Challenging current dogma on the inheritance of mitochondrial DNA. Mutations in mitochondrial DNA are often used to infer genetic relationships and have been associated with the expression of human diseases. This project examines the exact mechanism of inheritance of mitochondrial genes to enhance biological interpretations and our understanding of the heritability of specific diseases.
Impact of the male germ line on the mutational load carried by mammalian embryos. This project examines whether a man's age or exposure to lifestyle factors (alcohol, cigarette smoke and mobile phone radiation) can have a major effect on the health of his children. The project is particularly relevant to the safety of assisted conception procedures used to treat the 1 in 20 Australian men suffering from infertility.
Characterisation of tumour variants of Devil Facial Tumour Disease. This project will take a new approach to cancer research by studying the evolution of Devil Facial Tumour Disease. The results will directly contribute to the conservation management of the Tasmanian devil, as well as generating new information on tumour growth, metastasis and emergence of resistance.
Beyond the genome: unravelling the intricacies of epigenetic regulation using the honey bee model. Epigenetic mechanisms, such as DNA methylation, provide the interface between genome and environment. Abnormalities in epigenetic regulation lead to cancer and other diseases. The project will be using the alternative phenotypes in honeybees, fertile queens and sterile workers, to understand how dietary factors control conditional gene expression by methylation
Evolution and function of mammalian sex chromosomes. Research on iconic Australian mammals has profoundly reshaped our understanding of reproductive biology and sex chromosome evolution. In this project we combine unique expertise, international collaboration and novel genetic information about Australia's unique egg-laying mammals (echidna and platypus) to investigate major aspects of reproduction. This work will address fundamental aspects of sex chromosome biology and advance our understandin ....Evolution and function of mammalian sex chromosomes. Research on iconic Australian mammals has profoundly reshaped our understanding of reproductive biology and sex chromosome evolution. In this project we combine unique expertise, international collaboration and novel genetic information about Australia's unique egg-laying mammals (echidna and platypus) to investigate major aspects of reproduction. This work will address fundamental aspects of sex chromosome biology and advance our understanding of mammalian reproduction. The knowledge gained will have application in captive breeding and conservation of these extraordinary Australian mammals. The project also provides opportunity to train research students in cutting edge molecular biology and informatics.Read moreRead less
The regulation of gene expression by post-translational modification of transcription factors. Different cells in the body express different subsets of our genes, and it is not well understood how cells know which genes to switch on and which to switch off in a given situation. We will investigate the way in which chemical tags are put onto and removed from the molecules that control gene expression in order to direct their function.
Understanding the mechanisms that regulate the human signal recognition particle cycle. The precise cellular localisation of proteins is a fundamental process in cell biology required for survival. The aim of this project is to understand the mechanisms by which the human signal recognition particle delivers newly translated proteins to their cognate cellular location.
How males alter their mates' ageing rates and lifespans. The proposed project investigates how males affect the lifespan, ageing and subsequent reproduction of their mates. It seeks to draw on and adapt tools and approaches used in molecular genetics and physiology to test predictions from evolutionary theories of sexual conflict, life-histories and ageing in an organism of biomedical and ecological significance, the house mouse. It is expected that this approach will allow the study, in unsurpa ....How males alter their mates' ageing rates and lifespans. The proposed project investigates how males affect the lifespan, ageing and subsequent reproduction of their mates. It seeks to draw on and adapt tools and approaches used in molecular genetics and physiology to test predictions from evolutionary theories of sexual conflict, life-histories and ageing in an organism of biomedical and ecological significance, the house mouse. It is expected that this approach will allow the study, in unsurpassed detail, of the costs males impose on females via mating, insemination, territoriality and via conflict over how many offspring to have and how to invest in their care.Read moreRead less
Unified platform for real time QA in radiation therapy in brachytherapy based on high resolution silicon detectors (Magic Plate). This project will design and manufacture new devices for measuring the amount of radiation given to the patient during radiotherapy. This will improve the accuracy and safety of cancer treatment as well as greatly reducing the time needed to perform essential safety checks.
Novel imaging technologies for continuous measurement of tracer kinetics in awake animals. The fates of biologically relevant molecules, such as proteins and antibodies, in the body are fundamentally important for understanding the mechanisms and treatment of disease. This project will enable for the first time continuous imaging of the location and time course of labelled molecules in conscious, freely moving animals.