Aspirin For The Prevention Of Cognitive Decline In The Elderly: A Neuro-Vascular Imaging Study (ENVIS-ion) From ASPREE
Funder
National Health and Medical Research Council
Funding Amount
$1,341,232.00
Summary
The ENVIS-ion trial will examine whether Aspirin is effective in delaying the onset of worsening of thinking and memory abilities in healthy older adults. Magnetic resonance imaging (MRI) of brain structure will detect markers of early worsening of thinking and memory abilities. Blood vessels in the back of the eye (retina) share many features with vessels in the brain. We will compare whether aspirin lessens changes over time of features shown with brain MRI and retinal photography.
The Role Of Intense Physical Activity In Protecting The Ageing Brain
Funder
National Health and Medical Research Council
Funding Amount
$600,079.00
Summary
Previous research supports the notion that physical activity plays a role in maintaining brain health and preventing Alzheimer’s disease. Nevertheless, the type of activity (i.e. intensity of physical activity) that is of greatest benefit to the brain is yet to be established. This project aims to identify the most beneficial exercise intensity, in terms of brain health, measured utilising brain imaging technology.
Antigen Presentation, Recognition And The Immune Response
Funder
National Health and Medical Research Council
Funding Amount
$14,927,045.00
Summary
This program focuses on understanding the development of immunity during infection or inflammatory diseases using a broad array of techniques to dissect the function of various immune cell types and to explore the relationship between structure and function of important cell surface molecules. These studies will improve our ability to design new generation vaccines for combating infectious diseases, controlling cancer, or limiting autoimmune or inflammatory diseases.
Determinant Spreading And The Role Of The MHC Class II Region In Systemic And Organ-specific Autoimmunity
Funder
National Health and Medical Research Council
Funding Amount
$140,570.00
Summary
Autoimmune diseases are among the most important group of disorders affecting the adult population. In these diseases the immune system damages organs and tissues producing widespread pathology (systemic autoimmunity such as Lupus erythematosus) or localised disease (organ-specific autoimmunity such as insulin dependent diabetes). We understand very little about how and why the immune system attacks the body's own tissues. This study examines how antibodies and T lymphocytes are formed against c ....Autoimmune diseases are among the most important group of disorders affecting the adult population. In these diseases the immune system damages organs and tissues producing widespread pathology (systemic autoimmunity such as Lupus erythematosus) or localised disease (organ-specific autoimmunity such as insulin dependent diabetes). We understand very little about how and why the immune system attacks the body's own tissues. This study examines how antibodies and T lymphocytes are formed against components located inside cells of the body. The study involves genetically modifying mice by introducing key human genes which influence the development of autoimmunity. In this way the role of these human genes can be examined experimentally without having to work exclusively on patients. We also hope that these mice might be important in creating new models of celiac disease and insulin dependent diabetes. The proposed experiments should tell us how these genes contribute to the development of autoimmune disease. This understanding could be relevant devising treatments and interventions to prevent autoimmune diseases.Read moreRead less
Antigen Presentation, Recognition And The Immune Response
Funder
National Health and Medical Research Council
Funding Amount
$15,780,848.00
Summary
This program focuses on understanding the development of immune response to viruses and other infectious agents using a broad array of techniques to dissect the function of various immune cell types and to explore the relationship between structure and function of important cell surface molecules. These studies will improve our ability to design new generation vaccines for combating infectious diseases, controlling cancer, or limiting autoimmune diseases like diabetes.
Magnetic Nanostructures for Emerging Technologies: Experimental and Theoretical studies. This project enables collaborations between Australian and European groups in an important and expanding area at the forefront of technology, and facilitates access to state of the art resources in laboratories in Austria and Spain. It carries across knowledge in synchrotron techniques just at the right time, just before the Australian synchrotron goes on line in 2008, allowing time to deepen expertise and t ....Magnetic Nanostructures for Emerging Technologies: Experimental and Theoretical studies. This project enables collaborations between Australian and European groups in an important and expanding area at the forefront of technology, and facilitates access to state of the art resources in laboratories in Austria and Spain. It carries across knowledge in synchrotron techniques just at the right time, just before the Australian synchrotron goes on line in 2008, allowing time to deepen expertise and to obtain specific knowledge. It will help establish a new effort at the University of Western Australia concentrated on developing advanced materials for technology. We will make important contributions to an internationally important area and offer high quality interdisciplinary research training in magnetic nanomaterials science.Read moreRead less
Fast and slow dynamics at coupled magnetic interfaces: Theory and Experiment. Immediate needs for advances in materials for spin electronics and information technology require a deeper physical understanding of new materials in which interfaces and nanometre dimensions determine properties. Interfacial exchange coupling between magnetic layers is a key issue in the formation of many multilayer structures, and several important issues remain unresolved. This is a proposal for a joint theoretical ....Fast and slow dynamics at coupled magnetic interfaces: Theory and Experiment. Immediate needs for advances in materials for spin electronics and information technology require a deeper physical understanding of new materials in which interfaces and nanometre dimensions determine properties. Interfacial exchange coupling between magnetic layers is a key issue in the formation of many multilayer structures, and several important issues remain unresolved. This is a proposal for a joint theoretical and experimental study of technologically important magnetic interfaces by groups at Universities of Florence, Perugia, Leeds and Western Australia.Read moreRead less
Time and frequency resolved magnetometry. Magnetism is well known as a source of fundamental unsolved problems in material physics and condensed matter. It is also an area famous for practical application: the ability to record and read information from magnetic materials is the basis of nearly all mass data storage devices. The aim of this project is to provide first measures of certain key energies and rates associated with magnetic processes. Through a combination of theoretical modelling and ....Time and frequency resolved magnetometry. Magnetism is well known as a source of fundamental unsolved problems in material physics and condensed matter. It is also an area famous for practical application: the ability to record and read information from magnetic materials is the basis of nearly all mass data storage devices. The aim of this project is to provide first measures of certain key energies and rates associated with magnetic processes. Through a combination of theoretical modelling and experiment design, a new experimental technique will be developed into a powerful analysis tool. This work will establish the technique in Australia and create new opportunities for future study.
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Theoretical and experimental studies of exchange bias in thin films. Films containing layers of different types of magnetic materials - in particular, ferromagnetic and antiferromagnetic - have properties which are being exploited in magneto-electronic devices used in recording and manipulation of computer data. These properties are determined by new types of magnetisation processes in the interface between layers. In this project investigations of the magnetic behaviour of interfaces will be ma ....Theoretical and experimental studies of exchange bias in thin films. Films containing layers of different types of magnetic materials - in particular, ferromagnetic and antiferromagnetic - have properties which are being exploited in magneto-electronic devices used in recording and manipulation of computer data. These properties are determined by new types of magnetisation processes in the interface between layers. In this project investigations of the magnetic behaviour of interfaces will be made to provide information of value in the design and optimisation of new and existing devices. The procedures to be developed in this project will be applicable to the understanding of the behaviour of a new range of atomically engineered magnetic structures.Read moreRead less
Spin dependent transport in magnetic nanostructures. The ability to use electron spin in electronic circuits has opened new possibilities for designing devices. A well known example is the giant magnetoresistance, a phenomena discovered over fifteen years ago that now plays a key role in current high density magnetic disc drives. Future developments will involve spin dependent transport through structures wherein quantum interference effects will be important. Two basic problems facing the cons ....Spin dependent transport in magnetic nanostructures. The ability to use electron spin in electronic circuits has opened new possibilities for designing devices. A well known example is the giant magnetoresistance, a phenomena discovered over fifteen years ago that now plays a key role in current high density magnetic disc drives. Future developments will involve spin dependent transport through structures wherein quantum interference effects will be important. Two basic problems facing the construction of a complete theory of transport in such ?mesoscopic? conductors will be solved in this project. The results will provide important insights into the dynamics of spin transport through structures such as magnetic nano-wires.Read moreRead less