Sphingosine Kinase: A Target For Obesity-induced Insulin Resistance
Funder
National Health and Medical Research Council
Funding Amount
$626,845.00
Summary
Insulin resistance, a characteristic of type 2 diabetes, is linked to abnormal metabolism of lipid (fat) in tissues such as liver and muscle. This project aims to identify a novel pathway which may promote a build up of lipids in liver and therefore leads to the development of type 2 diabetes. This work may provide a basis for understanding and optimizing treatment of insulin resistance by regulating the control of fat metabolism in liver.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100121
Funder
Australian Research Council
Funding Amount
$1,000,000.00
Summary
An analytical transmission electron microscope for the investigation of functional materials, earth processes and novel condensed matter. Sustainablity depends on the delivery of clean energy, pristine water and air, and the manufacture of consumer products with small environmental footprints. Modelling long-term impacts requires an understanding of the hydro-geological cycles. The technologies are well known—efficient electronics, fuel cells, lightweight composites, and so on—but delivery is ....An analytical transmission electron microscope for the investigation of functional materials, earth processes and novel condensed matter. Sustainablity depends on the delivery of clean energy, pristine water and air, and the manufacture of consumer products with small environmental footprints. Modelling long-term impacts requires an understanding of the hydro-geological cycles. The technologies are well known—efficient electronics, fuel cells, lightweight composites, and so on—but delivery is not straightforward. It is clear, however, that novel materials manipulated at fine scales will be key. Transmission electron microscopy (TEM) guides the development of sustainable technologies. The new TEM facility at ANU will accelerate current studies, by enhancing the materials research portfolio, and extending national and international collaborations in materials, geological and earth sciences.Read moreRead less
Identifying Novel Lipid And Genetic Signatures Of Metabolic Disease In Early Childhood
Funder
National Health and Medical Research Council
Funding Amount
$354,592.00
Summary
Both our genetic makeup and environment can contribute to the development of obesity, diabetes and heart disease. Although onset usually occurs in adulthood, the progression towards disease can start in early life. Early childhood represents an opportunity for intervention to avoid adverse health outcomes in adulthood. This proposal combines two established birth cohorts from Singapore (GUSTO) and Australia (BIS) to examine the genetic and environmental origins of metabolic diseases.
Impact Of Advanced Glycation On Anti-atherogenic Properties Of High Density Lipoprotein
Funder
National Health and Medical Research Council
Funding Amount
$372,471.00
Summary
Type 2 diabetes is a rapidly growing medical problem in Australia and around the world. Diabetes affects human health through its complications and the cardiovascular complications are a cause for major concern. One of the complications is the effect on plasma lipids: it makes cholesterol carrying particles to accumulate in the blood vessels, causing atherosclerosis. We intend to investigate how diabetes modify these particles making them atherogenic.
Experimental mapping of electron densities in nano-structured materials. This project aims to map electrons in nano-structured materials using a new technique combining the latest solid-state theory with electron scattering experiments in one of the world’s most advanced electron microscopes. It is expected that by revealing the electronic structure of nano-scale features in bulk materials for the first time, their functions will become fully explainable. Aside from this new capability, other ....Experimental mapping of electron densities in nano-structured materials. This project aims to map electrons in nano-structured materials using a new technique combining the latest solid-state theory with electron scattering experiments in one of the world’s most advanced electron microscopes. It is expected that by revealing the electronic structure of nano-scale features in bulk materials for the first time, their functions will become fully explainable. Aside from this new capability, other expected outcomes include discovering how heat is converted into electricity in thermoelectric materials and how precipitates affect alloy strength. The benefits may include more informed materials design, more efficient thermoelectrics for sustainable energy technologies, and higher strength-to-weight ratio alloys.Read moreRead less
Precise atomic-scale structure determination in thick nanostructures. This project aims to tackle a great challenge of atomic-scale characterisation: quantitative structure determination. Powerful new electron microscopes offer a window into the atomic world, but complex electron multiple scattering has limited reliable structure determination to ultrathin materials. This project expects to overcome this barrier. Anticipated outcomes include methods that use the latest detector technology to det ....Precise atomic-scale structure determination in thick nanostructures. This project aims to tackle a great challenge of atomic-scale characterisation: quantitative structure determination. Powerful new electron microscopes offer a window into the atomic world, but complex electron multiple scattering has limited reliable structure determination to ultrathin materials. This project expects to overcome this barrier. Anticipated outcomes include methods that use the latest detector technology to determine structure and interatomic bonding in much thicker nanostructures than hitherto possible. This should benefit academic and industrial researchers by giving them new tools to understand and design high-performance materials for applications ranging from catalysis to energy storage to next-generation electronics.Read moreRead less
Novel advances in sub-nanometer imaging. After two decades of research the first wave of applications in nanotechnology and nanobiology is breaking. Immediately key to further progress in both areas is the ability to characterise the structure of such systems and also their evolution on very short time scales. This research project places Australia at the forefront in this endeavour.
Discovery Early Career Researcher Award - Grant ID: DE130100739
Funder
Australian Research Council
Funding Amount
$354,958.00
Summary
Deterministic coherent diffractive imaging for the nanosciences. The technological trend towards nanoscale device fabrication demands picoscale measurements which will only be possible with the development of novel and advanced imaging techniques. This project will develop and implement cutting edge approaches to lensless imaging using both electrons and x-rays and will enable real-time imaging at the picoscale.