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Deciphering How TCR Affinity Regulates CD4 T Cell Help In Immunity And Autoimmunity
Funder
National Health and Medical Research Council
Funding Amount
$850,885.00
Summary
Immune responses require the coordinated interaction and cross-talk between two types of white blood cells known as CD4 and CD8 T cells. A dysregulated interaction between these cells could be the cause of autoimmune and persistent infections by pathogens leading to chronic diseases. The aim of this proposal is to provide a deeper understanding of CD4/CD8 T cell interactions to improve immune outcomes in many chronic diseases in which interaction between these two immune cells is critical.
A Unique Network Of Phagocytic Cells At The Interface Between The Liver And Peritoneal Cavity
Funder
National Health and Medical Research Council
Funding Amount
$787,521.00
Summary
This project aims to characterise the nature and ontogeny of a novel population of cells with phagocytic capacity that forms a network underlying the capsule of mouse and human liver reminiscent of that formed by Langherans cells in the epidermis of the skin. In this project we will characterise this newly described liver capsular macrophage subset, define their ontogeny and assess their specific functions.
Research Fellowship: Immunoregulation And Immunity To Viral Infection
Funder
National Health and Medical Research Council
Funding Amount
$763,845.00
Summary
Award of this fellowship will ensure the continuation of a highly productive research program that over the last 15 years has made numerous seminal contributions to understanding the immune responses generated during viral infection. This multidisciplinary, highly collaborative program seeks to use this knowledge to develop effective therapies, both cellular and gene therapy-based, to treat viral infections and their complications by harnessing the immune system.
Effective Therapies To Treat Viral Infections And Their Complications In Transplantation
Funder
National Health and Medical Research Council
Funding Amount
$1,100,450.00
Summary
Viral infections are a common life threatening complication in transplant recipients, for which there are limited treatment options. We have developed several pre-clinical models that we are using to determine how the treatment of viral infections that occur after transplantation can be improved.
An investigation into the basis of the T-cell mediated adaptive immune response. Understanding the adaptive immune response to human pathogens is critically important to develop strategies to combat infection. This project will provide a better understanding of how T cells combat viral infection, and will lead to fundamental advances in our understanding of viral immunity and the development of novel immunotherapeutic strategies.