Development of mock circulatory system for complex haemodynamic modelling. This project aims to develop a unique mock experimental system to study blood flow dynamics in anatomically realistic coronary artery phantoms. The field of cardiology involves complex fluid dynamic problems, which require the expertise of the fluid dynamics engineer to understand the hemodynamics. Significant innovation in manufacturing and experimental measurement methodologies will be required to develop accurate model ....Development of mock circulatory system for complex haemodynamic modelling. This project aims to develop a unique mock experimental system to study blood flow dynamics in anatomically realistic coronary artery phantoms. The field of cardiology involves complex fluid dynamic problems, which require the expertise of the fluid dynamics engineer to understand the hemodynamics. Significant innovation in manufacturing and experimental measurement methodologies will be required to develop accurate models, which will be designed to allow the partner organisation to undertake further hemodynamic research.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE140100085
Funder
Australian Research Council
Funding Amount
$300,000.00
Summary
Micro/Nanofluidic Characterisation Facility. Micro/nanofluidic characterisation facility: Microfluidics promises to enable diagnosis of medical diseases using devices which perform laboratory experiments but on a scale which means the entire system can be hand-held. Whilst the fabrication of miniaturised fluidic channels is well established, the challenge is to bring additional functions onto the chip reducing the reliance on external pumps and electronics. This facility will allow the character ....Micro/Nanofluidic Characterisation Facility. Micro/nanofluidic characterisation facility: Microfluidics promises to enable diagnosis of medical diseases using devices which perform laboratory experiments but on a scale which means the entire system can be hand-held. Whilst the fabrication of miniaturised fluidic channels is well established, the challenge is to bring additional functions onto the chip reducing the reliance on external pumps and electronics. This facility will allow the characterisation of technologies which address on-chip sample preparation using pulsed ultrasonic waves, filtration and pumping using nanofluidic structures, and detection using on-chip circuitry. As such the facility will have the capability to directly address the challenges which must be met to allow diagnosis in rural underprivileged areas. Read moreRead less
Australian Laureate Fellowships - Grant ID: FL150100019
Funder
Australian Research Council
Funding Amount
$3,041,282.00
Summary
Precision laser levitation for quantum metrology and gravitational sensing. Precision laser levitation for quantum metrology and gravitational sensing: This fellowship project aims to levitate macroscopic objects using only laser beams, to provide a new tool to test physics theories. Strong laser beams can exert sufficient force to counteract gravity and make an object levitate. In contrast to other forms of levitation, laser levitation is scatter-free and can preserve system coherence. It has s ....Precision laser levitation for quantum metrology and gravitational sensing. Precision laser levitation for quantum metrology and gravitational sensing: This fellowship project aims to levitate macroscopic objects using only laser beams, to provide a new tool to test physics theories. Strong laser beams can exert sufficient force to counteract gravity and make an object levitate. In contrast to other forms of levitation, laser levitation is scatter-free and can preserve system coherence. It has superior optical and mechanical quality factors and complete information of the system dynamics is retained. This allows laser levitation to be turned into a highly controllable and ultra-sensitive device capable of detecting minute environmental changes. This research aims to probe the relationship between quantum and gravitational physics and develop laser levitation into a precision instrument for the sensing of gravity. Laser levitation has the potential to be developed into technology for mineral exploration and environmental sensing.Read moreRead less
Coherent Laser Levitation for Precision Sensing and Enabling Science. When light collides with matter, it may exert a force called radiation pressure. This project aims to use radiation pressure to levitate a small mirror. Using a tripod of laser beams, it is possible to levitate and trap the mirror in a stable position. Radiation pressure has been used before to levitate, but previous work has always involved scattering light from the levitating object. This project proposes the use of a high q ....Coherent Laser Levitation for Precision Sensing and Enabling Science. When light collides with matter, it may exert a force called radiation pressure. This project aims to use radiation pressure to levitate a small mirror. Using a tripod of laser beams, it is possible to levitate and trap the mirror in a stable position. Radiation pressure has been used before to levitate, but previous work has always involved scattering light from the levitating object. This project proposes the use of a high quality mirror, allowing the collection of the reflected light and the accurate measurement and control of the position of the mirror as it floats on the laser beams. Using the unique properties of the floating mirror, it will be possible to search for signatures of quantum gravity and develop tools for ultra-precision metrology.Read moreRead less
Acoustic single cell traps: Understanding the woods by examining the trees. This project aims to define the underlying physics behind the manipulation of individual cells in a microfluidic chip using acoustic forces. The technology investigated would offer biomedical researchers a unique capability: that of tracking individual cell responses. It is known for example that drug resistance and latency emerge from small sub-populations of cells, so crucial information is lost when cells are studied ....Acoustic single cell traps: Understanding the woods by examining the trees. This project aims to define the underlying physics behind the manipulation of individual cells in a microfluidic chip using acoustic forces. The technology investigated would offer biomedical researchers a unique capability: that of tracking individual cell responses. It is known for example that drug resistance and latency emerge from small sub-populations of cells, so crucial information is lost when cells are studied at a population level. To trap single cells, the acoustic wavelength excited must be reduced to the order of a cell diameter. By enabling the analysis of different responses due to subtle cell difference, information pertinent to infection pathways and drug response could be gathered.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE150100094
Funder
Australian Research Council
Funding Amount
$400,000.00
Summary
Development of a world-class facility for three dimensional dynamic testing. Development of a world-class facility for three dimensional dynamic testing: This project aims to establish a world-class facility for multi-directional dynamic testing. Currently there are no such facilities in Australia. The ability to recreate dynamic motion in all available degrees-of-freedom opens up enormous fields of research not currently possible in Australia. This includes such areas as vibration testing, mate ....Development of a world-class facility for three dimensional dynamic testing. Development of a world-class facility for three dimensional dynamic testing: This project aims to establish a world-class facility for multi-directional dynamic testing. Currently there are no such facilities in Australia. The ability to recreate dynamic motion in all available degrees-of-freedom opens up enormous fields of research not currently possible in Australia. This includes such areas as vibration testing, materials testing, biomechanics and human factors, blast and earthquake simulations, field robotics, automotive safety research, flight/vehicle simulation, and marine applications including sloshing of liquids and liquefaction of fines. In conjunction with a 3D laser doppler system this facility will be unique in the world for dynamic mechanical testing.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE120102906
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Topology optimisation for advanced engineered nanostructures. Advanced technological innovation requires extraordinary material properties, which can be generated directly from engineered nanostructures by manipulating surface plasmon resonances. The project will develop a new computational method for nanostructural design and expect to benefit aerospace, biomedical, optical and energy engineering fields.
Enhanced sensitivity of electrospray ionization mass spectrometry. Enhanced sensitivity of electrospray ionization mass spectrometry. This project aims to enhance the sensitivity of nano-electrospray ionization mass spectrometry (nanoESI-MS) by an order of magnitude by simultaneously overcoming the two interdependent limitations in ion generation and transmission efficiency. This project will design glass capillaries and tubes with complex structures to enable both multiplexing ion generation fr ....Enhanced sensitivity of electrospray ionization mass spectrometry. Enhanced sensitivity of electrospray ionization mass spectrometry. This project aims to enhance the sensitivity of nano-electrospray ionization mass spectrometry (nanoESI-MS) by an order of magnitude by simultaneously overcoming the two interdependent limitations in ion generation and transmission efficiency. This project will design glass capillaries and tubes with complex structures to enable both multiplexing ion generation from a single capillary and geometrically matching the bore of the tube collecting the emitted ion plume. NanoESI-MS has become an indispensable analytical tool for proteomics and synthetic chemistry. The significant enhancement of nanoESI-MS sensitivity in this project is expected to accelerate progress in disease research, biomarker discovery and drug development.Read moreRead less
Atomic forces for sorting ultrabright nanodiamonds. This project aims to sort fluorescent nanodiamonds according to their brightness using atomic radiation pressure. Fluorescent nanodiamonds can overcome all limitations associated with conventional fluorescent bio-labels. While readily available, their brightness varies greatly, so a method for yielding high-quality material with consistent brightness is needed. This project combines techniques from laser manipulation of cold atoms and microflui ....Atomic forces for sorting ultrabright nanodiamonds. This project aims to sort fluorescent nanodiamonds according to their brightness using atomic radiation pressure. Fluorescent nanodiamonds can overcome all limitations associated with conventional fluorescent bio-labels. While readily available, their brightness varies greatly, so a method for yielding high-quality material with consistent brightness is needed. This project combines techniques from laser manipulation of cold atoms and microfluidics to create an optofluidic method of particle separation. The proposed device could sort nanodiamonds more than a billion times faster than active sorting techniques. This is expected to lead to better tools for bio-imaging and bio-manipulation.Read moreRead less