Identifying The Pathological Mechanism Of PCDH19-Girls Clustering Epilepsy
Funder
National Health and Medical Research Council
Funding Amount
$523,988.00
Summary
Changes in the PCDH19 gene are a relatively common cause of epilepsy. To better understand the basis of this disorder, we have developed unique mouse models that mimic the genetic changes and symptoms of this condition. We will perform careful analysis of brain development in these models to determine the primary cause of this condition. These experiments will create greater understanding of how changes in PCDH19 cause epilepsy in girls and facilitate the development of new treatments.
Special Research Initiatives - Grant ID: SR0354727
Funder
Australian Research Council
Funding Amount
$20,000.00
Summary
Mathematics for Government, Industry and Community -- The *Magic* Network. The *Magic* network will promote the use of mathematics by government, industry and community to analyse real problems and implement practical solutions. It will connect the most promising young Australian mathematicians to experienced researchers with strong research teams linked directly to the broader community. Our program will demand research excellence, emphasise a sustainable society, support outstanding young mat ....Mathematics for Government, Industry and Community -- The *Magic* Network. The *Magic* network will promote the use of mathematics by government, industry and community to analyse real problems and implement practical solutions. It will connect the most promising young Australian mathematicians to experienced researchers with strong research teams linked directly to the broader community. Our program will demand research excellence, emphasise a sustainable society, support outstanding young mathematicians and create opportunities for promising postgraduate students. We will offer scholarships for professional development and fund research visits and exchanges. *Magic* will provide tangible incentives for young Australian mathematicians and a new generation of researchers and research leaders.Read moreRead less
ARC Complex Open Systems Research Network. Complexity is the common frontier in the physical, biological and social sciences. This Network will link specialists in all three sciences through five generic conceptual and mathematical theme activities. It will promote research into how subsystems self-organise into new emergent structures when assembled into an open, non-equilibrium system. Outcomes will include new technologies and software tools and deeper understanding of fundamental questions i ....ARC Complex Open Systems Research Network. Complexity is the common frontier in the physical, biological and social sciences. This Network will link specialists in all three sciences through five generic conceptual and mathematical theme activities. It will promote research into how subsystems self-organise into new emergent structures when assembled into an open, non-equilibrium system. Outcomes will include new technologies and software tools and deeper understanding of fundamental questions in science. An essential function of the network will be introducing researchers end users to new tools and broadening the horizons of graduate students.Read moreRead less
Understanding The Causes Of Childhood Congenital Anomalies Of The Kidney And Urinary Tract
Funder
National Health and Medical Research Council
Funding Amount
$609,748.00
Summary
Congenital anomalies of the kidney and urinary tract (CAKUT) is a common cause of renal failure in children. The majority of patients with CAKUT do not know the underlying cause of their renal anomalies. In this proposal we will characterise the developmental events that are perturbed in three mouse models of CAKUT and identify the causal gene responsible in each mouse model. We will translate this information to the clinic by screening patients with CAKUT for mutations in these newly identified ....Congenital anomalies of the kidney and urinary tract (CAKUT) is a common cause of renal failure in children. The majority of patients with CAKUT do not know the underlying cause of their renal anomalies. In this proposal we will characterise the developmental events that are perturbed in three mouse models of CAKUT and identify the causal gene responsible in each mouse model. We will translate this information to the clinic by screening patients with CAKUT for mutations in these newly identified genes.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0347797
Funder
Australian Research Council
Funding Amount
$263,000.00
Summary
A Versatile High-resolution X-ray Diffractometer for Materials Research. The aim of this project is to establish a state-of-the-art triple-axis x-ray diffraction facility capable of non-destructively analysing complex semiconductor materials and structures investigated by all Australian semiconductor-growing groups. Growers and device engineers will be able to control growth processes accurately and correlate device performance with structural analysis. Modern triple-axis instruments can also b ....A Versatile High-resolution X-ray Diffractometer for Materials Research. The aim of this project is to establish a state-of-the-art triple-axis x-ray diffraction facility capable of non-destructively analysing complex semiconductor materials and structures investigated by all Australian semiconductor-growing groups. Growers and device engineers will be able to control growth processes accurately and correlate device performance with structural analysis. Modern triple-axis instruments can also be used for high-resolution texture analysis and surface reflectivity measurements on numerous types of materials. Thus chemists, geologists, and materials scientists with interests outside of the semiconductor growth community will gain substantial benefit from this instrument for the investigation of materials of technological and economic importance.Read moreRead less
Modelling and estimation methods for discrete multi-dimensional systems. Multi-dimensional signal processing plays a role in a variety of application areas, ranging from remote sensing for environmental monitoring and geological mapping, to medical imaging and the automatic control of industrial processes. The success of the project will provide mathematical tools for the advancement of the state-of-the-art in these broad areas.
Mathematical and computational models for agrichemical retention on plants. Mathematical and computational models for agrichemical retention on plants. This project aims to build interactive software that simulates agrichemical spraying for multiple virtual plants reconstructed from scanned data. Mathematical modelling and computer simulation could offer an alternative to expensive experimental programs for agrichemical spraying of plants. This project will use contemporary fluid mechanics to bu ....Mathematical and computational models for agrichemical retention on plants. Mathematical and computational models for agrichemical retention on plants. This project aims to build interactive software that simulates agrichemical spraying for multiple virtual plants reconstructed from scanned data. Mathematical modelling and computer simulation could offer an alternative to expensive experimental programs for agrichemical spraying of plants. This project will use contemporary fluid mechanics to build practical mathematical models for droplet impaction, spreading and evaporation on leaf surfaces, and experimentally calibrate and validate the models. The software is expected to drive the development of agrichemical products that increase retention, minimise environmental impacts, and reduce costs for end-users.Read moreRead less
Dating Murujuga's Rock Art: new scientific approaches. The Dampier Archipelago is on Australia's National Heritage List because of its significant rock art and stone features. Known as Murujuga to its traditional custodians, this land- and seascape has over 1 million art works. While the scientific and cultural significance of this area is acknowledged, we still know little about the age of this landscape, the regional palaeoclimatology, and the timing and intensity of rock art production since ....Dating Murujuga's Rock Art: new scientific approaches. The Dampier Archipelago is on Australia's National Heritage List because of its significant rock art and stone features. Known as Murujuga to its traditional custodians, this land- and seascape has over 1 million art works. While the scientific and cultural significance of this area is acknowledged, we still know little about the age of this landscape, the regional palaeoclimatology, and the timing and intensity of rock art production since Aboriginal people moved into this region 50,000 years ago. This project will develop new scientific approaches to direct-dating engravings and stone features, reconstruct climate from geological proxies, and model voyaging opportunities as this unique cultural estate transformed to an archipelago.Read moreRead less
Deep ocean thermodynamics and climate change. This project aims to obtain new insights into the thermodynamic and transport properties of mixtures containing water, particularly at high pressures, that impact directly on our understanding of climate change processes. The project will involve the use of a polarisable potential for water which has recently been demonstrated to yield predictions of high accuracy. It will be used to model saline water mixtures containing carbon dioxide, resulting in ....Deep ocean thermodynamics and climate change. This project aims to obtain new insights into the thermodynamic and transport properties of mixtures containing water, particularly at high pressures, that impact directly on our understanding of climate change processes. The project will involve the use of a polarisable potential for water which has recently been demonstrated to yield predictions of high accuracy. It will be used to model saline water mixtures containing carbon dioxide, resulting in valuable data for thermodynamic properties of the world's oceans. These data are of crucial importance for accurate climate change predictions and as such the project will have an important impact on understanding our changing environment.Read moreRead less
Wavelet approaches for solving nonlinear dynamic systems in process engineering. The success of the proposed project will enable us to obtain more accurate numerical solutions for the nonlinear dynamical systems arising from process engineering. This ensures the potential for understanding and optimising industrial and engineering processes. Hence, a wide range of processing industries in Australia, such as agricultural chemicals, mineral processing, food, detergents, pharmaceuticals, ceramics ....Wavelet approaches for solving nonlinear dynamic systems in process engineering. The success of the proposed project will enable us to obtain more accurate numerical solutions for the nonlinear dynamical systems arising from process engineering. This ensures the potential for understanding and optimising industrial and engineering processes. Hence, a wide range of processing industries in Australia, such as agricultural chemicals, mineral processing, food, detergents, pharmaceuticals, ceramics and specialty chemicals will benefit from the results of this project. This will ensure globally competitive production and, therefore, greater contributions to the Australian economy.Read moreRead less