Creating Treatment Options For Endometrial Cancer Through High-level Clinical Trials
Funder
National Health and Medical Research Council
Funding Amount
$2,508,156.00
Summary
Endometrial cancer (EC) arises from the inner lining of the womb. Treatment typically involves surgery (hysterectomy) to remove the womb and explore if cancer has affected the lymph glands in the pelvis. The benefit of surgery on the lymph glands is doubtful. My research program will generate evidence to inform clinical practice on the treatment of EC and explore non-surgical treatment alternatives to a hysterectomy for better patient outcomes, particularly in women who wish to start a family.
Decoding tissue-specific components of cereal grain development. This project aims to investigate how barley flowers produce cells that deliver nutrients into developing seeds. This project expects to generate new knowledge through international collaboration and technical improvements in cell biology and genetics, overcoming current methodological limitations to precisely influence seed size, shape and quality, which are traits of agricultural relevance to the Australian cereal industry. Expect ....Decoding tissue-specific components of cereal grain development. This project aims to investigate how barley flowers produce cells that deliver nutrients into developing seeds. This project expects to generate new knowledge through international collaboration and technical improvements in cell biology and genetics, overcoming current methodological limitations to precisely influence seed size, shape and quality, which are traits of agricultural relevance to the Australian cereal industry. Expected outcomes include strengthened international partnerships, leveraged funding and increased knowledge of plant reproduction. This should provide significant benefits, including upskilled researchers, improved research capacity and genetic targets to optimise seed production in challenging climatic conditions. Read moreRead less
Mastering pyrimidine editing in RNA. Many plants and animals can alter their genetic information via RNA (ribonucleic acid) editing, a process that is often essential for the growth and development of the organism. This ability provides accurate control over gene expression and has great potential as a biotechnological tool in agriculture and medicine. RNA editing could be used to switch genes on or off in biotechnological production systems with an unprecedented degree of precision, or to corre ....Mastering pyrimidine editing in RNA. Many plants and animals can alter their genetic information via RNA (ribonucleic acid) editing, a process that is often essential for the growth and development of the organism. This ability provides accurate control over gene expression and has great potential as a biotechnological tool in agriculture and medicine. RNA editing could be used to switch genes on or off in biotechnological production systems with an unprecedented degree of precision, or to correct genetic diseases. This project aims to understand two RNA editing pathways in plants, one of which is found nowhere else and likely to involve a novel enzymatic mechanism. We will use the understanding gained to develop novel RNA processing tools usable in any living organism.Read moreRead less
Protecting cereal grain development at high temperatures. This project aims to investigate new temperature-responsive factors that regulate cereal grain development to protect grain production under heat stress. The new research will leverage international collaborations with access to cutting-edge genetic and technological resources, and refine novel X-ray imaging techniques in Australia, to observe how temperature affects flower structure and function in barley and rice. Favourable mutations t ....Protecting cereal grain development at high temperatures. This project aims to investigate new temperature-responsive factors that regulate cereal grain development to protect grain production under heat stress. The new research will leverage international collaborations with access to cutting-edge genetic and technological resources, and refine novel X-ray imaging techniques in Australia, to observe how temperature affects flower structure and function in barley and rice. Favourable mutations that optimise plant yield and fitness will be defined and explored in other, more complex, cereals such as wheat. Expected outcomes will be fundamental breakthroughs in understanding how plants respond to, and buffer, the effects of heat to lead to translational breeding strategies that bolster grain yield.Read moreRead less
Assess The Feasibility Of Holding The 12th International Conference And Workshop On Lobster Biology And Management In Perth Western Australia In 2020
Funder
Fisheries Research and Development Corporation
Funding Amount
$205,000.00
Summary
The International Conference and Workshop on Lobster Biology began in 1977 when a group of 37 lobster biologists from 6 countries met in Perth, Australia to discuss and compare their work on lobster ecology, physiology, and early stock management protocols, and to find common themes amongst the different species that were commercially fished.
These conferences are held every 3 to 5 years and try to alternate from the northern to southern hemispheres. Participation has risen and held ....The International Conference and Workshop on Lobster Biology began in 1977 when a group of 37 lobster biologists from 6 countries met in Perth, Australia to discuss and compare their work on lobster ecology, physiology, and early stock management protocols, and to find common themes amongst the different species that were commercially fished.
These conferences are held every 3 to 5 years and try to alternate from the northern to southern hemispheres. Participation has risen and held at approximately 200 people from 20 countries. Subsequent ICWLs have been held in Saint Andrews, Canada (1985); La Habana, Cuba (1990); Sanriku, Japan (1993); Queenstown, New Zealand (1997); Key West, Florida USA (2000); Hobart, Australia (2004); Charlottetown, PEI, Canada (2007); Bergen, Norway (2011); and Cancun, Mexico (2014). This year it will be held in Portland, Maine USA (4-9 June 2017).
The tangible impact of these conferences is in the network of international collaborations they spawn and the resulting peer-reviewed publications in the conference proceedings and book chapters. There is synergy in the exchange of ideas and knowledge amongst biologists, managers, fishermen, and dealers from different parts of the world as we face the challenges of a changing environment and a global economy.
The Western Rock Lobster Council and Department of Fisheries, Western Australia (DoF) have stewardship of Australia's largest lobster fishery, the research and management of which is considered to be world class. They see that this may be an important part of their plans for a Lobster CRC.
The 12th ICWL currently does not have a venue and it is due to be held in the southern hemisphere in 2020.
Objectives: 1. Assess the feasibility of convening the 12th International Conference and Workshop on Lobster Biology and Management (ICWL) in Perth Western Australia Read moreRead less
Engineering self-assembled intracellular biological condensates. Cells depend on proteins linking together to build cellular structure, but how weak interactions build stable structure is a mystery. New evidence suggests proteins come together and then change state, employing liquid-like behaviour that builds vital nanoscale structure, such as nuclear bodies called paraspeckles. This project will unlock the secrets of this mysterious behavior of proteins, using paraspeckles as a model. We will u ....Engineering self-assembled intracellular biological condensates. Cells depend on proteins linking together to build cellular structure, but how weak interactions build stable structure is a mystery. New evidence suggests proteins come together and then change state, employing liquid-like behaviour that builds vital nanoscale structure, such as nuclear bodies called paraspeckles. This project will unlock the secrets of this mysterious behavior of proteins, using paraspeckles as a model. We will use this information for nanotechnology application to build a synthetic paraspeckle inspired structure with bespoke function. Benefits will include new concepts in how vital cell structure is assembled and disassembled, and nanotechnology and synthetic biology tools to manipulate cellular processes.Read moreRead less
IDENTIFYING CONTROL ELEMENTS IN CHLOROPLAST GENE EXPRESSION. Energy from sunlight is captured by photosynthesis in plants, providing the basis for the terrestrial food chain. This process takes place in chloroplasts, subcellular structures that derived from photosynthetic bacteria a billion years ago. Chloroplasts have their own DNA, containing genes encoding the most important photosynthetic proteins. This project aims to provide the world’s best resources for the study of chloroplast genes. In ....IDENTIFYING CONTROL ELEMENTS IN CHLOROPLAST GENE EXPRESSION. Energy from sunlight is captured by photosynthesis in plants, providing the basis for the terrestrial food chain. This process takes place in chloroplasts, subcellular structures that derived from photosynthetic bacteria a billion years ago. Chloroplasts have their own DNA, containing genes encoding the most important photosynthetic proteins. This project aims to provide the world’s best resources for the study of chloroplast genes. In the process, we will discover how these important genes are regulated to provide photosynthetic proteins in the right amounts, in the right cells, at the right time. The knowledge and resources gained will facilitate improvement of photosynthetic function in future agricultural crops.Read moreRead less
Evolution and specificity of alternative splicing in plants. This project aims to elucidate fundamental principles of alternative splicing, a basic mechanism that plays a vital role in several biological processes across all organisms. Plants are highly effective in adapting to varied environmental, seasonal and climatic conditions and this project aims to uncover how alternative splicing contributes to regulation of gene expression in response to developmental and environmental cues. Uncovering ....Evolution and specificity of alternative splicing in plants. This project aims to elucidate fundamental principles of alternative splicing, a basic mechanism that plays a vital role in several biological processes across all organisms. Plants are highly effective in adapting to varied environmental, seasonal and climatic conditions and this project aims to uncover how alternative splicing contributes to regulation of gene expression in response to developmental and environmental cues. Uncovering the underlying mechanisms of alternative splicing will not only advance fundamental knowledge, but also has the potential to provide tools and technologies through which sensitivities of plants to environmental stress can be potentially manipulated to benefit agriculture.Read moreRead less
Targeting root architecture to improve plant production in sub-optimal soil. This project aims to identify important missing links in the signalling pathways that connect major plant hormones in their control of root architecture, with a focus on the signalling system that helps plants cope with sub-optimal growing conditions. New discoveries in plant hormones will be applied to crops to provide a deeper understanding of root growth responses under sub-optimal conditions, and to maximise plant e ....Targeting root architecture to improve plant production in sub-optimal soil. This project aims to identify important missing links in the signalling pathways that connect major plant hormones in their control of root architecture, with a focus on the signalling system that helps plants cope with sub-optimal growing conditions. New discoveries in plant hormones will be applied to crops to provide a deeper understanding of root growth responses under sub-optimal conditions, and to maximise plant efficiency. Expected outcomes include a better understanding of signal pathways in roots, improved knowledge about how crops respond to adverse conditions, new knowledge and potential genetic resources for plant industry, and novel ideas about how to improve crop productivity.Read moreRead less