endocrine signalling from bone cells in the regulation of glucose and energy homeostasis. Osteoporosis, obesity and diabetes are increasingly common, all of which are in urgent need of more effective therapies. This project examines powerful neuropeptide signalling pathways that integrate bone homeostasis with whole body energy and glucose balance. Initial studies have defined the efferent hypothalamic pathways of this system and this project will build upon these findings to examine the feedbac ....Endocrine signalling from bone cells in the regulation of glucose and energy homeostasis. Osteoporosis, obesity and diabetes are increasingly common, all of which are in urgent need of more effective therapies. This project examines powerful neuropeptide signalling pathways that integrate bone homeostasis with whole body energy and glucose balance. Initial studies have defined the efferent hypothalamic pathways of this system and this project will build upon these findings to examine the feedback signals produced by bone cells to regulate adipose and pancreatic function. Exploring this entirely new paradigm of skeletal biology, will reveal novel circulating factors capable of regulating adipose and glucose economies, as well as bone mass, thereby offering potential therapies for these debilitating conditions.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE120102878
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Mobile phone text reminders to modify behaviours and prevent cardiovascular disease. Strategies are needed to improve adherence to behavioural and medical preventative treatments for heart disease. Brief informative reminders sent via mobile phone text message have potential as a cheap and safe method of improving behavioural change and adherence to treatments in people at risk of cardiovascular disease.
Can and should we link data at a national level? Vaccine safety surveillance: A case study. This project provides many benefits for the community, exploring the legal and ethical issues around consent for data linkage, convening Citizens' Juries to weigh the evidence and make recommendations. It addresses National Research Priorities: Promoting and Maintaining Good Health and Safeguarding Australia as well as National Collaborative Research Infrastructure Strategy priorities. It uses vaccine sa ....Can and should we link data at a national level? Vaccine safety surveillance: A case study. This project provides many benefits for the community, exploring the legal and ethical issues around consent for data linkage, convening Citizens' Juries to weigh the evidence and make recommendations. It addresses National Research Priorities: Promoting and Maintaining Good Health and Safeguarding Australia as well as National Collaborative Research Infrastructure Strategy priorities. It uses vaccine safety surveillance as a case study to evaluate the effectiveness of data linkage (through linking Commonwealth immunisation data to state hospital data) and the methodologies and lessons learnt from cross jurisdictional data linkage can be transferred to other areas. Read moreRead less
Multi-dimensional Temporal Abstraction to Support Neonatal Clinical Research. Each year, the death of a baby causes grief for thousands of Australian parents, contributes to depression and considerable anxiety in the population. In this work we propose procedures that will significantly reduce this unhappy scenario. The availability of a complex trend and pattern analysis will give Neonatologists access to predictive clinical analysis that has not previously been available locally or internation ....Multi-dimensional Temporal Abstraction to Support Neonatal Clinical Research. Each year, the death of a baby causes grief for thousands of Australian parents, contributes to depression and considerable anxiety in the population. In this work we propose procedures that will significantly reduce this unhappy scenario. The availability of a complex trend and pattern analysis will give Neonatologists access to predictive clinical analysis that has not previously been available locally or internationally. Thus, significant benefits in terms of lower mortality rates and lower long-term disability rates among babies requiring special care is possible. This research will provide the basis for future projects that will support regional hospitals.Read moreRead less
Planning female and male vaccination and cervical screening strategies to achieve optimal prevention of HPV-related disease. The findings from this research will inform the development of public health policy on the most cost-effective utilisation of resources for preventing cervical, anogenital and head/neck cancers, and genital warts, in women and men, due to human papillomavirus (HPV). We will evaluate strategies for using emerging screening and vaccine technologies to prevent HPV-related dis ....Planning female and male vaccination and cervical screening strategies to achieve optimal prevention of HPV-related disease. The findings from this research will inform the development of public health policy on the most cost-effective utilisation of resources for preventing cervical, anogenital and head/neck cancers, and genital warts, in women and men, due to human papillomavirus (HPV). We will evaluate strategies for using emerging screening and vaccine technologies to prevent HPV-related disease, and assess potential adverse outcomes of vaccination. Men are currently not covered by routine vaccination or screening programs; this research will assess the benefit to men of vaccinating women only, and will consider the impact of vaccination and other interventions targeted towards men.Read moreRead less
Life-saving chemo/radio-therapy commonly renders women and girls who survivor cancer infertile or sterile. We have discovered a new means of preserving the fertility of female mice exposed to chemo/radio therapy. In this project we will apply these advances to human ovarian tissue/eggs for the first time. We have access to these rare tissues for research purposes. This project will develop new approaches to fertility preservation for cancer survivors.