ARDC Research Link Australia

Funded Activity

Funder: National Health and Medical Research Council
Funding Amount: $451,980.00
Summary: There are approximately 500 million of cases of malaria per year worldwide and about two million deaths per year. Severe malaria including cerebral malaria is a major cause of death. It is caused by the sticking of red blood cells which contain malaria parasites to the lining of microscopic veins and blocking them; what happens after this is complex. The process of sticking is called cytoadherence. We have discovered a gene which is important in this process of sticking. We have called it by the ....
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Funded Activity

Funder: National Health and Medical Research Council
Funding Amount: $483,517.00
Summary: Malaria infection in the placenta impairs the baby's growth, probably by causing placental inflammation. We believe this inflammation interferes with the ability of placental cells to transport nutrients such as amino acids and glucose from mother to baby. We will test this by examining the expression of genes and proteins involved in nutrient transport in placental samples from pregnant women, and in cell lines, and will examine how malaria affects growth factors that control this process.

Funded Activity

Funded Activity

Funded Activity

Funder: National Health and Medical Research Council
Funding Amount: $160,500.00
Summary: Malaria is a serious disease that affects half of the world's population and frequently kills humans after a bout of high fever and coma. Many of those who die are young children who live in areas of the world where health care is very poor. The effectiveness of drugs that we currently have available to prevent or treat malaria is rapidly reducing and there is no vaccine available to prevent people from catching the disease. Our research is important because in order to make better medicines for ....
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Funded Activity

Funder: National Health and Medical Research Council
Funding Amount: $573,055.00
Summary: The greatest impact of Plasmodium falciparum malaria infection in Africa is on children and pregnant women. Malaria infected red blood cells stick to receptor molecules on cells lining blood vessels. The parasite produces a family of proteins called PfEMP1, expressed on the cell surface. These PfEMP1 proteins are responsible for the sticking, and are major targets of the host immune response to malaria. We have found two particular receptor molecules, sugars called chondroitin sulphate A (CSA) a ....
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Funded Activity

Funder: National Health and Medical Research Council
Funding Amount: $112,000.00
Summary: Malaria infection of humans is one of the most important and deadly infectious diseases in the world, killing more than two million people each year. Traditionally, drugs and insecticides have been used to treat the disease and control its spread. Unfortunately, both of these have become much less effective and there now exist untreatable cases of malaria. Alternative control measures are urgently needed and this project focusses on the development of such an alternative, a vaccine against malar ....
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Funded Activity

Funder: National Health and Medical Research Council
Funding Amount: $484,808.00
Summary: The features of severe infection in children living in tropical countries may not allow differentiation between malaria and bacterial-viral causes. This can create significant problems with deciding on appropriate management. In addition, the main complications of malaria such as coma, increased acid levels in the blood and anaemia are not well understood. We plan to characterise infections in Papua New Guinean children in detail and explore mechanisms behind important malarial complications.

Funded Activity

Funder: National Health and Medical Research Council
Funding Amount: $420,872.00
Summary: Malaria is a disease caused by parasites of the genus Plasmodium. It is responsible for more than 2 million deaths per year predominately in Sub-Saharan Africa. Many of the currently used drugs to combat this disease are failing through drug resistance in the parasite population. New and novel drugs are urgently required. This project uses state of the art techniques to identify and validate new and novel targets within the parasite that can be used for rational drug design

Funded Activity

Funder: National Health and Medical Research Council
Funding Amount: $211,527.00
Summary: Worldwide, there are approximately 500 million cases of malaria per year with over 1 million deaths, predominately in children under 5 years of age in Africa. We have identified a region of the malaria parasites' genome that we believe is responsible for two aspects of the parasites life cycle. Firstly, there is a gene responsible for the development of the sexual stage of the parasite that allows transmission from humans to mosquitoes and secondly there are two other genes that allow the parasi ....
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