An Investigation of Novel Sialylmimetics as Inhibitors of Rotavirus. Rotavirus causes severe gastroenteritis in infants worldwide. Over 125 million cases of diarrhoea and 800,000 deaths annually are attributed to rotavirus. The process that enables this debilitating and sometimes fatal disease to infect cells is poorly understood. This project aims to produce a range of unique chemical entities that will provide information about the way rotavirus infects cells. The chemical compounds produc ....An Investigation of Novel Sialylmimetics as Inhibitors of Rotavirus. Rotavirus causes severe gastroenteritis in infants worldwide. Over 125 million cases of diarrhoea and 800,000 deaths annually are attributed to rotavirus. The process that enables this debilitating and sometimes fatal disease to infect cells is poorly understood. This project aims to produce a range of unique chemical entities that will provide information about the way rotavirus infects cells. The chemical compounds produced in this study will be evaluated for their ability to prevent rotavirus from infecting cells. It is expected that this project will provide compounds that may ultimately be used as drugs for the treatment of rotavirus.Read moreRead less
An Investigation of Novel Sialylmimetics as Inhibitors of Rotavirus. Rotavirus causes severe gastroenteritis in infants worldwide. Over 125 million cases of diarrhoea and 800,000 deaths annually are attributed to rotavirus, primarily in developing countries. The process that enables this debilitating and sometimes fatal disease to infect cells is poorly understood. This project aims to produce a range of unique chemical entities that will provide information about the way rotavirus infects cel ....An Investigation of Novel Sialylmimetics as Inhibitors of Rotavirus. Rotavirus causes severe gastroenteritis in infants worldwide. Over 125 million cases of diarrhoea and 800,000 deaths annually are attributed to rotavirus, primarily in developing countries. The process that enables this debilitating and sometimes fatal disease to infect cells is poorly understood. This project aims to produce a range of unique chemical entities that will provide information about the way rotavirus infects cells. The chemical compounds produced will be assayed for their ability to prevent rotavirus from infecting cells. It is expected that this project will provide compounds that may ultimately be used as drugs for the treatment of rotavirus.Read moreRead less
Structure-based discovery of anti-rotaviral agents. Rotavirus causes, particularly in children under 5 years of age, significant loss of life worldwide. Over 600,000 children under 5 years of age per annum die as a result of rotavirus infection. Australia records over 10,000 hospitalisations per annum due to rotavirus infection. This project aims, using structure-based drug design techniques, to develop inhibitors of a rotavirus protein that is essential in its lifecycle. These inhibitors may ....Structure-based discovery of anti-rotaviral agents. Rotavirus causes, particularly in children under 5 years of age, significant loss of life worldwide. Over 600,000 children under 5 years of age per annum die as a result of rotavirus infection. Australia records over 10,000 hospitalisations per annum due to rotavirus infection. This project aims, using structure-based drug design techniques, to develop inhibitors of a rotavirus protein that is essential in its lifecycle. These inhibitors may lead to the development of useful drugs to treat rotavirus infection and may reduce significant loss of life caused by this deadly virus.Read moreRead less
Structure-based discovery of anti-parainfluenza viral agents. Respiratory diseases, for example croup and bronchitis, in children are caused in the main by human parainfluenza viruses (hPIVs) types 1-3. No vaccines or specific antiviral therapy against hPIV infections exist. This project targets an essential protein in the virus' lifecycle. The essential triple role of the protein in virus spread makes it an attractive target for the development of hPIV-specific drugs. This project aims to prod ....Structure-based discovery of anti-parainfluenza viral agents. Respiratory diseases, for example croup and bronchitis, in children are caused in the main by human parainfluenza viruses (hPIVs) types 1-3. No vaccines or specific antiviral therapy against hPIV infections exist. This project targets an essential protein in the virus' lifecycle. The essential triple role of the protein in virus spread makes it an attractive target for the development of hPIV-specific drugs. This project aims to produce lead-like compounds that inhibit the protein's function and may provide novel drug candidates for further development. Furthermore the role of human host cell-associated carbohydrates in parainfluenza infection will be better understood.Read moreRead less
Design, Synthesis and Biological Evaluation of Rotavirus Inhibitors. Rotavirus causes, particularly in children under 5 years of age, significant loss of life worldwide. Over 400,000 children under 5 years of age per annum die as a result of rotavirus infection. Australia records over 10,000 hospitalisations per annum due to rotavirus infection. This project aims, using structure-based drug design techniques, to develop inhibitors of a rotavirus protein that is essential in its lifecycle. The ....Design, Synthesis and Biological Evaluation of Rotavirus Inhibitors. Rotavirus causes, particularly in children under 5 years of age, significant loss of life worldwide. Over 400,000 children under 5 years of age per annum die as a result of rotavirus infection. Australia records over 10,000 hospitalisations per annum due to rotavirus infection. This project aims, using structure-based drug design techniques, to develop inhibitors of a rotavirus protein that is essential in its lifecycle. These inhibitors may lead to the development of useful drugs to treat rotavirus infection and may reduce significant loss of life caused by this deadly virus.Read moreRead less
Investigation of novel sialic acid mimetics to target the spread of cancer. The mortality rates for many cancers afflicting the world's population are extremely high and these rates are consistent with the Australian experience. It is generally accepted that colon cancer, and cancers as a whole, are a significant healthcare issue and have immense socioeconomic impact. Alternative treatments preventing the spread of cancers would be of very significant benefit. This fellowship will provide the ....Investigation of novel sialic acid mimetics to target the spread of cancer. The mortality rates for many cancers afflicting the world's population are extremely high and these rates are consistent with the Australian experience. It is generally accepted that colon cancer, and cancers as a whole, are a significant healthcare issue and have immense socioeconomic impact. Alternative treatments preventing the spread of cancers would be of very significant benefit. This fellowship will provide the opportunity for the discovery and development of such treatments that are based on the processes that utilise carbohydrates to facilitate the spread of tumours.Read moreRead less
A kinetic measuring system for assistive devices used in paediatric gait. Each year, a proportion of children are born who suffer from disabilities, which limits their ability to walk efficiently. Gait analysis can identify limiting factors in walking ability, and can assess the clinical outcome of treatments. Children who use assistive devices, such as walking frames, are denied the full benefits of gait analysis due to limitations in current equipment. This project addresses this need through ....A kinetic measuring system for assistive devices used in paediatric gait. Each year, a proportion of children are born who suffer from disabilities, which limits their ability to walk efficiently. Gait analysis can identify limiting factors in walking ability, and can assess the clinical outcome of treatments. Children who use assistive devices, such as walking frames, are denied the full benefits of gait analysis due to limitations in current equipment. This project addresses this need through the development of a portable, load-measuring instrument. When integrated with existing equipment, a comprehensive description of assisted walking gait will be possible. This will lead to greater understanding and improved treatment outcomes for such children.Read moreRead less
Resistance to pediculicides in head lice, Pediculus humanus var. capitis. The number of children with head lice in countries like Australia is increasing. One factor that promotes lice is resistance to pesticides. Yet until now resistance has not been studied in Australia. We propose a new approach to studying resistance: "field" tests by school nurses and other health workers. Existing tests require lice to be sent alive to labs in cities. Our test will, if successful, allow people in the ....Resistance to pediculicides in head lice, Pediculus humanus var. capitis. The number of children with head lice in countries like Australia is increasing. One factor that promotes lice is resistance to pesticides. Yet until now resistance has not been studied in Australia. We propose a new approach to studying resistance: "field" tests by school nurses and other health workers. Existing tests require lice to be sent alive to labs in cities. Our test will, if successful, allow people in the "field" to test lice. Expected outcomes are: (i) scientific information on resistance to pediculicides in head lice, and thus, improved control of head lice; (ii) reduced exposure of children to pesticides; and (iii) a strategic alliance between six organisations that should outlive the project.Read moreRead less
Sources, fate and exposure pathways for emerging persistent organic pollutants in Australia. Brominated flame retardants and perfluorinated chemicals have received much attention from media and environmental groups. They accumulate in biota and humans and levels are shown to be increasing. It is proposed they be included in the global treaty on persistent organic pollutants (POPs), recently ratified by Australia. This project aims to determine sources, fate and exposure pathways for these che ....Sources, fate and exposure pathways for emerging persistent organic pollutants in Australia. Brominated flame retardants and perfluorinated chemicals have received much attention from media and environmental groups. They accumulate in biota and humans and levels are shown to be increasing. It is proposed they be included in the global treaty on persistent organic pollutants (POPs), recently ratified by Australia. This project aims to determine sources, fate and exposure pathways for these chemicals with an emphasis on exposure to infants. This will provide information for risk assessment development and more effective management of these chemicals. Furthermore, the study's approach and results will contribute to a rationalization of the issues related to emerging POPs. Read moreRead less