The development of new scaffolds for bone repair comprising polycaprolactone and strontium-substituted bioactive glasses. The drive to develop bone grafts to fill major gaps in the skeleton, whilst circumventing the need to use permanent implants has led to a major research thrust towards developing biomaterials for bone-tissue engineering. The project will develop scaffolds with highly osteoconductive bioactive glasses in a polymer matrix for bone regeneration applications.
Smart Matrix™ approaches towards neo vascularisation in bone repair. Bone injuries cost Australia more than $1 billion annually. The development of a medical device combining novel pro-angiogenic technology, Smart Matrix™, with polymer scaffolds for treatment of bone defects by this project, will facilitate rapid development of a blood supply within the defect, aiding bone growth and reducing overall costs compared to current treatments.
A humanised sensory neuron high-throughput screening platform . Sensory neurons are responsible for converting external stimuli such as touch or temperature into graded electrical signals that allow us to interact with the world around us. However, unlike other cell types, sensory neurons cannot proliferate and thus must be removed from human cadavers, or animals, in order to study their pharmacology and function. This limits our ability to understand neuronal signalling pathways. This project a ....A humanised sensory neuron high-throughput screening platform . Sensory neurons are responsible for converting external stimuli such as touch or temperature into graded electrical signals that allow us to interact with the world around us. However, unlike other cell types, sensory neurons cannot proliferate and thus must be removed from human cadavers, or animals, in order to study their pharmacology and function. This limits our ability to understand neuronal signalling pathways. This project aims to use sensory neurons derived from human stem cells to develop and optimise assays that can be used to study the pharmacology and function of human sensory neurons in vitro. This enhances access to critical model systems and technology platforms and removes the need for isolation of cells from cadavers. Read moreRead less
Development of New Generation Magnetic Circular Dichroism Spectrometers. We are building two Magnetic Circular Dichroism (MCD spectrometers) to meet a rising need in the study of metallo-proteins and other molecules of biological interest. The PhD project described in this application will involve instrumentation design, interfacing and sampling handling development for biological samples. We wish to involve a Lastek, a scientific instrumentation company, in the possible commercial development o ....Development of New Generation Magnetic Circular Dichroism Spectrometers. We are building two Magnetic Circular Dichroism (MCD spectrometers) to meet a rising need in the study of metallo-proteins and other molecules of biological interest. The PhD project described in this application will involve instrumentation design, interfacing and sampling handling development for biological samples. We wish to involve a Lastek, a scientific instrumentation company, in the possible commercial development of aspects of this project.Read moreRead less
Redirecting Carbon Flow through Mesophyll and Bundle Sheath Cells of Sugarcane to Produce Poly-3-Hydroxybutyrate. This project is part of the National Priorities "Frontier Technologies for Building and Transforming Australian Industries." Using innovative plant metabolic engineering technologies combined with sophisticated computer modeling we are generating green plants that produce renewable, biodegradable, bioplastics possessing properties such that they are suitable replacements for petrol ....Redirecting Carbon Flow through Mesophyll and Bundle Sheath Cells of Sugarcane to Produce Poly-3-Hydroxybutyrate. This project is part of the National Priorities "Frontier Technologies for Building and Transforming Australian Industries." Using innovative plant metabolic engineering technologies combined with sophisticated computer modeling we are generating green plants that produce renewable, biodegradable, bioplastics possessing properties such that they are suitable replacements for petroleum-derived products in many applications. During the course of these studies, we are increasing our basic level of understanding of plant metabolism of important bioenergy crops. The production of renewable, bioplastics in sugarcane will help to diversify the Australian sugarcane industry by providing a value-added product with significant world-wide markets.Read moreRead less
Red Cell Polymorphisms and Malaria. Certain red blood cell disorders have been associated with innate protection against malaria infection. However many early studies were inconclusive. We intend to carry out a comprehensive study to investigate the effect of red blood cell differences on the invasion and/or growth of Plasmodium falciparum in vitro using improved techniques. Identification of red cell components involved in interaction with P.falciparum would give a better understanding of host ....Red Cell Polymorphisms and Malaria. Certain red blood cell disorders have been associated with innate protection against malaria infection. However many early studies were inconclusive. We intend to carry out a comprehensive study to investigate the effect of red blood cell differences on the invasion and/or growth of Plasmodium falciparum in vitro using improved techniques. Identification of red cell components involved in interaction with P.falciparum would give a better understanding of host parasite interactions which may in turn suggest novel approaches or pathways to persue. This may eventually lead to the development of novel therapeutics.
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A lipodomic approach to cnidarian-dinoflagellate symbiosis. Fatty Acids are essential for human health and for reef health. This lipodomic study using newly developed techniques, aims to understand the essential and non-essential fatty acid metabolic exchange in the symbiosis that drives coral reef formation and health, and in turn gives reflective insight into our own metabolism.
Bone tissue engineering using innovative tubular dual-layered nanofiber meshes. Lifetime risks for long-bone fractures in Caucasians over the age of 50 are 17 per cent for women and 6 per cent for men. A clear therapeutic need exists to address the ever-increasing problems of diminished productivity and reduced quality of life associated with bone disorders as the population ages. To address this challenge, the project’s multidisciplinary, international team will develop technologies to heal tib ....Bone tissue engineering using innovative tubular dual-layered nanofiber meshes. Lifetime risks for long-bone fractures in Caucasians over the age of 50 are 17 per cent for women and 6 per cent for men. A clear therapeutic need exists to address the ever-increasing problems of diminished productivity and reduced quality of life associated with bone disorders as the population ages. To address this challenge, the project’s multidisciplinary, international team will develop technologies to heal tibial defects. Furthermore, it will establish Australia's prominence in the tissue engineering field, training the next generation of young scientists and engineers. This technology will be of interest to numerous research groups and companies worldwide and will foster international collaboration, placing Australia at the forefront of this emerging field.Read moreRead less
Intelligent scaffolds and methods for repair of osteochondral defects. Osteoarthritis (OA) produces articulation of bone against bone resulting in extreme pain and disability. Of all musculoskeletal disorders, osteoarthritis has the greatest social and economic implications worldwide. By 2030, it is projected that 9.3% of the adult population will suffer from arthritis, significantly affecting their quality of life and overall productivity. A tissue engineered product capable of repairing osteoc ....Intelligent scaffolds and methods for repair of osteochondral defects. Osteoarthritis (OA) produces articulation of bone against bone resulting in extreme pain and disability. Of all musculoskeletal disorders, osteoarthritis has the greatest social and economic implications worldwide. By 2030, it is projected that 9.3% of the adult population will suffer from arthritis, significantly affecting their quality of life and overall productivity. A tissue engineered product capable of repairing osteochondral defects that does not require revision over time but becomes fully integrated with the host tissue will have significant benefits. It will improve patient activity and quality of life, and significantly reduce current health care costs associated with osteoarthritis sufferers.Read moreRead less
Structural studies on carbohydrate modifying enzymes. Carbohydrates form one of four major classes of biological macromolecules, and are major targets for drug design. We have developed methods for the production of carbohydrate synthesising enzymes and will determine the structures of these enzymes to provide the foundation for structure based design of inhibitors. The research will allow us to understand how these enzymes function in normal circumstances and how they malfunction in disease sta ....Structural studies on carbohydrate modifying enzymes. Carbohydrates form one of four major classes of biological macromolecules, and are major targets for drug design. We have developed methods for the production of carbohydrate synthesising enzymes and will determine the structures of these enzymes to provide the foundation for structure based design of inhibitors. The research will allow us to understand how these enzymes function in normal circumstances and how they malfunction in disease states such as cancer. The long-term outcome will be a significantly enhanced body of knowledge of this poorly understood group of enzymes and the development of new carbohydrate based chemicals with novel therapeutic applications.Read moreRead less