How do vortices live in spatio-temporally complex flows? The project aims to understand the fundamental mechanism of vortices occurring in flows involving spatio-temporal complexity, by using the combination of dynamical systems theory and asymptotic analysis. This innovative combined mathematical analysis will be coupled with sophisticated computations to be enabled by the international interdisciplinary collaboration between the Mathematics and Engineering at Australia and Japan. The expected ....How do vortices live in spatio-temporally complex flows? The project aims to understand the fundamental mechanism of vortices occurring in flows involving spatio-temporal complexity, by using the combination of dynamical systems theory and asymptotic analysis. This innovative combined mathematical analysis will be coupled with sophisticated computations to be enabled by the international interdisciplinary collaboration between the Mathematics and Engineering at Australia and Japan. The expected outcomes are breakthroughs in the fundamental understanding of turbulence. This should lead to significant insight into better turbulent modellings used in, for example, wide range of engineering, physiological and geophysical flows.Read moreRead less
Bidirectional Evolutionary Structural Optimization for Transient Problems. Aims: This proposal aims to expand the bidirectional evolutionary structural optimisation (BESO) method for transient mechanical, multiphysical and robotic problems.
Significance: The study will develop new BESO transient algorithms by integrating time-dependent analysis and stepwise design sensitivity in multicriteria and multidisciplinary optimisation.
Expected outcomes: The project will largely broaden the algorithmi ....Bidirectional Evolutionary Structural Optimization for Transient Problems. Aims: This proposal aims to expand the bidirectional evolutionary structural optimisation (BESO) method for transient mechanical, multiphysical and robotic problems.
Significance: The study will develop new BESO transient algorithms by integrating time-dependent analysis and stepwise design sensitivity in multicriteria and multidisciplinary optimisation.
Expected outcomes: The project will largely broaden the algorithmic scope of BESO and enables it to solve more extensive real-life problems with time-varying nature.
Benefits include a new BESO design framework and computer program, as well as a series of novel designs, potentially being implemented for aerospace, automotive, biomedical, mechanical, civil and mechatronic applications.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE230101196
Funder
Australian Research Council
Funding Amount
$439,012.00
Summary
Data-Driven Design for 3D Printed Materials with Tailored Fracture Response. Fracture is the main source of material failure and may cause serious engineering disasters and even death. This project aims to develop a Data-Driven Design System that intelligently optimizes local materials and architectures for heterogeneous structures with desired fracture response, and enhancing their mechanical fracture properties including stiffness, strength, toughness, and failure displacement. It will open up ....Data-Driven Design for 3D Printed Materials with Tailored Fracture Response. Fracture is the main source of material failure and may cause serious engineering disasters and even death. This project aims to develop a Data-Driven Design System that intelligently optimizes local materials and architectures for heterogeneous structures with desired fracture response, and enhancing their mechanical fracture properties including stiffness, strength, toughness, and failure displacement. It will open up a new and promising research field in mechanics and data-driven science that deals with intractable inverse problems in broad engineering fields. Economic, high-performance, and customized 3D printed structural materials will be generated to benefit national corporations and enterprises and meet the high-end industry needs.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE230100400
Funder
Australian Research Council
Funding Amount
$425,963.00
Summary
Fallopian tube on-a-chip for understanding mammalian reproduction. This project aims to reveal the fundamental physics and biology of mammalian reproduction by engineering the first comprehensive 3D culture model of the fallopian tube. The project expects to generate significant new knowledge about the exact role of the fallopian tube anatomy and physiology on the formation and function of epithelial tissue, using innovative approaches to simultaneously measure the full dynamics of epithelial ce ....Fallopian tube on-a-chip for understanding mammalian reproduction. This project aims to reveal the fundamental physics and biology of mammalian reproduction by engineering the first comprehensive 3D culture model of the fallopian tube. The project expects to generate significant new knowledge about the exact role of the fallopian tube anatomy and physiology on the formation and function of epithelial tissue, using innovative approaches to simultaneously measure the full dynamics of epithelial cell activity and sperm motion. The expected outcome of the project is to reveal the cooperative role of sperm, egg and epithelial tissue on fertilisation. This should provide significant benefits, such as important biophysical insights into mammalian reproduction and new research tools to replace animal models.Read moreRead less
Impact of roughness on adverse pressure gradient turbulent boundary layers. This project aims to develop a novel technique for measuring time-resolved fluid velocity vector fields in high-speed flows to investigate rough wall turbulence in adverse pressure gradient environments in unprecedented detail. By using this innovative instrument to study these widespread but poorly understood turbulent flows in power generation and transport, the project seeks to generate new knowledge. Expected outcome ....Impact of roughness on adverse pressure gradient turbulent boundary layers. This project aims to develop a novel technique for measuring time-resolved fluid velocity vector fields in high-speed flows to investigate rough wall turbulence in adverse pressure gradient environments in unprecedented detail. By using this innovative instrument to study these widespread but poorly understood turbulent flows in power generation and transport, the project seeks to generate new knowledge. Expected outcomes include the development of a new instrument and fundamental knowledge leading to improved designs with higher efficiencies in power generation and transport, resulting in significant benefits such as increased energy security, reduced greenhouse gas emissions, and improved quality of life for individuals and society.Read moreRead less
Microfluidics to explore the uptake of nanoparticles by endothelial cells. This project aims to develop microfluidic technologies for generating lipid nanoparticles with customised properties and investigating their delivery to endothelial cells under various flow dynamics. The project expects to advance our fundamental knowledge of biophysical and biological mechanisms underlying the uptake of lipid nanoparticles by endothelial cells. Expected outcomes of this project include enhanced delivery ....Microfluidics to explore the uptake of nanoparticles by endothelial cells. This project aims to develop microfluidic technologies for generating lipid nanoparticles with customised properties and investigating their delivery to endothelial cells under various flow dynamics. The project expects to advance our fundamental knowledge of biophysical and biological mechanisms underlying the uptake of lipid nanoparticles by endothelial cells. Expected outcomes of this project include enhanced delivery of nanoparticles to vessel walls. This should provide significant benefits, such as establishing a framework for designing future nano delivery systems, which would benefit Australian biotechnology industries.
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Linkage Infrastructure, Equipment And Facilities - Grant ID: LE240100049
Funder
Australian Research Council
Funding Amount
$1,200,000.00
Summary
In-situ nanomechanical testing for materials under extreme environments. This project aims to establish a state-of-the-art in-situ nanomechanical testing capability for materials under extreme environments. A cutting-edge nanoindentation stage with customisable modules, as well as an optimally configured scanning electron microscope, will enable this capability for the first time in Australia. The expected outcomes will provide valuable insights into how microstructures affect mechanical propert ....In-situ nanomechanical testing for materials under extreme environments. This project aims to establish a state-of-the-art in-situ nanomechanical testing capability for materials under extreme environments. A cutting-edge nanoindentation stage with customisable modules, as well as an optimally configured scanning electron microscope, will enable this capability for the first time in Australia. The expected outcomes will provide valuable insights into how microstructures affect mechanical properties at temperatures ranging from -150 to 1000 °C, strain rates from 10E-5/s to 10E5/s, and liquid environments. The resulting knowledge will guide the development of structural materials that withstand harsh environmental conditions, thereby advancing Australia's advanced manufacturing and sustainable energy sectors.Read moreRead less
Fatigue Life Assessment of Structures under Realistic Loading Conditions. The project will develop a new methodology for the assessment of fatigue life of structures subjected to realistic loading conditions. This new methodology is based on recent advances in experimental techniques which make possible, for the first time, the investigation of the crack opening/closure mechanisms and the crack driving force for large numbers of fatigue cycles (>1 million) of variable amplitude, representative o ....Fatigue Life Assessment of Structures under Realistic Loading Conditions. The project will develop a new methodology for the assessment of fatigue life of structures subjected to realistic loading conditions. This new methodology is based on recent advances in experimental techniques which make possible, for the first time, the investigation of the crack opening/closure mechanisms and the crack driving force for large numbers of fatigue cycles (>1 million) of variable amplitude, representative of real-world applications. The project will expand Australia’s knowledge base and research capabilities in structural life prognosis. It will increase the competitiveness of domestic products and industries, fostering international collaborations and leadership of Australia in this strategically important area of research.Read moreRead less
On the Hunt: Boosting Productivity of Cell Factories by Advanced Searches . This project aims to advance our fundamental understanding of molecular mechanisms underlying protein secretion in yeast, an industrial workhorse and a model organism. It will develop a unique multifaceted research platform to identify and analyse superior yeast strains with the desired traits at the single-cell level. Expected outcomes include a new analytical tool for high-throughput strain analysis and advanced knowle ....On the Hunt: Boosting Productivity of Cell Factories by Advanced Searches . This project aims to advance our fundamental understanding of molecular mechanisms underlying protein secretion in yeast, an industrial workhorse and a model organism. It will develop a unique multifaceted research platform to identify and analyse superior yeast strains with the desired traits at the single-cell level. Expected outcomes include a new analytical tool for high-throughput strain analysis and advanced knowledge of yeast molecular biology that can be applied to improve cell factories for the next generation of fuels, food and pharmaceuticals. This will provide significant economic and social benefits by boosting biotech industry growth, facilitating the transition to a sustainable society and improving Australia’s biosecurity.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE240101027
Funder
Australian Research Council
Funding Amount
$414,000.00
Summary
Deciphering the mechanisms of object manipulation with viscoelastic fluids. This project aims to innovate how tiny objects in mixed samples are sorted using the forces generated by fluids that are both viscous and elastic. The developed technology is expected to break the limitations of conventional methods by automating sample processing and by enabling the sorting capability based on not only size, but also shape and fluid properties. This will meet the growing demand for rapid processing of c ....Deciphering the mechanisms of object manipulation with viscoelastic fluids. This project aims to innovate how tiny objects in mixed samples are sorted using the forces generated by fluids that are both viscous and elastic. The developed technology is expected to break the limitations of conventional methods by automating sample processing and by enabling the sorting capability based on not only size, but also shape and fluid properties. This will meet the growing demand for rapid processing of complex real-world environmental samples. The expected outcomes include new knowledge and techniques for sorting algae and insects from water samples for the assessment of water quality and biodiversity. It is expected to benefit Australians by providing faster, cheaper, and more efficient environmental monitoring methods.Read moreRead less