Devices that use Ion Channels. The proposed device would supply the community of researchers in Australia and internationally with new techniques to enable them to quickly and conveniently investigate properties of ion channels and to speed the screening of potential ion channel targets for pharmaceutical hits and leads. In addition, the tethered membrane technology will be developed to fill an unmet need for a quick and biologically relevant test of EMC hazards. This will enhance the science an ....Devices that use Ion Channels. The proposed device would supply the community of researchers in Australia and internationally with new techniques to enable them to quickly and conveniently investigate properties of ion channels and to speed the screening of potential ion channel targets for pharmaceutical hits and leads. In addition, the tethered membrane technology will be developed to fill an unmet need for a quick and biologically relevant test of EMC hazards. This will enhance the science and technology infrastructure within Australia, taking it into original and exciting directions, contribute to training young Australian scientists and students, as well as enhance Australia's competitive position in the field of nanobiotechnology.Read moreRead less
Synthesis of new heterocyclic analogues of isoflavones. Intake of high dietary isoflavonoid phytoestrogens has been linked to low prevalence of hormone-dependent cancers such as breast and prostate cancer, and heart disease. The isoflavones resemble endogenous estradiol in structure, and have been shown to display weak estrogenic activity. Novogen Limited is pioneering the development of novel drug candidates based on isoflavones. This collaborative research project deals with the development o ....Synthesis of new heterocyclic analogues of isoflavones. Intake of high dietary isoflavonoid phytoestrogens has been linked to low prevalence of hormone-dependent cancers such as breast and prostate cancer, and heart disease. The isoflavones resemble endogenous estradiol in structure, and have been shown to display weak estrogenic activity. Novogen Limited is pioneering the development of novel drug candidates based on isoflavones. This collaborative research project deals with the development of synthetic methodologies for the preparation of new analogues of isoflavone metabolites as potential drug candidates. The target compounds will be evaluated for possible therapeutic use by the industry partner.Read moreRead less
Synthesis of pyrroloquinoline analogues of isoflavone metabolites. Cancer and heart disease are the two main diseases that affect our society indiscriminately and put enormous drains on healthcare resources. The intake of high dietary isoflavonoid phytoestrogens has been linked to low prevalence of cancers and heart disease. Novogen Limited is pioneering the development of novel drug candidates based on phytoestrogen metabolites. This collaborative research project deals with the development ....Synthesis of pyrroloquinoline analogues of isoflavone metabolites. Cancer and heart disease are the two main diseases that affect our society indiscriminately and put enormous drains on healthcare resources. The intake of high dietary isoflavonoid phytoestrogens has been linked to low prevalence of cancers and heart disease. Novogen Limited is pioneering the development of novel drug candidates based on phytoestrogen metabolites. This collaborative research project deals with the development of synthetic methodologies for the preparation of new analogues of phytoestrogen metabolites as potential drug candidates. The target compounds will be evaluated for possible therapeutic use by the industry partner.Read moreRead less
A single vaccine for influenza and pneumonia. Influenza and bacterial pneumonia collaborate to kill millions of people each year. This project aims to develop a single vaccine that will provide long-lasting protection against both influenza and pneumonia.
The development of mass spectrometry techniques for mapping post-translational modifications in the wheat pathogen Stagonospora nodorum. The fungus Stagonospora nodorum is a significant pathogen of wheat causing in excess of $100 million dollars in yield losses per annum in Australia. This project will develop new analytical methods that can be used to detect important protein modifications in Stagonospora nodorum with the goal of securing Australia's wheat supply.
Engaging science students' hearts and minds: Researching science teachers' professional learning in the development of contemporary understandings of scientific literacy. This project will develop, support and value the work of science teachers in developing students' scientific literacy and share the subsequent knowledge gains in the educational community to positively advance quality teaching and learning in school science. Improving science teaching and learning hinges on offering new ways of ....Engaging science students' hearts and minds: Researching science teachers' professional learning in the development of contemporary understandings of scientific literacy. This project will develop, support and value the work of science teachers in developing students' scientific literacy and share the subsequent knowledge gains in the educational community to positively advance quality teaching and learning in school science. Improving science teaching and learning hinges on offering new ways of responding to the problems inherent in teaching science in the 21st century. By supporting and encouraging the creative and innovative ideas, concepts and approaches to quality science teaching and learning embedded in teachers' professional learning the development of the critical knowledge for challenging the status-quo will be advanced.Read moreRead less
Comparative Analysis of Early Intervention Programs for Young Children with Autism. This project will contribute valuable information on how agencies and governments nationally and overseas can cater for a rapidly growing number of students identified with autism. Two early intervention programs - home-based and centre-based - for young children with autism and their families will be compared to each other and a control group. Through promoting strong family knowledge about autism, strategies fo ....Comparative Analysis of Early Intervention Programs for Young Children with Autism. This project will contribute valuable information on how agencies and governments nationally and overseas can cater for a rapidly growing number of students identified with autism. Two early intervention programs - home-based and centre-based - for young children with autism and their families will be compared to each other and a control group. Through promoting strong family knowledge about autism, strategies for managing a young child with autism (e.g., communication, social skills), plus fostering inter-family and community links, families will be empowered to promote healthy outcomes for their young child.Read moreRead less
The Design and Development of the Next Generation Anti-HIV Drugs. This medicinal chemistry project will develop new computer-aided modelling techniques for drug design and development and will then apply them to the design of new therapeutics for the treatment of HIV-1/AIDS. Once developed, these new techniques can also be applied to other disease targets including various cancers, where specific proteins have been identified as causative. This research will also contribute to the education of y ....The Design and Development of the Next Generation Anti-HIV Drugs. This medicinal chemistry project will develop new computer-aided modelling techniques for drug design and development and will then apply them to the design of new therapeutics for the treatment of HIV-1/AIDS. Once developed, these new techniques can also be applied to other disease targets including various cancers, where specific proteins have been identified as causative. This research will also contribute to the education of young scientists, training them in cutting-edge research skills.Read moreRead less
Intervention in the Number Learning of Low-Attaining 3rd- and 4th-Graders. In recent years, school systems both in Australia and elsewhere in the world have placed increased emphasis on numeracy. Nevertheless, significant numbers of students finish primary school without successfully learning basic arithmetic. These students have little chance of catching up this learning during the secondary school years and of becoming numerate adults. Australia has pioneered the development of intervention pr ....Intervention in the Number Learning of Low-Attaining 3rd- and 4th-Graders. In recent years, school systems both in Australia and elsewhere in the world have placed increased emphasis on numeracy. Nevertheless, significant numbers of students finish primary school without successfully learning basic arithmetic. These students have little chance of catching up this learning during the secondary school years and of becoming numerate adults. Australia has pioneered the development of intervention programs in the early years of school but there are virtually no established intervention programs in the Years 3-6 range. The project involves the use of innovative methodologies and collaboration with teachers to research and develop successful intervention programs.Read moreRead less
Positive Pathways to Reading for Disadvantaged Children: Identifying Psychosocial Antecedents and Implementing Effective Intervention to Enhance Literacy, Self-concept, and Motivation. Early intervention to combat reading difficulties in primary schools is vital given the pervasive long-term academic and mental health consequences. Consistent with National Research Priorities (Promoting/maintaining good health/well-being),our research offers important educational/socio-economic benefits by: enri ....Positive Pathways to Reading for Disadvantaged Children: Identifying Psychosocial Antecedents and Implementing Effective Intervention to Enhance Literacy, Self-concept, and Motivation. Early intervention to combat reading difficulties in primary schools is vital given the pervasive long-term academic and mental health consequences. Consistent with National Research Priorities (Promoting/maintaining good health/well-being),our research offers important educational/socio-economic benefits by: enriching disadvantaged children's reading achievement, promoting psychosocial adjustment and life potential, and elucidating multiplier effects of the intervention on volunteers administering the intervention, home life, and school engagement. Synergies between substantive research, methodological rigour, and practice will ensure real solutions and a research framework that will make a substantial contribution to Australia's future.Read moreRead less