A Randomised Phase III Study Of Radiation Doses And Fractionation Schedules For Non-low Risk Ductal Carcinoma In Situ Of The Breast
Funder
National Health and Medical Research Council
Funding Amount
$658,419.00
Summary
After surgery to remove ductal carcinoma in situ (DCIS), a pre-invasive form of breast cancer, radiotherapy to the breast decreases the risk of recurrence. The study investigates if a higher radiation dose to the tumour bed improves tumour control, and if a shorter course of radiotherapy is as effective as the standard longer course. It also assesses quality of life consequences of treatment and tests biomarkers that may predict the risk of recurrence in individual patients.
Assessment Of Rectal And Urinary Toxicity From The RADAR Prostate Radiotherapy Trial – Dosimetric Constraints For Novel Symptom Clustering, Derivation Of Radiobiological Parameters And Assessment Of Patient Localisation Effects
Funder
National Health and Medical Research Council
Funding Amount
$323,484.00
Summary
Increasing prostate radiotherapy cure rates by increasing radiation dose is limited by side-effects in the rectum and bladder which can greatly decrease patient quality of life. This study will utilise detailed data, collected during a large Australasian trial, to extract information on how patterns of dose delivery influence side-effects in the bladder and rectum, including a novel definition of rectal toxicity. The result will be more effective future treatment.
A Randomized Trial Of 2 Radiation And Systemic Therapy Strategies In Good Prognosis Advanced Human Papilloma Virus -associated Cancer Of The Tonsil And Base Of Tongue
Funder
National Health and Medical Research Council
Funding Amount
$1,097,932.00
Summary
Cancers of the tonsil and base of tongue due to the human papilloma virus have a better prognosis than other head and neck cancers, but standard treatment can result in significant acute and late side effects. This trial aims to compare two types of chemotherapy and radiotherapy that are less intensive than standard treatment. The aim of the trial is to determine which treatment is associated with better quality of life and less side effects, while maintaining efficacy.