Endocrine And Molecular Regulation Of Placental CRH Expression
Funder
National Health and Medical Research Council
Funding Amount
$466,980.00
Summary
Approximately 70% of infant death is associated with premature birth. Preterm birth occurs in 6-10% of pregnancies, and there has been no reduction in the rates of premature birth in the last 30 years. This is largely because we remain ignorant of how normal and abnormal birth is controlled. Understanding the physiology of human pregnancy is a critical step in the development of ways to detect and prevent preterm birth. Our group has demonstrated a link between production of a hormone (corticotr ....Approximately 70% of infant death is associated with premature birth. Preterm birth occurs in 6-10% of pregnancies, and there has been no reduction in the rates of premature birth in the last 30 years. This is largely because we remain ignorant of how normal and abnormal birth is controlled. Understanding the physiology of human pregnancy is a critical step in the development of ways to detect and prevent preterm birth. Our group has demonstrated a link between production of a hormone (corticotrophin releasing hormone, CRH) in the placenta and the length of time the baby is carried in the mother. In women who will deliver prematurely a rise in CRH occurs earlier in the pregnancy and more rapidly, while in women who deliver late the rise occurs more slowly. This work has given rise to the concept of a biological clock that determines the length of time the fetus will be carried by the mother before birth, and in which production of CRH in the placenta plays a central role. We have been studying how the CRH gene is controlled in placental cells. We have discovered some regions in the DNA of the CRH gene which have important roles in controlling how much CRH is made by the placenta. The experiments described in this research project will determine the molecular mechanisms that control the production of CRH in the human placenta. This will be done in two ways: (1) by examining the DNA sequences involved in controlling expression of the CRH gene and (2) by identifying the proteins that actually perform the regulating functions that result in either increased or decreased amounts of CRH being produced by the placenta. This important information will help us better understand how normal and abnormal birth is controlled, and from that knowledge new ways to detect and prevent premature birth can be invented.Read moreRead less
Closing The Gap: Early Childhood Sustained Home Visiting For Families Of Aboriginal Infants In An Urban Community
Funder
National Health and Medical Research Council
Funding Amount
$2,244,402.00
Summary
The study aims to determine whether a sustained structured nurse home visiting (SSNVH) program is effective for Aboriginal families. In the context of increased government investment in home visiting programs for Indigenous children, this study will help to answer three critical questions: (1) Does SSNHV result in improved outcomes for Aboriginal infants? (2) Is SSNHV equally effective for Aboriginal and non-Aboriginal infants?(3) What are the issues in adaptation and implementation?
Determinants of children's physical activity and sedentary behaviour: a follow-up study from early childhood. This project investigates changes in preschool children's physical activity and sedentary behaviour, and influences on these changes, during the important period of transition to school. It will provide important information on how we might assist children to be more active, thereby avoiding the detrimental health and social outcomes of inactivity.
The Kids in Communities Study: national investigation of community level effects on children's developmental outcomes. This project (a cross-disciplinary collaboration) will investigate community level factors influencing early childhood developmental outcomes using a mixed methods approach in up to 10 communities across Australia. This will result in a potential set of measures or indicators that reflect communities that are good for children.
Cluster randomised control trial of an early childhood literacy intervention to improve literacy and language outcomes in preschool aged children. Reading failure disproportionately affects disadvantaged communities in Australia, with nearly 40% of poor children failing to read at the minimum reading benchmark in Grade three. Of more concern is the disturbing trend indicating that prior to first grade, socioeconomic status (SES) differences also exist in important antecedents of reading such as ....Cluster randomised control trial of an early childhood literacy intervention to improve literacy and language outcomes in preschool aged children. Reading failure disproportionately affects disadvantaged communities in Australia, with nearly 40% of poor children failing to read at the minimum reading benchmark in Grade three. Of more concern is the disturbing trend indicating that prior to first grade, socioeconomic status (SES) differences also exist in important antecedents of reading such as letter knowledge and phonological processing skills, yet there remains no universal program to promote early language and literacy practices in the primary care setting. We propose a cluster randomised controlled trial to evaluate the efficacy of a multi injection intervention to improve literacy outcomes of children in disadvantaged communities.Read moreRead less
A study investigating the feasibility of implementing a national approach to child and family health services. Understanding and strengthening the way in which universal health services are provided to pregnant women, children and families has the potential to impact over a million Australian families annually. The findings of this study will have national application as federal, state and territory governments work towards implementing a national approach to child and family health services. Th ....A study investigating the feasibility of implementing a national approach to child and family health services. Understanding and strengthening the way in which universal health services are provided to pregnant women, children and families has the potential to impact over a million Australian families annually. The findings of this study will have national application as federal, state and territory governments work towards implementing a national approach to child and family health services. The findings will inform effective multidisciplinary collaboration and service integration, address service gaps and duplication and lead to increased access to services. This study will generate new knowledge about characteristics of organisations, service delivery and professions that facilitate or hinder innovation.Read moreRead less
Promoting healthy eating, active play and sustainability awareness in early childhood curricula: Addressing the Ben10™ problem. A pedagogical communication strategy has been developed to allow early childhood educators to design curriculum interventions that support children’s learning about healthy eating, the importance of active play and the sustainability consequences of their food and toy selections. The aim of this study is to conduct a randomised trial to evaluate the efficacy of the curr ....Promoting healthy eating, active play and sustainability awareness in early childhood curricula: Addressing the Ben10™ problem. A pedagogical communication strategy has been developed to allow early childhood educators to design curriculum interventions that support children’s learning about healthy eating, the importance of active play and the sustainability consequences of their food and toy selections. The aim of this study is to conduct a randomised trial to evaluate the efficacy of the curriculum interventions, developed by teachers using this pedagogical communication strategy, on children’s knowledge about healthy eating, active play and the sustainability consequences of their food and toy selections. This project connects strongly with the learning outcomes of the National Early Years Learning Framework and the Australian Curriculum to be implemented in 2014.Read moreRead less
Investing in the Future of Children in Multicultural Australia - Cultural Competence in Families First (CULCOFAM). Healthy start to life - Discovering how to use valuable parenting knowledge of parents from culturally different backgrounds will help us to draw on them and achieve their childrens' potential (National Agenda for Early Childhood initiative). Preventive healthcare - Knowing how to use cultural resources will help us to promote parenting in culturally appropriate ways, and strengthen ....Investing in the Future of Children in Multicultural Australia - Cultural Competence in Families First (CULCOFAM). Healthy start to life - Discovering how to use valuable parenting knowledge of parents from culturally different backgrounds will help us to draw on them and achieve their childrens' potential (National Agenda for Early Childhood initiative). Preventive healthcare - Knowing how to use cultural resources will help us to promote parenting in culturally appropriate ways, and strengthen capacity for children to grow in best health (Focus on Prevention Initiative). Strengthening Australia's social fabric - The results will help to ensure that child services strengthen local community cohesion, and families can make culturally acceptable choices to better look after their children (National welfare reform and participation agendas). Read moreRead less
The Centre will enhance Australian clinical immunisation research and training, focussing upon clinical questions with translatable outcomes not easily addressed by industry. Optimal immunisation and interventions to maximise uptake of existing and new vaccines in high risk patient groups, such as children with cancer, immigrants, children with chronic diseases and adolescents will be studied. New vaccine trials, innovative use of existing vaccines, systematic collection of vaccine failure data, ....The Centre will enhance Australian clinical immunisation research and training, focussing upon clinical questions with translatable outcomes not easily addressed by industry. Optimal immunisation and interventions to maximise uptake of existing and new vaccines in high risk patient groups, such as children with cancer, immigrants, children with chronic diseases and adolescents will be studied. New vaccine trials, innovative use of existing vaccines, systematic collection of vaccine failure data, and targeted epidemiology and disease modelling vaccine preventable disease will also allow a broad program of research, enabling training and mentoring of young clinical nurse and physician researchers. Collaborations with existing national immunisation, infectious diseases and research institutions will allow maximal effectiveness of clinical studies.Read moreRead less
ARACY/ARC/NHMRC Research Network: Future Generation. Research across a range of disciplines is urgently needed to understand the complexity of pathways contributing to the healthy development of children and young people in modern societies like Australia and to develop effective strategies to improve them. Given our economic prosperity and the level of knowledge about human development, it is profoundly disappointing that many child and youth problems are increasing, creating a crisis in servi ....ARACY/ARC/NHMRC Research Network: Future Generation. Research across a range of disciplines is urgently needed to understand the complexity of pathways contributing to the healthy development of children and young people in modern societies like Australia and to develop effective strategies to improve them. Given our economic prosperity and the level of knowledge about human development, it is profoundly disappointing that many child and youth problems are increasing, creating a crisis in services. This application brings together a highly talented network of researchers to work collaboratively and innovatively with policy makers and those providing services, to enable both new knowledge and implementation of what we already know, to enhance children's futures.Read moreRead less