Novel green scalable chemical peptide synthesis and enzyme immobilization. The Project aims to address the critical issue of developing green processes for the chemical production of peptides including on an industrial scale. It will use unique, biocompatible solid supports that have been invented by our partner SpheriTech Ltd together with other reagents to allow synthesis to be conducted in water rather than toxic organic solvents. Expected outcomes of the Project include an international part ....Novel green scalable chemical peptide synthesis and enzyme immobilization. The Project aims to address the critical issue of developing green processes for the chemical production of peptides including on an industrial scale. It will use unique, biocompatible solid supports that have been invented by our partner SpheriTech Ltd together with other reagents to allow synthesis to be conducted in water rather than toxic organic solvents. Expected outcomes of the Project include an international partnership in highly efficient environmentally-friendly assembly of peptides and of their analogues by both solid phase synthesis and immobilized enzyme-mediated ligation. The clear benefit will be the first novel, water-based, scalable green synthesis of peptides as biological probes and potential therapeutic agents.Read moreRead less
New polymers for imaging applications. Cancer and cardiovascular disease are the most devastating diseases in any developed country. This project describes improved imaging agents to improve the detection and earlier treatment of diseases whilst avoiding any problems with toxicity of imaging agents in the body.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100109
Funder
Australian Research Council
Funding Amount
$530,000.00
Summary
Small molecule X-ray molecular structure elucidation facility. X-ray diffraction plays a key role in identification and molecular characterisation. X-ray techniques are the single most widely used analytical resource in structure determination and provide invaluable information for scientists working in the fields of synthesis, nanotechnology, polymer chemistry, and protein chemistry, amongst many others. The facility brings together a multidisciplinary team of scientists and provides state-of-t ....Small molecule X-ray molecular structure elucidation facility. X-ray diffraction plays a key role in identification and molecular characterisation. X-ray techniques are the single most widely used analytical resource in structure determination and provide invaluable information for scientists working in the fields of synthesis, nanotechnology, polymer chemistry, and protein chemistry, amongst many others. The facility brings together a multidisciplinary team of scientists and provides state-of-the-art research and training facilities for these techniques.Read moreRead less
Janus particles and nanorattles: new materials for paint technology. This project will pave the way for self cleaning paints that achieve opacity with greatly reduced titanium dioxide levels. Painted surfaces will maintain their clean and new look for longer and a clean town look will be much more readily maintained. More efficient use of titanium dioxide will reduce the need for sand mining and reduce the cost of quality paint.
Polymer micro-capsules for stain-resistant paint. This project aims to create an advanced micro-capsule system to be used in the manufacturing of high-performance waterborne paints on a large scale. Surface coatings seal, strengthen, and decorate the majority of surfaces in the building industry. Despite their importance, advances in paint science have only been incremental and a truly stain-resistant, robust and environmentally friendly coating has yet to be developed. This project will use pol ....Polymer micro-capsules for stain-resistant paint. This project aims to create an advanced micro-capsule system to be used in the manufacturing of high-performance waterborne paints on a large scale. Surface coatings seal, strengthen, and decorate the majority of surfaces in the building industry. Despite their importance, advances in paint science have only been incremental and a truly stain-resistant, robust and environmentally friendly coating has yet to be developed. This project will use polymer Janus nanoparticles to radically redesign architectural coatings, with the goal to reduce the use of non-renewable components, and increase stain-resistance and durability. This new technology will lead to less disruption for the environment, and important economic and technological benefits for Australia.Read moreRead less
Key Functional Additives in Paint Technology. The goal of this project is to create two novel advanced particle systems with complex architecture that can be manufactured on a large scale, which aim to lead to high-performance waterborne paints. It is intended that these paints will have three functional characteristics: provide more efficient use of titanium dioxide; display pronounced water-resistance; and contribute to removing the need for organic solvents from the gloss paint sector. This r ....Key Functional Additives in Paint Technology. The goal of this project is to create two novel advanced particle systems with complex architecture that can be manufactured on a large scale, which aim to lead to high-performance waterborne paints. It is intended that these paints will have three functional characteristics: provide more efficient use of titanium dioxide; display pronounced water-resistance; and contribute to removing the need for organic solvents from the gloss paint sector. This research aims to provide the means to create paint films with greatly improved properties at reduced cost, with reduced requirement for non-renewable resources and reduced environmental footprint.Read moreRead less
Functionalised nanomaterials for application as multimodal cancer imaging agents. Nanomaterials offer exciting opportunities for emerging diagnostic applications targeted to specific diseases. In this project, cutting-edge fundamental scientific developments will be pursued that will advance the application of nanomaterials in the diagnosis of cancer, a disease that accounts for over 40,000 deaths in Australia annually.
Polymer nanofibres for advanced paint formulations. Surface coatings seal, strengthen, and decorate the majority of surfaces in the building industry—a $72 billion market. Despite their importance, advances in paint science have only been incremental and a truly robust and water resistant paint coating has yet to be developed. Dulux Group Australia and the University of Sydney will use polymer nanofibres as additives to radically redesign architectural coatings, with the goal to drastically incr ....Polymer nanofibres for advanced paint formulations. Surface coatings seal, strengthen, and decorate the majority of surfaces in the building industry—a $72 billion market. Despite their importance, advances in paint science have only been incremental and a truly robust and water resistant paint coating has yet to be developed. Dulux Group Australia and the University of Sydney will use polymer nanofibres as additives to radically redesign architectural coatings, with the goal to drastically increase their durability. The partnership will bring a technological breakthrough that will lead to less disruption for the environment, and important economic and technological benefits for Australia.Read moreRead less
Advanced framework materials for hydrogen storage applications. This project aims to develop new molecular materials capable of the highly efficient storage of hydrogen gas. Through an innovative interdisciplinary approach that targets the synthesis and detailed characterisation of two classes of molecular material this project expects to generate step-change advances in the understanding of how hydrogen gas uptake relates to the chemical and physical attributes of porous molecular systems. Sign ....Advanced framework materials for hydrogen storage applications. This project aims to develop new molecular materials capable of the highly efficient storage of hydrogen gas. Through an innovative interdisciplinary approach that targets the synthesis and detailed characterisation of two classes of molecular material this project expects to generate step-change advances in the understanding of how hydrogen gas uptake relates to the chemical and physical attributes of porous molecular systems. Significant anticipated outcomes and benefits include the development of new material design approaches that optimise performance across a diverse parameter space, and the generation of advanced new materials worthy of commercial development, spanning small scale mobile to large scale stationary storage applications.Read moreRead less
Metal-organic Framework (MOF) Superstructure Catalysts. The development of new catalyst technology is crucial to uncovering energy-efficient strategies for valorising chemicals. Although the designable pore networks of Metal-organic Frameworks (MOFs) provide a highly favourable environment for heterogeneous catalysis, most stable MOF materials are microporous - possessing pores less than 2 nm - which hinders mass transport. This research will develop novel, hierarchically porous MOF superstruct ....Metal-organic Framework (MOF) Superstructure Catalysts. The development of new catalyst technology is crucial to uncovering energy-efficient strategies for valorising chemicals. Although the designable pore networks of Metal-organic Frameworks (MOFs) provide a highly favourable environment for heterogeneous catalysis, most stable MOF materials are microporous - possessing pores less than 2 nm - which hinders mass transport. This research will develop novel, hierarchically porous MOF superstructures that will overcome these limitations and serve as platform materials for the development of new catalysts. This research will address future challenges in industrial catalysis and realise an important step towards the commercial application of MOF catalysis for valoriation of chemical feedstocks. Read moreRead less