Molecular Epidemiology Of Cancers Of The Pancreas And Skin.
Funder
National Health and Medical Research Council
Funding Amount
$387,489.00
Summary
Pancreatic cancer is the 4th most common cause of cancer death in Australia. The causes of this disease are largely unknown. I am conducting research designed to understand genetic and environmental causes of pancreatic cancer. Skin cancer occurs more frequently than any other cancer in Australia. Sunlight is the most common cause but it is also possible that human papilloma viruses may play a role. If high risk types of this virus can be identified, new preventive strategies may be developed.
WHY YOUNG PEOPLE DEVELOP OLD KNEES: PREDICTORS OF EARLY JOINT CHANGES FOLLOWING KNEE LIGAMENT RECONSTRUCTION
Funder
National Health and Medical Research Council
Funding Amount
$415,218.00
Summary
My research investigates how muscles & movement patterns (i.e. biomechanics) contribute to early adverse knee cartilage & bone changes in young individuals at risk of developing premature knee osteoarthritis (OA): a debilitating disease causing pain & diminished quality of life. Biomechanical measures selected can be modified with interventions such as exercise & gait retraining. Ultimately, my research could reduce future risk of knee OA & its resultant personal & societal costs.
Alcohol-related harm is a major contributor to the total burden of disease and social problems experienced both globally and in Australia. Considerable burden is placed on health and policing sectors and at substantial financial cost. This project will significantly improve Australian capacity to monitor alcohol related harms at local, state and national levels, enhance the underlying epidemiology and understanding of relations between alcohol and harm and enable reliable and timely evaluation o ....Alcohol-related harm is a major contributor to the total burden of disease and social problems experienced both globally and in Australia. Considerable burden is placed on health and policing sectors and at substantial financial cost. This project will significantly improve Australian capacity to monitor alcohol related harms at local, state and national levels, enhance the underlying epidemiology and understanding of relations between alcohol and harm and enable reliable and timely evaluation of alcohol policy.Read moreRead less
Improving Ubiquitous Interventions To Optimise Outcomes From Critical Illness
Funder
National Health and Medical Research Council
Funding Amount
$333,710.00
Summary
A/Prof Deane is a specialist intensive care physician who combines clinical work at The Royal Melbourne Hospital with a large research program. The research supported by this Fellowship will translate to fundamental changes in the administration of ubiquitous interventions and will optimise management of conditions that occur frequently in the critically ill and represent a major source of mortality, morbidity and healthcare utilisation/costs.
Ineffective antibiotic therapy is associated with increased mortality in infected patients in the intensive care unit (ICU). Early administration of efficacious antibiotic therapy improves survival substantially. This work seeks to extend upon my previous studies that have described the different concentrations of antibiotics between ICU patients and non-ICU patients. Predicting when to change antibiotic doses in ICU patients is likely to substantially improve patient outcomes.
Refining Methods For Obtaining, Synthesising And Interpreting Research Evidence In Surgery
Funder
National Health and Medical Research Council
Funding Amount
$314,312.00
Summary
Research evidence plays a crucial role in improving clinical care. However the main forms of evidence and the tools that facilitate evidence use - namely randomised controlled trials (RCT) and structured systematic reviews of existing research - have had limited application in surgery for a variety of reasons. This project aims to promote the use of research evidence in surgical decision making by developing tools tailored to the predominance of non-RCTs in surgery and surgeons' information need ....Research evidence plays a crucial role in improving clinical care. However the main forms of evidence and the tools that facilitate evidence use - namely randomised controlled trials (RCT) and structured systematic reviews of existing research - have had limited application in surgery for a variety of reasons. This project aims to promote the use of research evidence in surgical decision making by developing tools tailored to the predominance of non-RCTs in surgery and surgeons' information needs.Read moreRead less