Mechanosensitive properties and modulation of N-methyl-D-aspartate (NMDA) receptors by lipid environment. This project will provide new information about the molecular determinants which influence NMDA receptor channel gating that will significantly advance our understanding of a link between NMDA receptor function and many neurodegenerative diseases as well as pain and learning and memory. The outcomes of this project may lead to the discovery of novel lipid-based biomaterials for application i ....Mechanosensitive properties and modulation of N-methyl-D-aspartate (NMDA) receptors by lipid environment. This project will provide new information about the molecular determinants which influence NMDA receptor channel gating that will significantly advance our understanding of a link between NMDA receptor function and many neurodegenerative diseases as well as pain and learning and memory. The outcomes of this project may lead to the discovery of novel lipid-based biomaterials for application in medicine and the drug industry. This research is highly significant in relation to human health. The biological and nutritional aspects of polyunsaturated lipids and dietary fish oils have long been recognized. Thus this project will provide further knowledge that could benefit the health of the nation with consequent reduced health care costs.Read moreRead less
Fundamentality. Australia is a world leader in metaphysical research. This project aims to strengthen the tradition of Australian metaphysics, by studying fundamentality, or the notion of being fundamental. It revives the classical monistic worldview on which we are interdependent and interrelated fragments of a greater whole. It thus connects the philosophical tradition of Plotinus, Spinoza, and Hegel to the physical picture of the cosmos as a single entangled quantum system, and so promises to ....Fundamentality. Australia is a world leader in metaphysical research. This project aims to strengthen the tradition of Australian metaphysics, by studying fundamentality, or the notion of being fundamental. It revives the classical monistic worldview on which we are interdependent and interrelated fragments of a greater whole. It thus connects the philosophical tradition of Plotinus, Spinoza, and Hegel to the physical picture of the cosmos as a single entangled quantum system, and so promises to deepen our understanding of our place in nature—while strengthening Australian leadership in the field.Read moreRead less
Evolvability and the Evolution of Complexity. Anyone engaging in a moment's reflection on the striking richness, diversity, and complexity of the biological world is faced with the question: how did it get here? Though natural selection is central to answering this question, important new work has identified various conditions that make some lineages of organisms "evolvable": capable of changing in ways that radically expand the range of further possible changes. This project will clarify and in ....Evolvability and the Evolution of Complexity. Anyone engaging in a moment's reflection on the striking richness, diversity, and complexity of the biological world is faced with the question: how did it get here? Though natural selection is central to answering this question, important new work has identified various conditions that make some lineages of organisms "evolvable": capable of changing in ways that radically expand the range of further possible changes. This project will clarify and integrate these various conditions using empirical examples and simple models. The resulting work from this project will provide a clearer general understanding of what biological complexity is, and how science has compelling candidates for understanding how it evolves.Read moreRead less
John Locke, botany and natural kinds. This project will enhance the status of research into early modern science and philosophy in Australia. It is a project of major significance in Locke studies and in the history of botany and it will impinge on a number of current philosophical debates to which Australians are already making a major contribution: the nature of biological species; natural kinds; and scientific method. Those who work on early modern thought in Australia will also benefit from ....John Locke, botany and natural kinds. This project will enhance the status of research into early modern science and philosophy in Australia. It is a project of major significance in Locke studies and in the history of botany and it will impinge on a number of current philosophical debates to which Australians are already making a major contribution: the nature of biological species; natural kinds; and scientific method. Those who work on early modern thought in Australia will also benefit from the close relationship that will be established between the University of Sydney and Oxford University. The publications issuing from the project will be of international significance.Read moreRead less
Effect of modification of structural and cellular properties of the arterial wall on functional stiffness of large arteries. The Australian population is ageing, becoming more obese and showing earlier onset of age-related conditions such as high blood pressure, heart failure and inflammatory disorders. All these conditions are associated with possible increase arterial stiffness. Inflammatory disorders in Australia affect one in six people, increasing to one in five in the next decade. An equa ....Effect of modification of structural and cellular properties of the arterial wall on functional stiffness of large arteries. The Australian population is ageing, becoming more obese and showing earlier onset of age-related conditions such as high blood pressure, heart failure and inflammatory disorders. All these conditions are associated with possible increase arterial stiffness. Inflammatory disorders in Australia affect one in six people, increasing to one in five in the next decade. An equal proportion is affected by cardiovascular disease. This combined effect poses a massive burden on the national health budget. This project aims to investigate basic mechanism leading to degeneration of function of larger arteries and therapies to reverse the process and reduce cardiovascular risk in the community.Read moreRead less
The Genie in the Bottle:Science, Politics and Diplomacy in Australia's Engagement with Chemical and Biological Weapons, 1915-1995. The threat of chemical and biological weapons (CBW) is attracting increasing attention worldwide. Australia's engagement with the CBW began during the First World War. Since then, Australia has been influential in promoting CBW control regimes. However, this experience has raised many questions. This project explores Australia's historical and current response to ....The Genie in the Bottle:Science, Politics and Diplomacy in Australia's Engagement with Chemical and Biological Weapons, 1915-1995. The threat of chemical and biological weapons (CBW) is attracting increasing attention worldwide. Australia's engagement with the CBW began during the First World War. Since then, Australia has been influential in promoting CBW control regimes. However, this experience has raised many questions. This project explores Australia's historical and current response to the central issues of CBW. Using archival and contemporary sources, it analyses the interplay between science, politics and diplomacy. Combining history and political science, it assesses the implications of recent developments in CBW for Australia's role in preventing the proliferation of weapons of mass destruction.Read moreRead less