Roles For MAPK-ERK1-2, -catenin-TCF And Smad3 Mediated Signalling Pathways In TGF -induced Cataract
Funder
National Health and Medical Research Council
Funding Amount
$339,071.00
Summary
Posterior capsular opacification (PCO) is a common and costly complication of cataract surgery that is caused by aberrant growth of lens cells. The TGF growth factor family causes PCO. TGF activates three signalling pathways in the lens, MAPK-ERK1-2, -catenin-TCF and Smad3; however currently we do not know which one induces PCO. This project will identify the pathway(s) that prevent TGF from causing cataracts. This is critical for the development of pharmaceuticals to prevent PCO.
Preventing Blindness: Blocking TGF¤-induced EMT And Cataract Development
Funder
National Health and Medical Research Council
Funding Amount
$343,824.00
Summary
Cataract, the loss of transparency of the eye lens, is a major cause of blindness. We have identified molecules in the lens important for maintenance of its transparency and plan to characterise their effectiveness in preventing cataract formation.