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A Neuro-immune Axis Regulates Beige Adipocyte Development And Function
Funder
National Health and Medical Research Council
Funding Amount
$408,768.00
Summary
Obesity and overweight are modern epidemics that affect two-thirds of Australian adult for which there is no effective therapeutic medicine. Prolonged exposure to cold environment augment energy burning in the body which can potentially suppress weight gain. In this project, I aim to investigate how cold environment induces energy expenditure and identify novel avenue for the treatment of obesity.
Lymph Node Stromal Cells: Phenotype, Function And The Induction Of Tolerance
Funder
National Health and Medical Research Council
Funding Amount
$340,550.00
Summary
Autoimmune diseases, where the immune system kills our own tissue, are initiated in lymph nodes. Lymph node structural cells, called fibroblastic reticular cells (FRC), kill white blood cells capable of reacting against the body's own proteins. FRC could be used to prevent diseases like type I diabetes, but little is understood about their actions. We propose to study the way they work and their potential to prevent or treat autoimmunity when transplanted in mice.