Characterising Lung Growth And Development In Health And Disease
Funder
National Health and Medical Research Council
Funding Amount
$451,716.00
Summary
A/Prof Graham Hall is senior researcher at the Telethon Institute for Child Health Research in Perth, Western Australia and is internationally recognised for his research in the area of respiratory physiology in infants and young children. His research focuses on understanding the impact of respiratory diseases, such as asthma and cystic fibrosis, as well as pre-term birth and air pollution on lung function not only in early life but as the lung grows and develops.
Understanding The Mechanisms Of Nanomedicine Absorption From The Lungs And The Application Of This Knowledge To Improving The Delivery Of Chemotherapeutic Nanomedicines Towards Primary And Secondary Lung Cancers
Funder
National Health and Medical Research Council
Funding Amount
$408,388.00
Summary
The administration of chemotherapeutic 'nanomedicines' via the lungs has the capacity to improve the specific delivery of toxic anti-cancer drugs specifically towards primary and metastatic lung cancers. This project aims to evaluate how nanomedicines are absorbed from the lungs after an inhaled dose, and how they can be best developed as inhaled chemotherapeutics for the treatment of lung cancers.
Regulation Of Lung Stem Cells In Development And Disease
Funder
National Health and Medical Research Council
Funding Amount
$470,143.00
Summary
Breathing air at birth depends on the generation of normal lung structures. Using multiple approaches, we aim to identify factors that control embryonic lung development and adult lung remodeling by stem cells. This will define the molecular events that are critical in normal lung formation that may be altered in lung disorders such as respiratory distress syndrome of prematurity, and will have a significant impact on the future management of lung diseases.
Population Health Modelling, With Applicationsto Asbestos-related Diseases, Cervical Cancer And Prostate Cancer
Funder
National Health and Medical Research Council
Funding Amount
$380,558.00
Summary
Population health modelling can be used to understand complex systems, through bringing together diverse data sources to answer questions of public health importance. We will apply modelling techniques to three public health areas, including: the effects of HPV testing on cervical cancer screening; the impact of the rapid uptake of PSA screening on prostate cancer incidence and mortality; and projections of the incidence of asbestos-related diseases.
Career Development Fellowship_Y C Gary Lee_Translational Research On Malignant Pleural Effusion And Pleural Infection
Funder
National Health and Medical Research Council
Funding Amount
$321,489.00
Summary
My pleural research program uniquely combines a clinical and a lab research arm integrated with a tertiary clinical service. It has a strong track record in improving clinical care in pleural cancer and infection through patient-oriented research. My program has a high productivity and strong commitment to training future pleural researchers. This Fellowship will allow me to continue the upward trajectory in research publication, training of fellows, and making advances that impact patient care.
COPD is a smoking-related airways disease that costs the Australian community over $8.8 billion/yr. It is predicted to become the third most common cause of death in the world by the year 2020 and is linked to an increased risk of lung cancer. There are no effective treatments for COPD. I have been working with a number of anti-inflammatory treatments in a smoking mouse model and will extend my research to see if these treatments can be optimised to treat COPD.
Reducing Perinatal Lung, Heart And Brain Injury In Preterm Infants – From Bench To The Clinic.
Funder
National Health and Medical Research Council
Funding Amount
$463,652.00
Summary
Many infants are exposed to an adverse environment whilst developing in the womb, and are therefore at increased risk of lung, heart and brain injury, with life-long consequences. This research is focused on improving the entry into the world of vulnerable infants, thus reducing the risk and severity of brain injury.