New drugs for malaria that target histone deacetylases. There is no vaccine for malaria and current drugs are failing, contributing to millions of malaria-related deaths each year. The aim of this project is to develop new drugs to address this significant global health issue. This project will focus on drugs that act in novel ways to existing malaria drugs by targeting enzymes that are involved in altering gene expression in the parasite. These kinds of enzymes are recognised drug targets in ot ....New drugs for malaria that target histone deacetylases. There is no vaccine for malaria and current drugs are failing, contributing to millions of malaria-related deaths each year. The aim of this project is to develop new drugs to address this significant global health issue. This project will focus on drugs that act in novel ways to existing malaria drugs by targeting enzymes that are involved in altering gene expression in the parasite. These kinds of enzymes are recognised drug targets in other diseases such as cancer. The outcomes of this project will include advances in malaria drug development that build on Australian drug discovery efforts, seeding further funding opportunities from industry and other sources and contributing research training and capacity building in Australia.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC180100024
Funder
Australian Research Council
Funding Amount
$4,000,000.00
Summary
ARC Training Centre for Medical Implant Technologies. The ARC Training Centre for Medical Implant Technologies aims to train a new generation of interdisciplinary engineers and to transform the orthopaedic and maxillofacial implant industry in Australia. In collaboration with industry, universities and hospitals, the Centre will build a dynamic training environment for interdisciplinary engineers to develop and evaluate personalised implants and surgeries. It will create new networks, internatio ....ARC Training Centre for Medical Implant Technologies. The ARC Training Centre for Medical Implant Technologies aims to train a new generation of interdisciplinary engineers and to transform the orthopaedic and maxillofacial implant industry in Australia. In collaboration with industry, universities and hospitals, the Centre will build a dynamic training environment for interdisciplinary engineers to develop and evaluate personalised implants and surgeries. It will create new networks, international collaborations and a generation of industry-ready researchers critical for growing Australia’s industry. The advances in materials and savings in time for procedures will reduce costs.
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The role of subject-matter knowledge in teaching science and mathematics: Practices of teachers with advanced qualifications in the sciences. High quality science and mathematics education is central to economic prosperity. This study will achieve two outcomes. Firstly it explores the importance of subject matter knowledge in teaching. Much has been studied about the knowledge of teachers but limited research has been conducted with teachers who have substantial subject-matter knowledge. These f ....The role of subject-matter knowledge in teaching science and mathematics: Practices of teachers with advanced qualifications in the sciences. High quality science and mathematics education is central to economic prosperity. This study will achieve two outcomes. Firstly it explores the importance of subject matter knowledge in teaching. Much has been studied about the knowledge of teachers but limited research has been conducted with teachers who have substantial subject-matter knowledge. These findings will inform the current debate about the appropriate models of teacher education and the balance of emphasis on content knowledge and pedagogical knowledge. Secondly, given a number of attempts to attract mid career professionals with high qualifications to teaching, the study will provide evidence on how these people transition to their new careers and what support is needed.Read moreRead less
Comparative effectiveness of three literacy teaching approaches for young children with reading difficulties. This project addresses concerns expressed by the Minister for Education, Science and Training, and the Australian Senate in regard to the relative poor performance of Australian children in national reading tests. Specifically, the project seeks to identify the most effective early literacy instructional method or methods to redress the growing concern that Australian children are droppi ....Comparative effectiveness of three literacy teaching approaches for young children with reading difficulties. This project addresses concerns expressed by the Minister for Education, Science and Training, and the Australian Senate in regard to the relative poor performance of Australian children in national reading tests. Specifically, the project seeks to identify the most effective early literacy instructional method or methods to redress the growing concern that Australian children are dropping behind in international competitiveness in reading and literacy achievement. The study concentrates on early reading development and to inform on teacher education and classroom teaching practices. Read moreRead less
Researching Collective Argumentation in Mathematics and Science Classrooms. The project will provide evidence-based pedagogical strategies for the reform of classroom teaching and learning in the crucial areas of mathematics and science. We will develop a form of pedagogy (Collective Argumentation) that enables students to be confident in deploying mathematical and scientific knowledge and skills in relation to the economic and social choices that they make in everyday contexts. Collective Argum ....Researching Collective Argumentation in Mathematics and Science Classrooms. The project will provide evidence-based pedagogical strategies for the reform of classroom teaching and learning in the crucial areas of mathematics and science. We will develop a form of pedagogy (Collective Argumentation) that enables students to be confident in deploying mathematical and scientific knowledge and skills in relation to the economic and social choices that they make in everyday contexts. Collective Argumentation can induct students into 'habits of mind and social practices' necessary for building an innovative learning community. This project will enable us to extend this innovative approach and to further develop its effectiveness.Read moreRead less
Telling Tales from the Bush: Gender, rurality and post-school transitions. The completion of formal schooling is a critical point of decision-making for all young Australians, but it is particularly critical for young men and women from the bush, who are often already disadvantaged in the quality of schooling they receive, and their access to facilities and opportunities. This longitudinal study will address a significant research gap in this area, by analysing the potentially limiting effect g ....Telling Tales from the Bush: Gender, rurality and post-school transitions. The completion of formal schooling is a critical point of decision-making for all young Australians, but it is particularly critical for young men and women from the bush, who are often already disadvantaged in the quality of schooling they receive, and their access to facilities and opportunities. This longitudinal study will address a significant research gap in this area, by analysing the potentially limiting effect gender constructs can play in the decision-making and life trajectories of these young adults. By so doing, the study contributes directly to the national interest by improving the social and economic futures of rural Australians.Read moreRead less
Emotional Transitions: Exploring Professional Transitions of Science Teachers. Research most needed to inform policy and practice for improving teacher education and the retention of new-science teachers is that which captures the experiences and development of the new teacher, particularly in the critical transition period from university to full-time work in schools. This period is fundamental to becoming a satisfied and effective teacher. Our study contributes significantly to national concer ....Emotional Transitions: Exploring Professional Transitions of Science Teachers. Research most needed to inform policy and practice for improving teacher education and the retention of new-science teachers is that which captures the experiences and development of the new teacher, particularly in the critical transition period from university to full-time work in schools. This period is fundamental to becoming a satisfied and effective teacher. Our study contributes significantly to national concerns for quality-teacher education by providing new insights into the emotions and identities of transitioning-science teachers in practice. The proposed study also models innovative procedures that can enrich subsequent longitudinal studies of teacher transitions and impact of teacher-education programs.Read moreRead less
Crisis in chemistry: How do we best teach particle concepts for understanding? Fundamental chemistry knowledge is essential in the information age because citizens and professionals need to make informed decisions about GM technology, pollution and how to teach science. Chemistry learning is compromised by recurring intuitive and taught misconceptions about atoms and molecules. The widely documented misconceptions emphasise what students cannot do. This unique project studies students, teachers ....Crisis in chemistry: How do we best teach particle concepts for understanding? Fundamental chemistry knowledge is essential in the information age because citizens and professionals need to make informed decisions about GM technology, pollution and how to teach science. Chemistry learning is compromised by recurring intuitive and taught misconceptions about atoms and molecules. The widely documented misconceptions emphasise what students cannot do. This unique project studies students, teachers and international chemistry educators to develop a theoretical and practical model of what students can understand and do in primary, secondary and university chemistry with respect to atoms and molecules. The research will significantly improve chemistry teaching at the macroscopic, microscopic and symbolic levels.Read moreRead less
How bacteria cause disease in the urinary tract. This project will investigate the virulence properties of uropathogenic Escherichia coli, the major causative agent of urinary tract infections (UTI) in humans. The results will help to understand how these bacterial pathogens cause disease and will impact strategies aimed at the prevention and treatment of chronic and recurrent UTI.
Promoting Mathematical Development through Model-Eliciting Case Studies. Rapid changes in the way mathematics is being used in the workplace means that workers now require diverse profiles of mathematical and scientific abililites, the development of which has to begin in the school years. Building on our existing democratic access to powerful mathematics that will enable all students to develop the conceptual tools needed for success beyond school. Working with teachers and graduate students, ....Promoting Mathematical Development through Model-Eliciting Case Studies. Rapid changes in the way mathematics is being used in the workplace means that workers now require diverse profiles of mathematical and scientific abililites, the development of which has to begin in the school years. Building on our existing democratic access to powerful mathematics that will enable all students to develop the conceptual tools needed for success beyond school. Working with teachers and graduate students, we will implement semester-long sequences of model-eliciting activities (authentic case studies) that will develop students' higher-order mathematical understandings and abilities, especially those whose outstanding abilities in complex real-world situations often go undetected in the classroom.Read moreRead less