Protein Structural-Dynamics at Solid Surfaces: Beyond Static Snapshots. The project will use High-Speed Atomic Force Microscopy to directly visualize single proteins in ‘action’ with surfaces, revealing their dynamics at unprecedented combined structural and temporal resolution in liquid. Such characterization moves beyond static ‘snapshots’ of protein structure, toward the dynamic changes in protein conformation that will enable new exploration of key biological processes at liquid-solid interf ....Protein Structural-Dynamics at Solid Surfaces: Beyond Static Snapshots. The project will use High-Speed Atomic Force Microscopy to directly visualize single proteins in ‘action’ with surfaces, revealing their dynamics at unprecedented combined structural and temporal resolution in liquid. Such characterization moves beyond static ‘snapshots’ of protein structure, toward the dynamic changes in protein conformation that will enable new exploration of key biological processes at liquid-solid interfaces. New fundamental discoveries will have an impact on technologies such as medical device coatings, biomaterials, biosensors, microfluidics devices, protein purification and diagnostics assays that are critically dependent on the biological function of adsorbed or immobilized proteins.Read moreRead less
Harnessing the bioactivity of proteins and polypeptides: understanding and controlling adsorption processes to optimise linker free immobilisation. This project will use physical techniques and simulations to understand the interactions of biomolecules and plasma activated surfaces, allowing control of the biomolecule layer composition, orientation and conformation. This control, together with the ability of these surfaces to "lock-in" the optimised layer, will create a new generation of biodevi ....Harnessing the bioactivity of proteins and polypeptides: understanding and controlling adsorption processes to optimise linker free immobilisation. This project will use physical techniques and simulations to understand the interactions of biomolecules and plasma activated surfaces, allowing control of the biomolecule layer composition, orientation and conformation. This control, together with the ability of these surfaces to "lock-in" the optimised layer, will create a new generation of biodevices.Read moreRead less
Trapping and Watching Biomolecular Complexes near Nanopores. This project aims to develop a technology to trap and interrogate nanosized molecular complexes in their natural state. Nanosized complexes in water provide the core machinery of biological systems and require detailed understanding to help unravel fundamental biological mechanisms. A prototype of a methodology has been developed to trap and interrogate nanoscaled objects as small as 190 nanometres within a nanopore device. By performi ....Trapping and Watching Biomolecular Complexes near Nanopores. This project aims to develop a technology to trap and interrogate nanosized molecular complexes in their natural state. Nanosized complexes in water provide the core machinery of biological systems and require detailed understanding to help unravel fundamental biological mechanisms. A prototype of a methodology has been developed to trap and interrogate nanoscaled objects as small as 190 nanometres within a nanopore device. By performing research to fully understand, miniaturise and develop this method further, this project aims to enable the quantitative observation of nanoscaled biological machinery involved in cell-to-cell communication and DNA unfolding. Such a technology platform may have applications in areas such as biology, biotechnology and advanced materials.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE180100736
Funder
Australian Research Council
Funding Amount
$362,446.00
Summary
High performing multifunctional silicon nanomaterials for bio-applications. This project aims to develop high-performance, multifunctional silicon nanomaterials, and to understand their physicochemical properties for bio-imaging. A range of high-quality multifunctional silicon-based bio-probes with novel fluorescent and magnetic properties will be developed for enhancing bio-imaging. The outcomes of the project will further strengthen Australia’s leading position in the targeted areas of Advance ....High performing multifunctional silicon nanomaterials for bio-applications. This project aims to develop high-performance, multifunctional silicon nanomaterials, and to understand their physicochemical properties for bio-imaging. A range of high-quality multifunctional silicon-based bio-probes with novel fluorescent and magnetic properties will be developed for enhancing bio-imaging. The outcomes of the project will further strengthen Australia’s leading position in the targeted areas of Advanced Materials and Nanotechnology.Read moreRead less
Heat conduction characterisation of buried insulation layers in silicon-on-insulator systems. This project aims to establish a new technique for the accurate characterisation of thermal conduction in buried insulation layers in advanced silicon-on-insulator (SOI) systems. The success of the project will enable the Australian semiconductor industry to develop high performance SOI systems.
Super-resolution imaging techniques based on van der Waals materials. This project aims to address the most pressing challenges in the field of super-resolution fluorescence nanoscopies, which underpin a vast range of biomedical imaging and sensing applications. The project will develop fluorescent probes and new imaging schemes that are simultaneously ultra-bright, photostable, biocompatible and do not require the use of high-power lasers that damage samples during image acquisition. This will ....Super-resolution imaging techniques based on van der Waals materials. This project aims to address the most pressing challenges in the field of super-resolution fluorescence nanoscopies, which underpin a vast range of biomedical imaging and sensing applications. The project will develop fluorescent probes and new imaging schemes that are simultaneously ultra-bright, photostable, biocompatible and do not require the use of high-power lasers that damage samples during image acquisition. This will be achieved by exploiting unique properties of recently-discovered quantum emitters in van der Waals nanomaterials. The project outcomes will yield a new approach to super-resolution imaging, advance understanding of quantum emitters, and develop new techniques for the processing of van der Waals materials. This is expected to have applications in a diverse range of sectors, and enable new markets in nanotechnology and manufacturing of high-performance Australian-made products.Read moreRead less
Using extreme conditions to synthesise new materials. This project aims to synthesise useful materials from non-crystalline light element precursors. Boron, carbon and nitrogen are the hardest known solids, and their ability to form many kinds of chemical bonds offers opportunities for attractive new materials. This project will apply high pressures and temperatures to non-crystalline precursor materials to access previously unobtainable synthesis conditions. This project will create strong and ....Using extreme conditions to synthesise new materials. This project aims to synthesise useful materials from non-crystalline light element precursors. Boron, carbon and nitrogen are the hardest known solids, and their ability to form many kinds of chemical bonds offers opportunities for attractive new materials. This project will apply high pressures and temperatures to non-crystalline precursor materials to access previously unobtainable synthesis conditions. This project will create strong and hard materials with tuneable optical and electronic properties. The expected outcome is new light materials that emit and detect light in the far ultraviolet for biological imaging and tough materials with low friction needed for motors and regenerative technologies.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE200100032
Funder
Australian Research Council
Funding Amount
$600,000.00
Summary
Advanced Multifunctional Electro-Opto-Magneto-Mechanical Analysis Platform. This project aims to build an advanced multi-functional Electro-Opto-Magneto-Mechanical analysis platform for characterizing nanomaterials and micro-/nano-scale devices. This platform expects to provide rich and unique characterization capabilities (electrical, optical, magnetic and mechanical) for hybrid devices with low temperature and high vacuum environment. The expected outcomes include multidisciplinary research co ....Advanced Multifunctional Electro-Opto-Magneto-Mechanical Analysis Platform. This project aims to build an advanced multi-functional Electro-Opto-Magneto-Mechanical analysis platform for characterizing nanomaterials and micro-/nano-scale devices. This platform expects to provide rich and unique characterization capabilities (electrical, optical, magnetic and mechanical) for hybrid devices with low temperature and high vacuum environment. The expected outcomes include multidisciplinary research collaborations and a wide range of next-generation technologies including non-invasive medical instruments, wearable devices, communication, quantum information systems and energy storage solutions. This should enable local design and construction of hybrid devices and advance the growth of local high-technology industries.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE180100030
Funder
Australian Research Council
Funding Amount
$541,705.00
Summary
National facility for nanoscale characterisation of luminescent materials. The project aims to establish a national facility for nanoscale characterisation of advanced optoelectronic materials, including atomically-thin materials, luminescent nanocrystals, metamaterials, and plasmonic nanostructures. The combination of a highly focused electron beam, and novel light detection optics, will enable temperature-dependent, angle, polarisation and time-resolved luminescence analysis with unprecedented ....National facility for nanoscale characterisation of luminescent materials. The project aims to establish a national facility for nanoscale characterisation of advanced optoelectronic materials, including atomically-thin materials, luminescent nanocrystals, metamaterials, and plasmonic nanostructures. The combination of a highly focused electron beam, and novel light detection optics, will enable temperature-dependent, angle, polarisation and time-resolved luminescence analysis with unprecedented resolution. It is expected this will yield discoveries in nanoscale physics and materials science. It will create interdisciplinary collaborations by linking Australian scientists who use high-resolution multimodal characterisation methods to innovate and develop materials and device technologies.Read moreRead less
Dislocation motion and anelastic recovery in layered ceramic titanate. This project aims to research deformation and facture in brittle ceramic nanowire materials and anelastic behaviour in tensile deformation. Layered sodium titanate is used in energy storage and water treatment, but in-situ tensile tests have observed unconventional deformation behaviour, with significant dislocation motion and anelastic recovery. This project will study the deformation mechanism in layered sodium titanate nan ....Dislocation motion and anelastic recovery in layered ceramic titanate. This project aims to research deformation and facture in brittle ceramic nanowire materials and anelastic behaviour in tensile deformation. Layered sodium titanate is used in energy storage and water treatment, but in-situ tensile tests have observed unconventional deformation behaviour, with significant dislocation motion and anelastic recovery. This project will study the deformation mechanism in layered sodium titanate nanowires through molecular dynamics simulations, empirical interatomic potential, and in situ TEM experiments. Expected outcomes include knowledge of the deformation mechanism of this layered titanate which can be broadened to technologically important layered ceramic materials.Read moreRead less