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Indwelling Pleural Catheter For Management Of Cancer-related Pleural Effusions
Funder
National Health and Medical Research Council
Funding Amount
$123,688.00
Summary
Most cancers can be complicated by fluid accumulation (effusion) in the (pleural) cavity between the lung and chest wall, causing significant breathlessness. Indwelling pleural catheter (IPC) is a new method that allows patients to drain the effusion outside the hospital and avoid further invasive interventions. This study aims to provide important information that will help guide use of IPC and manage its complications, especially infection, improve patient outcomes and save healthcare costs.
NY-ESO-1 Expression As An Inducible Chemosensitivity Marker
Funder
National Health and Medical Research Council
Funding Amount
$113,237.00
Summary
Immunotherapy is a new concept treatment for lung cancer. Cancer testis antigen (CTA, eg NY-ESO-1) is an immunogenic molecule that was related with poor outcomes, but our recent studies have found that tumours that express NY-ESO-1 are more responsive to chemotherapy. We are also able to induce expression of NY-ESO-1 in cells that do not normally express it using demethylating agents. We aim to determine if we can increase the response to chemotherapy by using these drugs in combination.
Prospective Clinical Research Of Radiation Response To High-dose Radiotherapy In Lung Tumours And Surrounding Normal Tissue Using Functional Imaging Biomarker Assessments
Funder
National Health and Medical Research Council
Funding Amount
$120,275.00
Summary
Radiotherapy is a potentially curative treatment for cancers of the lung. To improve outcomes, modern research efforts have focussed on radiotherapy dose escalation. However a major limitation to dose escalation is the associated toxicity to the lung. At present, the mechanisms of lung toxicity are incompletely understood. This research will investigate biomarkers of radiation response in patients receiving high-dose radiotherapy to the lung by using state-of-the-art scanning techniques.
Joint Longitudinal And Time-to-event Models For Applications In Health Research
Funder
National Health and Medical Research Council
Funding Amount
$86,073.00
Summary
A recently developed statistical technique ("joint modelling") allows for both repeatedly measured biomarker data (for example, blood pressure measurements) and event time data (for example, time until death) to be analysed together. There are several potential benefits to using these models, but since the methods are relatively new their uptake in applied health research remains limited. This PhD will consist of several distinct but interrelated projects which explore the use of these models.
Lung cancer is the commonest cause of cancer death worldwide. There is growing interest in the genetic causes of lung cancer. The overall aim of this research is to gain a better understanding of the steps in the genetic pathway of lung cancer spread. This knowledge is essential in the development of new targeted therapies and improvement in lung cancer prognosis.
Lung Cancer Screening With Low Dose Computed Tomography (LDCT); Exploring Opportunities To Optimise Disease Prevention Across A Range Of Health Outcomes In Australia.
Funder
National Health and Medical Research Council
Funding Amount
$132,743.00
Summary
Lung cancer is the largest cause of cancer related death in the world. Low dose computed tomography (LDCT) is a scan that reduces deaths from lung cancer by detecting early disease. Australia is investigating a national screening program with LDCT. This project evaluates opportunity provided by such a program to develop a personalised approach to screening using information provided by LDCT beyond cancer (e.g. heart and bone disease) and modify risk factors (e.g. physical activity and smoking).
The Costs And Effectiveness Of New Anticancer Drugs
Funder
National Health and Medical Research Council
Funding Amount
$89,699.00
Summary
The general aim of this project is to assess new anticancer drugs and to determine what contributes to their cost, how well they work and their cost-effectiveness. Specific objectives include to systematically review recent evidence about the costs and cost-effectiveness of anticancer drugs, to perform cost-effectiveness analyses of expensive anticancer treatments based on data from clinical trials and to survey medical oncologists to determine their views on how treatment costs affect decision ....The general aim of this project is to assess new anticancer drugs and to determine what contributes to their cost, how well they work and their cost-effectiveness. Specific objectives include to systematically review recent evidence about the costs and cost-effectiveness of anticancer drugs, to perform cost-effectiveness analyses of expensive anticancer treatments based on data from clinical trials and to survey medical oncologists to determine their views on how treatment costs affect decision making.Read moreRead less
Lung cancer is a leading cause of cancer death globally. Symptoms may not develop until disease is advanced, so it is often incurable at diagnosis. Scientific developments have greatly improved our ability to test for the changes in DNA structure and function responsible for this deadly disease and its progression. This study examines whole lung cancer genomes then uses these findings to develop safer methods for detection based on changes in DNA sequence.
Lung Injury: Influence Of Sodium, Water, Albumin, Gravity And Body Position
Funder
National Health and Medical Research Council
Funding Amount
$117,331.00
Summary
Although patients with poor oxygenation often require mechanical ventilation, only therapies that reduce lung damage improve outcome whereas therapies that improve oxygenation have not been shown to improve outcome. This project will examine the role of two common interventions in critically ill patients, fluid resuscitation and posture change, on lung injury. It is anticipated this will lead to clinical trials that will further improve survival in ventilated patients with respiratory failure.
Micropapillary Adenocarcinoma: The Emergence Of A Discrete Lung Cancer Phenotype And Its Genomic And Transcriptomic Characterization.
Funder
National Health and Medical Research Council
Funding Amount
$117,565.00
Summary
I believe I can describe a new subtype of lung cancer, which has never been classified by the World Health Organization. This has been previously mis-classified or simply ignored. My hypothesis is that this is a distinct disease by virtue of patterns of genetic abnormalities as well as features visible under the microscope. I also believe it is one of the most aggressive cancers and needs new treatments.