Enhancing fertility for the Thoroughbred and Standardbred industries. Enhancing fertility for the Thoroughbred and Standardbred industries. Responding to industry calls for improved methods of detecting and managing infertility in both stallions and mares, this project aims to provide a platform for competitive collaborations between universities, biotechnology companies and horse breeders: the end-users of technological developments in equine reproduction. The Thoroughbred and Standardbred bree ....Enhancing fertility for the Thoroughbred and Standardbred industries. Enhancing fertility for the Thoroughbred and Standardbred industries. Responding to industry calls for improved methods of detecting and managing infertility in both stallions and mares, this project aims to provide a platform for competitive collaborations between universities, biotechnology companies and horse breeders: the end-users of technological developments in equine reproduction. The Thoroughbred and Standardbred breeding industries contribute over $6.5 billion per annum to the Australian economy and employ thousands of staff across their value chains. However, these industries suffer from breeding program inefficiencies that amount to over $800 million in annual losses. Expected outcomes are novel reproductive technologies and specialised research capabilities that will make the Australian equine industry a global leader.Read moreRead less
Enhancing the efficiency of equine reproduction: relevant to the Thoroughbred and Standardbred breeding industries. The purpose of this project is to link the equine breeding industry with a major centre of reproductive research at the University of Newcastle. By creating this unique nexus, major efficiency gains will be achieved for this industry that will not only secure its international competitiveness but also significantly enhance its profitability.
Discovery Early Career Researcher Award - Grant ID: DE180100894
Funder
Australian Research Council
Funding Amount
$365,058.00
Summary
Molecular mechanisms of equine fertility and early recognition of pregnancy. This project aims to identify biomarkers of stallion fertility and early pregnancy in thoroughbred and Standardbred horses using biochemistry, proteomics and ribonucleic acid analyses. Responding to industry calls for improved methods of detecting and managing infertility in both stallions and mares, this project will connect Australian horse breeders and international clinical experts with the world renowned reproducti ....Molecular mechanisms of equine fertility and early recognition of pregnancy. This project aims to identify biomarkers of stallion fertility and early pregnancy in thoroughbred and Standardbred horses using biochemistry, proteomics and ribonucleic acid analyses. Responding to industry calls for improved methods of detecting and managing infertility in both stallions and mares, this project will connect Australian horse breeders and international clinical experts with the world renowned reproductive Priority Research Centre with the intended outcome of novel reproductive technologies and diagnostic tests. This should both secure international competitiveness and significantly enhance profitability and employment in this culturally significant industry.Read moreRead less
Deterioration of structural integrity of ageing ships and marine platforms. Deterioration of structural integrity of ageing ships and marine platforms. This project will research the deterioration of structural integrity and remaining life of marine assets such as ships and offshore energy facilities, by integrating structural response analysis methods with aged-structure assessment techniques. Maritime assets exposed to ocean conditions suffer from time dependent phenomena, which reduce structu ....Deterioration of structural integrity of ageing ships and marine platforms. Deterioration of structural integrity of ageing ships and marine platforms. This project will research the deterioration of structural integrity and remaining life of marine assets such as ships and offshore energy facilities, by integrating structural response analysis methods with aged-structure assessment techniques. Maritime assets exposed to ocean conditions suffer from time dependent phenomena, which reduce structural capability, affect safety and could have catastrophic environmental and economic consequences. Making assets available and affordably safe is a problem for operators. The key to prolonging asset life is in understanding the interrelationships over time between the asset’s structural condition and its use. Anticipated outcomes are superior safety, expected lifetime and economic benefits of maritime assets.Read moreRead less
Ship response under corrosion, fatigue and complex sea-state environments. This project will improve understanding of the gradual deterioration of ships and maritime structures subject to metal corrosion, fatigue and extreme sea-state conditions. Increasingly such understanding is necessary for optimal asset management decisions. These include the potential economic, personnel and other risks involved for ship owners and operators, including the Royal Australian Navy (RAN). The project will use ....Ship response under corrosion, fatigue and complex sea-state environments. This project will improve understanding of the gradual deterioration of ships and maritime structures subject to metal corrosion, fatigue and extreme sea-state conditions. Increasingly such understanding is necessary for optimal asset management decisions. These include the potential economic, personnel and other risks involved for ship owners and operators, including the Royal Australian Navy (RAN). The project will use numerical simulation. It will tackle the Fluid-Structure Interaction problem of ships in waves by integrating Finite Element structural response analysis with cutting-edge Smoothed Particle Hydrodynamics methods. The outcomes will provide new insight into remaining asset life and for exploring optimal maintenance strategiesRead moreRead less
Discovery Early Career Researcher Award - Grant ID: DE120100049
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
New integer programming based theory, formulations and decomposition techniques with applications to integrated problems. Optimisation problems permeate science and industry. By developing new techniques to solve larger and harder problems than is currently possible, more complex questions can be answered, and more accurate solutions obtained. Industries can use such tools to make better financial, resource management, operational, and/or strategic planning decisions.
Liquefaction failures of intermediate soils. The aims of the project are to provide new data on the conditions under which liquefaction failures can occur in soil materials that are intermediate between sand and clay, and to develop models to describe this behaviour. This project addresses two significant problems: liquefaction failures which occur in silty sediments on continental slopes and produce tsunamis, and liquefaction in unsaturated ship cargos with intermediate gradings which lead to s ....Liquefaction failures of intermediate soils. The aims of the project are to provide new data on the conditions under which liquefaction failures can occur in soil materials that are intermediate between sand and clay, and to develop models to describe this behaviour. This project addresses two significant problems: liquefaction failures which occur in silty sediments on continental slopes and produce tsunamis, and liquefaction in unsaturated ship cargos with intermediate gradings which lead to ship losses. The outcomes of the project are expected to be greater understanding of the factors controlling liquefaction in silty materials, a better understanding of the risk of submarine landslides, and models which can be used to predict the conditions under which liquefaction can occur in ship cargos.Read moreRead less
Does developmental noise have an epigenetic basis? One's ultimate phenotype is the result of a combination of genotype and environment, and includes a poorly understood component termed ?developmental noise?. The molecular basis of developmental noise remains unknown, but it appears to be established in early development and to be retained for the life of the organism. We propose that the molecular basis of developmental noise is the epigenetic state of the genome. The stochastic nature of th ....Does developmental noise have an epigenetic basis? One's ultimate phenotype is the result of a combination of genotype and environment, and includes a poorly understood component termed ?developmental noise?. The molecular basis of developmental noise remains unknown, but it appears to be established in early development and to be retained for the life of the organism. We propose that the molecular basis of developmental noise is the epigenetic state of the genome. The stochastic nature of the establishment of epigenetic state, combined with its heritability during mitosis, provides all the essential components for developmental noise. If our hypothesis proves correct, our work will have a major impact on the understanding of one of the most basic concepts in genetics.Read moreRead less
Trade-offs underlying the evolution of female mating strategies. Multiple mating by females (polyandry) is a fundamental problem in behavioural ecology. The project will utilise an Australian species of stingless bee to quantify both the costs and the most probable benefits of polyandry. This will provide insight into the trade-offs underlying the evolution of mating strategies in this species and in general. Stingless bees are important members of many Australian ecosystems and have consider ....Trade-offs underlying the evolution of female mating strategies. Multiple mating by females (polyandry) is a fundamental problem in behavioural ecology. The project will utilise an Australian species of stingless bee to quantify both the costs and the most probable benefits of polyandry. This will provide insight into the trade-offs underlying the evolution of mating strategies in this species and in general. Stingless bees are important members of many Australian ecosystems and have considerable economic potential as well. The knowledge gained during the project will also substantially aid the development and management of the commercial use of stingless bees, which will have both ecological and economic benefits to Australia.Read moreRead less