Linkage Infrastructure, Equipment And Facilities - Grant ID: LE140100085
Funder
Australian Research Council
Funding Amount
$300,000.00
Summary
Micro/Nanofluidic Characterisation Facility. Micro/nanofluidic characterisation facility: Microfluidics promises to enable diagnosis of medical diseases using devices which perform laboratory experiments but on a scale which means the entire system can be hand-held. Whilst the fabrication of miniaturised fluidic channels is well established, the challenge is to bring additional functions onto the chip reducing the reliance on external pumps and electronics. This facility will allow the character ....Micro/Nanofluidic Characterisation Facility. Micro/nanofluidic characterisation facility: Microfluidics promises to enable diagnosis of medical diseases using devices which perform laboratory experiments but on a scale which means the entire system can be hand-held. Whilst the fabrication of miniaturised fluidic channels is well established, the challenge is to bring additional functions onto the chip reducing the reliance on external pumps and electronics. This facility will allow the characterisation of technologies which address on-chip sample preparation using pulsed ultrasonic waves, filtration and pumping using nanofluidic structures, and detection using on-chip circuitry. As such the facility will have the capability to directly address the challenges which must be met to allow diagnosis in rural underprivileged areas. Read moreRead less
Optimizing blood flow in stented arteries: a fluid mechanics approach incorporating optical coherence tomography. Constriction in coronary arterial blood flow is a leading cause of death in Australia. Insertion of stents can rectify this problem but potentially lead to further complications. This project will use medical imaging data to construct computer models to study blood flow and particle motions in coronary arteries and improve stent designs.
The development of particle-depleted regions in dense suspensions of neutrally buoyant particles. We aim to measure the spatial variation of fluid speed and particle speed, and of particle concentration, across and along a pipe into which has been introduced a mixture of said particles and fluid. This problem has significance in mechanical and chemical engineering wherever particle/fluid mixtures are flowing. The expected outcomes are recognition of a major contribution to world research, as w ....The development of particle-depleted regions in dense suspensions of neutrally buoyant particles. We aim to measure the spatial variation of fluid speed and particle speed, and of particle concentration, across and along a pipe into which has been introduced a mixture of said particles and fluid. This problem has significance in mechanical and chemical engineering wherever particle/fluid mixtures are flowing. The expected outcomes are recognition of a major contribution to world research, as well as technological applications; one that motivates us is the blood shear in the bearings of a revolutionary Australian blood pump for cardiac assist that avoids both pivots and magnetic suspension for the single moving part.Read moreRead less
Optimising haemodynamics in complex stented arteries. This project aims to optimise the hemodynamics (blood flow) in coronary arteries with high curvatures and bifurcations. Experience has shown that the build-up of plaque — and the resulting occlusion of blood flow — tends to occur in these complex arterial regions. The most common therapeutic strategy is the insertion of a stent to prop open the artery. However, the nature of the geometry often leads to post-stenting complications such as rest ....Optimising haemodynamics in complex stented arteries. This project aims to optimise the hemodynamics (blood flow) in coronary arteries with high curvatures and bifurcations. Experience has shown that the build-up of plaque — and the resulting occlusion of blood flow — tends to occur in these complex arterial regions. The most common therapeutic strategy is the insertion of a stent to prop open the artery. However, the nature of the geometry often leads to post-stenting complications such as restenosis and thrombosis, ultimately resulting in negative outcomes. In this project, advanced research methods from fluid dynamics and optimisation and control will be used to potentially minimise these highly undesirable effects.Read moreRead less
Flow-induced oscillation in flexible tubes: experimental and numerical investigation of mechanism and onset. We seek to understand when instability arises in flow over very deformable structures. This will help us to design highly flexible structures specifically either to avoid the danger of flow-induced oscillations, which may be damaging (cardiac surgery, sails, parachutes), or in other circumstances to take advantage of them as an innovative way involving no sliding-parts mechanisms to crea ....Flow-induced oscillation in flexible tubes: experimental and numerical investigation of mechanism and onset. We seek to understand when instability arises in flow over very deformable structures. This will help us to design highly flexible structures specifically either to avoid the danger of flow-induced oscillations, which may be damaging (cardiac surgery, sails, parachutes), or in other circumstances to take advantage of them as an innovative way involving no sliding-parts mechanisms to create vibration, or flow pulsation, or sound, or motion (as in swimming-pool cleaners). Confidence in designing with highly flexible tubes will allow minimal resource consumption in manufacture of products to transport fluids, and will allow design use of the flow limitation property, whereby such a tube can control flow-rate.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE180100166
Funder
Australian Research Council
Funding Amount
$637,800.00
Summary
Four-dimensional coherent imaging velocimetry facility for fluid mechanics research. This project aims to enhance understanding of multi-scale fluid flows in engineering, geophysics and biomedicine by delivering a facility for high temporal and spatial resolution, three-dimensional velocity measurements. The four-dimensional, coherent imaging velocimetry facility for fluid mechanics research is aimed at addressing limitations of commercially available imaging systems. It is expected to provide ....Four-dimensional coherent imaging velocimetry facility for fluid mechanics research. This project aims to enhance understanding of multi-scale fluid flows in engineering, geophysics and biomedicine by delivering a facility for high temporal and spatial resolution, three-dimensional velocity measurements. The four-dimensional, coherent imaging velocimetry facility for fluid mechanics research is aimed at addressing limitations of commercially available imaging systems. It is expected to provide unprecedented measurement capabilities with significant benefit to the design, control and modelling of complex fluid flows found in many areas. Applications include the jets used for heating, cooling, mixing, and drug delivery in engineering and pharmacy to the kinematics of sperm and micro-organisms in bio-medicine, and wave-particle flows in geo-physics.Read moreRead less