Suspension flows and particle focusing in curved geometries. The project aims to develop fast predictive tools to investigate suspension flows in curved channels and thin ducts and the effect of channel geometry on the focusing of particles by weight to different regions of the channel. Interaction between particles and fluid in suspension flows is a fundamental problem that is little understood but which is important in a wide range of problems in nature and industry (eg for design of microscal ....Suspension flows and particle focusing in curved geometries. The project aims to develop fast predictive tools to investigate suspension flows in curved channels and thin ducts and the effect of channel geometry on the focusing of particles by weight to different regions of the channel. Interaction between particles and fluid in suspension flows is a fundamental problem that is little understood but which is important in a wide range of problems in nature and industry (eg for design of microscale segregation devices for separation of different cells in a blood sample, and of macroscale devices for separation of mineral particles from crushed ore). At present, the description of these processes is qualitative, with quantitative understanding seen as a challenge without intensive computation. The project plans to develop, solve and validate mathematical models to give a quantitative understanding of these processes.Read moreRead less
Prediction of inertial particle focusing in curved microfluidic ducts. This project aims to develop mathematical models to predict migration of particles suspended in flow through curved microfluidic ducts and their focusing by size to different regions in the cross-section of the duct. New knowledge in mathematics and engineering will be generated through models that capture the two-way force balance between fluid and particles and by a novel use of asymptotics for computational efficiency. Exp ....Prediction of inertial particle focusing in curved microfluidic ducts. This project aims to develop mathematical models to predict migration of particles suspended in flow through curved microfluidic ducts and their focusing by size to different regions in the cross-section of the duct. New knowledge in mathematics and engineering will be generated through models that capture the two-way force balance between fluid and particles and by a novel use of asymptotics for computational efficiency. Expected outcomes are understanding of the physics that drives particle migration and the parameters that may be used to control particle focusing. This will benefit design and operation of microfluidic devices for particle sorting as required for "liquid biopsy", the isolation of cancer cells in a routine blood sample.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE130100031
Funder
Australian Research Council
Funding Amount
$333,684.00
Summary
Mathematical modelling of the complex mechanics of biological materials and their role in tissue function and development. The mechanics of biological materials is complicated because they consist of many components such as fibres, proteins and polymers. We aim to use mathematical tools to understand how these components interact in tissues such as the spinal disc which will aid the development of new treatments to reverse the effects of injury, disease or aging.
Optimal electromaterial structures for energy applications. This project aims to develop new mathematical and modelling approaches to determine optimal configurations and parameters for material structures created from three-dimensional printing of combined metals and electromaterials. Electromaterials are needed for sustainable energy, but solving coupled-systems of highly nonlinear governing equations is needed for optimal control of spatial arrangement and composition in nano and micro-struct ....Optimal electromaterial structures for energy applications. This project aims to develop new mathematical and modelling approaches to determine optimal configurations and parameters for material structures created from three-dimensional printing of combined metals and electromaterials. Electromaterials are needed for sustainable energy, but solving coupled-systems of highly nonlinear governing equations is needed for optimal control of spatial arrangement and composition in nano and micro-structural domains. Dealing with this mathematical complexity is critical to developing high efficiency energy generation and gas storage systems. This is expected to enhance transport mechanisms within electrochemical devices and create opportunities for industry to use electrofunctional materials.Read moreRead less
Quantifying yeast cell mechanisms: filamentous growth and biofilm formation. This project aims to quantify the cellular mechanisms of yeast growth to advance our understanding of these organisms and support strategies to prevent and treat disease. Although yeasts are some of the most studied organisms in biology, their modes of filamentous growth and biofilm formation are not fully understood. Yeasts such as the Candida species cause potentially lethal infections through filamentous invasion of ....Quantifying yeast cell mechanisms: filamentous growth and biofilm formation. This project aims to quantify the cellular mechanisms of yeast growth to advance our understanding of these organisms and support strategies to prevent and treat disease. Although yeasts are some of the most studied organisms in biology, their modes of filamentous growth and biofilm formation are not fully understood. Yeasts such as the Candida species cause potentially lethal infections through filamentous invasion of tissues. The project plans to develop methods to quantify the mechanisms driving these growth processes. These methods will be designed to permit classification and selection of strain-specific properties of yeasts, providing a deeper understanding of the mechanisms controlling cellular and colonial morphology in the growth of Saccharomyces cerevisiae, the most important yeast in both biotechnology and bioscience.Read moreRead less
Integrating rifts and swell in the mathematics of ice shelf disintegration. Antarctic ice-shelf disintegrations have the alarming potential to cause rapid sea level rise, through accelerated discharge of the Antarctic Ice Sheet and initiating runaway Ice Sheet destabilisations. The project aims to develop a mathematical model of swell-induced ice-shelf vibrations in a coupled ocean–shelf 3D framework, focusing on interactions between vibrations and the rift networks that characterise outer shelf ....Integrating rifts and swell in the mathematics of ice shelf disintegration. Antarctic ice-shelf disintegrations have the alarming potential to cause rapid sea level rise, through accelerated discharge of the Antarctic Ice Sheet and initiating runaway Ice Sheet destabilisations. The project aims to develop a mathematical model of swell-induced ice-shelf vibrations in a coupled ocean–shelf 3D framework, focusing on interactions between vibrations and the rift networks that characterise outer shelf margins before disintegration. Accurate, efficient solutions will be developed by fusing powerful approximation theories, and validated by numerical solutions. The model will be combined with state-of-the-art data to predict trends in Antarctica’s remaining ice shelves and indicate potential future disintegrations.Read moreRead less
Flow structures and transport: predictability and control. Moving flow structures (the boundary of an eddy, the flow interface between two fluids) are crucial in fluid mixing and in the transport of heat, pollutants and nutrients. This project will analyse their roles in improving predictions of spreading extents and rates for geophysical-scale problems, and in controlling transport at the micro-scale. Inaccuracies in currently available numerical diagnostics for transport prediction will be com ....Flow structures and transport: predictability and control. Moving flow structures (the boundary of an eddy, the flow interface between two fluids) are crucial in fluid mixing and in the transport of heat, pollutants and nutrients. This project will analyse their roles in improving predictions of spreading extents and rates for geophysical-scale problems, and in controlling transport at the micro-scale. Inaccuracies in currently available numerical diagnostics for transport prediction will be comprehensively evaluated via comparison with recent exact models. Analytical methods for quantifying transport under unsteady flow protocols will be developed, and used to answer questions on controlling transport in microfluidic applications in conjunction with experimentalists.Read moreRead less
Shining the light on geometry of microstructured optical fibres. A fast, powerful computer code using new mathematical models and techniques will be produced and experimentally validated, for use in development of novel microstructured optical fibres for telecommunications and other applications. This code will reduce the time-consuming and expensive experimental iteration needed for development of these fibres.
Mathematics the key to modern glass and polymer fibre technology. This project aims to develop fully coupled flow and energy models to determine the preform structure and fibre-drawing parameters needed to fabricate a desired microstructured optical fibre by stretching of the preform to a fibre. It will focus on polymer to develop a non-Newtonian flow model, which can handle the subset of Newtonian glass fibre drawing. It will develop fast, powerful three-dimensional predictive tools to solve th ....Mathematics the key to modern glass and polymer fibre technology. This project aims to develop fully coupled flow and energy models to determine the preform structure and fibre-drawing parameters needed to fabricate a desired microstructured optical fibre by stretching of the preform to a fibre. It will focus on polymer to develop a non-Newtonian flow model, which can handle the subset of Newtonian glass fibre drawing. It will develop fast, powerful three-dimensional predictive tools to solve the models and experimentally validate solutions. This work will direct future design of microstructured optical fibres to empower next-generation optical-fibre technologies. Expected outcomes are fibre designs for telecommunications, medicine, biotechnology, sensing and imaging.Read moreRead less