The prediction of sleep/wake behaviour based on physiological and social factors. The prevalence of shiftwork has increased in Australia over the last few decades. Shiftworkers obtain less sleep, have greater difficulty maintaining good relationships, have poorer health, and are more likely to be injured at work than others. Using the largest dataset of its kind, we will substantially contribute to understanding the relationships between work hours, sleep, performance and safety. Ultimately, the ....The prediction of sleep/wake behaviour based on physiological and social factors. The prevalence of shiftwork has increased in Australia over the last few decades. Shiftworkers obtain less sleep, have greater difficulty maintaining good relationships, have poorer health, and are more likely to be injured at work than others. Using the largest dataset of its kind, we will substantially contribute to understanding the relationships between work hours, sleep, performance and safety. Ultimately, the project will answer a question critical to workplace safety - how much time off between shifts is needed to be alert and safe at work? The project will also produce tools to help industry design fatigue-friendly rosters, improving the safety, productivity and general well-being of shiftworkers in Australia and overseas.Read moreRead less
Designing microarray experiments. Microarrays are powerful tools for surveying the expression levels of many thousands of genes simultaneously. They belong to the new genomics technologies which have important applications in the biological, pharmaceutical and agricultural sciences. There are many sources of uncertainty in microarray experimentation and good statistical designs are essential for ensuring that the effects of interest to scientists are accurately and precisely measured. This Pr ....Designing microarray experiments. Microarrays are powerful tools for surveying the expression levels of many thousands of genes simultaneously. They belong to the new genomics technologies which have important applications in the biological, pharmaceutical and agricultural sciences. There are many sources of uncertainty in microarray experimentation and good statistical designs are essential for ensuring that the effects of interest to scientists are accurately and precisely measured. This Project will develop novel designs for microarray experiments and focus on the advancement of topics crucial to Australia's success in technological research.
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Mathematical and mechanical models in nano-engineering and nanomedicine. The major environmental problems generated from global warming and the major human health problems, like cancer and diabetes, if they are to be solved at all, will most likely be resolved making use of advances in nanobiotechnology. This proposal will position Australia as a leader in the modelling of nanodevices such as gigahertz oscillators, nano-electromagnets, nanosensors, nanosyringes and nanoporous media suitable for ....Mathematical and mechanical models in nano-engineering and nanomedicine. The major environmental problems generated from global warming and the major human health problems, like cancer and diabetes, if they are to be solved at all, will most likely be resolved making use of advances in nanobiotechnology. This proposal will position Australia as a leader in the modelling of nanodevices such as gigahertz oscillators, nano-electromagnets, nanosensors, nanosyringes and nanoporous media suitable for hydrogen storage and gas separation, which will lead to new technologies and commercial spin-offs that will be of major benefit to this country. The applicants will develop a range of topics in nano-engineering and nanomedicine, training a team that will provide the next generation of researchers in these vital areas.Read moreRead less
Saddlepoint approximation, likelihood analysis and ancestral graphs for strong and weak natural selection, genetic drift and population subdivision. Building new research strength in theoretical population genetics and related statistical techniques will enhance Australia's capability in harnessing the power of post-genomic information. Sophisticated statistical techniques that make smart use of genetic data are being developed in this project. The extent to which natural selection and migrati ....Saddlepoint approximation, likelihood analysis and ancestral graphs for strong and weak natural selection, genetic drift and population subdivision. Building new research strength in theoretical population genetics and related statistical techniques will enhance Australia's capability in harnessing the power of post-genomic information. Sophisticated statistical techniques that make smart use of genetic data are being developed in this project. The extent to which natural selection and migration affect current genetic polymorphism on a population level can be quantified using these new methods. New modeling provides a rigorous foundation with which to construct inference techniques currently beyond computational approaches to the data. Assessing selective effects on genetic mutations associated with human disease will be a consequence of this new statistical methodology.Read moreRead less