Osteoporosis is a pathological loss of bone that affects many Australians. It occurs because of an excessive release of calcium from bone that is caused by the overactivity of the cells that break down bone, osteoclasts. We have studied two genes that are involved in the way these cells work and by a close examination of the the way they are regulated we hope to understand how osteoclasts are derived and how their activity is controlled. In particular we will look at two newly dicovered osteocla ....Osteoporosis is a pathological loss of bone that affects many Australians. It occurs because of an excessive release of calcium from bone that is caused by the overactivity of the cells that break down bone, osteoclasts. We have studied two genes that are involved in the way these cells work and by a close examination of the the way they are regulated we hope to understand how osteoclasts are derived and how their activity is controlled. In particular we will look at two newly dicovered osteoclast regulators called PPAR-gamma and PPAR-delta. These offer the opportunity for the development in the future of new, alternative drugs for the treatment of osteoporosis.Read moreRead less
Molecular and genetic analysis of epigenetic components in a model plant. Australia is a major exporter of agricultural food crops thus producers must maintain their competitive advantage in order to compete on the world stage. Food crops unfortunately have large, complex genomes that are not sequenced and a generation time of months that makes research outcomes slow to achieve. This project proposes to utilise a model plant that has a small completely sequenced genome and a short generation tim ....Molecular and genetic analysis of epigenetic components in a model plant. Australia is a major exporter of agricultural food crops thus producers must maintain their competitive advantage in order to compete on the world stage. Food crops unfortunately have large, complex genomes that are not sequenced and a generation time of months that makes research outcomes slow to achieve. This project proposes to utilise a model plant that has a small completely sequenced genome and a short generation time making it ideal to study the fundamental biological process of RNA silencing. Discoveries and outcomes from this project may have the potential to benefit Australian crops, ecosystems and human health.Read moreRead less
The sponge genome project and the evolution of multicellularity: using comparative genomics and developmental biology to reconstruct the first animals. Recently the entire genome from a living fossil - a sponge from the Great Barrier Reef - was sequenced (jointly supported by the ARC and US Department of Energy). As this genome is assembled and analysed, many of the fundamental biological processes that underlie the construction and evolution of all animals, including humans, will be revealed. ....The sponge genome project and the evolution of multicellularity: using comparative genomics and developmental biology to reconstruct the first animals. Recently the entire genome from a living fossil - a sponge from the Great Barrier Reef - was sequenced (jointly supported by the ARC and US Department of Energy). As this genome is assembled and analysed, many of the fundamental biological processes that underlie the construction and evolution of all animals, including humans, will be revealed. In addition, sponge genomics will fuel innovations in medicine and biotechnology. Specifically, sponges are renowned for their capacity to synthesise bioactive compounds used in drug development, and high-grade silica used for semi-conductor construction. This project will identify the gene networks controlling these biosynthetic processes.Read moreRead less
Does developmental noise have an epigenetic basis? One's ultimate phenotype is the result of a combination of genotype and environment, and includes a poorly understood component termed ?developmental noise?. The molecular basis of developmental noise remains unknown, but it appears to be established in early development and to be retained for the life of the organism. We propose that the molecular basis of developmental noise is the epigenetic state of the genome. The stochastic nature of th ....Does developmental noise have an epigenetic basis? One's ultimate phenotype is the result of a combination of genotype and environment, and includes a poorly understood component termed ?developmental noise?. The molecular basis of developmental noise remains unknown, but it appears to be established in early development and to be retained for the life of the organism. We propose that the molecular basis of developmental noise is the epigenetic state of the genome. The stochastic nature of the establishment of epigenetic state, combined with its heritability during mitosis, provides all the essential components for developmental noise. If our hypothesis proves correct, our work will have a major impact on the understanding of one of the most basic concepts in genetics.Read moreRead less
Using genomic information to understand and improve the quality of the Australian South Sea Pearl. Recently, mass-produced freshwater pearls from Asia have markedly increased in quality and begun to compromise our prestigious South Sea Pearl market. This presents Australian pearlers with a challenge to maintain market identity by improving their pearl quality and consistency. By adding genomics to the existing Australian pearl industry armoury we will help not only to maintain the premier positi ....Using genomic information to understand and improve the quality of the Australian South Sea Pearl. Recently, mass-produced freshwater pearls from Asia have markedly increased in quality and begun to compromise our prestigious South Sea Pearl market. This presents Australian pearlers with a challenge to maintain market identity by improving their pearl quality and consistency. By adding genomics to the existing Australian pearl industry armoury we will help not only to maintain the premier position of the Australian South Sea Pearl in the market, but also to move it further ahead. Knowledge of the genetics of pearl formation will advance a range of hatchery and farm practices, such as selective breeding and pearl grafting, which in turn can enhance farm-based operations and the remote communities that support them.Read moreRead less
Enhancing the Pearl: understanding the molecular genetics of pearl lustre, colour and size. Australia produces some of the most valuable pearls in the world. However recently the world has been flooded with high quality mass-produced freshwater pearls. This has begun to eat into our prestigious South Sea Pearl market and now presents Australian pearlers with a challenge to maintain market identity. We propose to respond this challenge by improving the quality and consistency of the cultured Sou ....Enhancing the Pearl: understanding the molecular genetics of pearl lustre, colour and size. Australia produces some of the most valuable pearls in the world. However recently the world has been flooded with high quality mass-produced freshwater pearls. This has begun to eat into our prestigious South Sea Pearl market and now presents Australian pearlers with a challenge to maintain market identity. We propose to respond this challenge by improving the quality and consistency of the cultured South Sea Pearl through gaining a detailed understanding of how the oyster genetically controls pearl biofabrication - focusing on pearl colour, size and lustre. This information will identify pearl oysters that are a source of high-quality donor mantle tissue and that can be used in selective breeding programs.Read moreRead less