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Cardiac Dysfunction In Advanced Liver Disease And After Liver Transplantation
Funder
National Health and Medical Research Council
Funding Amount
$128,224.00
Summary
Heart disease is the leading cause of early death after liver transplantation (LT). The scarcity of donor organs means that LT is a limited and valuable resource. We propose screening for heart disease before LT by CT scanning of heart arteries and heart function on stress testing to improve detection of coronary heart disease (CHD). Follow-up CT scans will also assess if LT causes progression of CHD. These studies will aid in development of personalised treatment strategies to improve outcomes.
High blood pressure and heart disease, are a significant health issue affecting more than 25% of the Australian population. We have recently found that a new enzyme called ACE2 involved in cardiovascular regulation is greatly increased in heart tissue following heart attack. Furthermore, we have evidence that this enzyme is released into the blood after a heart attack or as a consequnce of chronic liver injury. The current project aims to expand on our preliminary data and to understand the basi ....High blood pressure and heart disease, are a significant health issue affecting more than 25% of the Australian population. We have recently found that a new enzyme called ACE2 involved in cardiovascular regulation is greatly increased in heart tissue following heart attack. Furthermore, we have evidence that this enzyme is released into the blood after a heart attack or as a consequnce of chronic liver injury. The current project aims to expand on our preliminary data and to understand the basic biology underlying the mechanism of ACE2 secretion in cardiovascular and liver diseases. In addition, the measurement of ACE2 in plasma may provide useful information on prognosis and knowledge of the mechanism underlying ACE2 secretion may define new therapeutic targets to treat and prevent cardiovascular and liver diseaseRead moreRead less