Topography Optimisation of Implants for Enhancing Osseointegration. With recent increased life expectancy, the ratio of implant recipients to total population has dramatically increased. The project will address a critical issue in ensuring long-term success of prosthetic treatment. The proposed computational multiscale modelling will provide a sound scientific alternative means to optimisation of overall implant design including surface topography. The anticipated outcomes of this research will ....Topography Optimisation of Implants for Enhancing Osseointegration. With recent increased life expectancy, the ratio of implant recipients to total population has dramatically increased. The project will address a critical issue in ensuring long-term success of prosthetic treatment. The proposed computational multiscale modelling will provide a sound scientific alternative means to optimisation of overall implant design including surface topography. The anticipated outcomes of this research will help improve the quality of prosthetic therapy, and benefit our prosthodontic and orthopaedic professionals and their patients. The study clearly aligns with the national research goals of frontier technologies and maintaining good health.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE180100175
Funder
Australian Research Council
Funding Amount
$347,070.00
Summary
Three-dimensional additive bio-fabrication facility: printing bioprinters. This project aims to develop bioprinting systems that will provide new insights into fundamental biological processes. The 3D Additive Bio-Fabrication Facility - Printing Bioprinters capability will use 3D polymer and metal additive manufacturing technologies to create the next generation of bioprinting methodologies and 3D fabrication tools. It is the aim that these customised additive manufacturing systems will be used ....Three-dimensional additive bio-fabrication facility: printing bioprinters. This project aims to develop bioprinting systems that will provide new insights into fundamental biological processes. The 3D Additive Bio-Fabrication Facility - Printing Bioprinters capability will use 3D polymer and metal additive manufacturing technologies to create the next generation of bioprinting methodologies and 3D fabrication tools. It is the aim that these customised additive manufacturing systems will be used to produce structures wherein living cells are spatially organised in combination with appropriate biomaterials and bioactive components, such as drugs or growth factors, in order to influence subsequent biological behaviour.Read moreRead less
Connecting man to machine: Wireless brain-machine interface. This project aims to enable direct wireless transmission of brain signals leading to reliable thought control of computers, wheelchairs, exoskeletons and vehicles. Such technology is currently limited by the fidelity, reliability, safety and longevity of the electrodes used to record signals from the brain. Partner organisation, SmartStent, has developed a novel stent-based electrode array which allows the extraction of high fidelity n ....Connecting man to machine: Wireless brain-machine interface. This project aims to enable direct wireless transmission of brain signals leading to reliable thought control of computers, wheelchairs, exoskeletons and vehicles. Such technology is currently limited by the fidelity, reliability, safety and longevity of the electrodes used to record signals from the brain. Partner organisation, SmartStent, has developed a novel stent-based electrode array which allows the extraction of high fidelity neural information without risky brain surgery and implant rejection. The project aims to combine SmartStent's stent-electrode technology with the diamond materials technology developed by the research team for hermetic encapsulation of electronics.Read moreRead less
Harnessing the bioactivity of proteins and polypeptides: understanding and controlling adsorption processes to optimise linker free immobilisation. This project will use physical techniques and simulations to understand the interactions of biomolecules and plasma activated surfaces, allowing control of the biomolecule layer composition, orientation and conformation. This control, together with the ability of these surfaces to "lock-in" the optimised layer, will create a new generation of biodevi ....Harnessing the bioactivity of proteins and polypeptides: understanding and controlling adsorption processes to optimise linker free immobilisation. This project will use physical techniques and simulations to understand the interactions of biomolecules and plasma activated surfaces, allowing control of the biomolecule layer composition, orientation and conformation. This control, together with the ability of these surfaces to "lock-in" the optimised layer, will create a new generation of biodevices.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC160100026
Funder
Australian Research Council
Funding Amount
$3,722,989.00
Summary
ARC Training Centre in Additive Biomanufacturing. ARC Training Centre in Additive Biomanufacturing. The training centre aims to bring together leading researchers and industry to develop and translate key technology platforms for personalised treatments of challenging medical conditions. The centre expects its research will lead to synergistic and innovative technologies needed for personalised therapies including: modular additive biomanufacturing platforms; advanced bio-inks for regenerative m ....ARC Training Centre in Additive Biomanufacturing. ARC Training Centre in Additive Biomanufacturing. The training centre aims to bring together leading researchers and industry to develop and translate key technology platforms for personalised treatments of challenging medical conditions. The centre expects its research will lead to synergistic and innovative technologies needed for personalised therapies including: modular additive biomanufacturing platforms; advanced bio-inks for regenerative medicine; and additive manufactured tools for surgical planning and education. Highly experienced researchers and industry partners with teams of exceptional post-doctoral fellows and doctoral students would drive each technology. Anticipated impacts are that Australia will be a world-leader in additive biomanufacturing, and that the research will change the fields of science, health and biotechnology.Read moreRead less
Soft carbon nanotube materials. There is no doubt that the realisation of new bionic materials will dramatically improve quality of life for many individuals. The new soft conducting materials proposed will impact on several areas of bionics, including the development of the next generation Bionic Ear, conduits for spinal cord regeneration as well as muscle regeneration and other applications. This project will further enhance the international profile of the ARC Centre of Excellence for Electro ....Soft carbon nanotube materials. There is no doubt that the realisation of new bionic materials will dramatically improve quality of life for many individuals. The new soft conducting materials proposed will impact on several areas of bionics, including the development of the next generation Bionic Ear, conduits for spinal cord regeneration as well as muscle regeneration and other applications. This project will further enhance the international profile of the ARC Centre of Excellence for Electromaterials Science in the field of Bionics. The end-user network already in place will ensure all opportunities are fully exploited.Read moreRead less
Conformal Bionics - addressing the challenges in bringing miniaturised implants to the site of therapeutic delivery. Smaller, more sophisticated, lifetime-implantable bionic devices capable of being placed at the site of therapeutic delivery will facilitate new or improved opportunities for treatment of disease. Three critical areas of research aim to be explored in pursuit of this goal will be addressed within this study: introduction of new fabrication materials that enable devices to conform ....Conformal Bionics - addressing the challenges in bringing miniaturised implants to the site of therapeutic delivery. Smaller, more sophisticated, lifetime-implantable bionic devices capable of being placed at the site of therapeutic delivery will facilitate new or improved opportunities for treatment of disease. Three critical areas of research aim to be explored in pursuit of this goal will be addressed within this study: introduction of new fabrication materials that enable devices to conform to the anatomy of the targeted site of therapeutic delivery; improved means of addressing the data and energy transfer needs of devices implanted in confined spaces; and innovation of novel sensors for testing and monitoring of atmospheric conditions within the implant to anticipate and safely manage issues relating to a breach of hermetic encapsulation barriers.Read moreRead less
Nanobionics. There is no doubt that the realization of new bionic materials capable of functioning at the cellular through to the mechanical level will dramatically improve quality of life for many individuals. For example, the studies proposed here will impact directly on endothelial and muscle cell growth (important for implants such as stents) and nerve cell regeneration (important for peripheral nerve cell and spinal chord repair). The establishment of the research team proposed within the f ....Nanobionics. There is no doubt that the realization of new bionic materials capable of functioning at the cellular through to the mechanical level will dramatically improve quality of life for many individuals. For example, the studies proposed here will impact directly on endothelial and muscle cell growth (important for implants such as stents) and nerve cell regeneration (important for peripheral nerve cell and spinal chord repair). The establishment of the research team proposed within the framework of the ARC Centre of Excellence in Electromaterials Science builds on world class expertise and infrastructure. The end user network in place will ensure all opportunities are exploited to the full extent.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE170100068
Funder
Australian Research Council
Funding Amount
$390,000.00
Summary
Bioinspired liposome-based smart sensors. This project aims to develop a liposome-based biosensor technology that mimics cell sensory systems. Selective detection of compounds is increasingly important for food, health and environmental monitoring. Biosensor development faces long-standing challenges such as response time, sensitivity, specificity, and multiplexing. On the other hand, cells can sense and discriminate multiple biomolecules in seconds with high sensitivity and specificity. This pr ....Bioinspired liposome-based smart sensors. This project aims to develop a liposome-based biosensor technology that mimics cell sensory systems. Selective detection of compounds is increasingly important for food, health and environmental monitoring. Biosensor development faces long-standing challenges such as response time, sensitivity, specificity, and multiplexing. On the other hand, cells can sense and discriminate multiple biomolecules in seconds with high sensitivity and specificity. This project aims to harness cells’ exquisite biological properties to improve current detection techniques. It will integrate liposome-based sensors with microfluidics to perform analytical tasks ranging from food safety to diagnostics.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC170100022
Funder
Australian Research Council
Funding Amount
$4,420,408.00
Summary
ARC Training Centre for Innovative BioEngineering. The ARC Training Centre for Musculoskeletal Biomedical Technologies will provide the next-generation of skilled graduates to overcome industry-focused challenges in musculoskeletal regeneration. The Centre expects to engineer a set of integrated technologies to personalise implants for the unique biological, physical and lifestyle characteristics of the recipient. Expected outcomes of the Centre include embedded bioelectronic sensors to assess a ....ARC Training Centre for Innovative BioEngineering. The ARC Training Centre for Musculoskeletal Biomedical Technologies will provide the next-generation of skilled graduates to overcome industry-focused challenges in musculoskeletal regeneration. The Centre expects to engineer a set of integrated technologies to personalise implants for the unique biological, physical and lifestyle characteristics of the recipient. Expected outcomes of the Centre include embedded bioelectronic sensors to assess and optimise the healing process. In addition, the Centre will produce data for use in deriving the next-generation of implants, giving rise to improved health outcomes, economic benefits, and a skilled workforce able to advance and perpetuate this important field.Read moreRead less