Neural correlates of performance trade-offs and interference in dual-task performance. Our daily lives are characterised by our ability to produce and sustain a wide range of different movement patterns and to deliberately change patterns as the situation demands. In this project we seek to understand the relationship between brain processes, attentional demands, and the control and learning of coordinated behaviour. A further aim will be to examine how this relationship may be altered as a re ....Neural correlates of performance trade-offs and interference in dual-task performance. Our daily lives are characterised by our ability to produce and sustain a wide range of different movement patterns and to deliberately change patterns as the situation demands. In this project we seek to understand the relationship between brain processes, attentional demands, and the control and learning of coordinated behaviour. A further aim will be to examine how this relationship may be altered as a result of aging, degenerative disease, or brain damage. This research will provide a foundation upon which rehabilitation strategies can be developed for the movement impaired.Read moreRead less
Intracortical inhibition evaluated by paired-pulse TMS during choice and simple reaction time tasks. The research will investigate the neurophysiological processes responsible for the selection and initiation of movement in response to an external stimulus. Slowness in the initiation and execution of movement is a common feature of 'neurological aging', neurodegenerative disease, and brain injury. Understanding the brain mechanisms involved in response selection and movement initiation will pro ....Intracortical inhibition evaluated by paired-pulse TMS during choice and simple reaction time tasks. The research will investigate the neurophysiological processes responsible for the selection and initiation of movement in response to an external stimulus. Slowness in the initiation and execution of movement is a common feature of 'neurological aging', neurodegenerative disease, and brain injury. Understanding the brain mechanisms involved in response selection and movement initiation will provide information for the development of specific intervention techniques to improve motor function in these groups.Read moreRead less
Facilitatory and inhibitory mechanisms during interlimb coordination in young and older adults. The project seeks to understand how people coordinate their limbs and the factors which limit and enhance this capacity. This is of critical importance because coordination is a dominant deficit in aging and in patients suffering brain insult and neurodegenerative diseases. Disruption of this capacity compromises individual work productivity, mobility and independence. Proficient motor functioning is ....Facilitatory and inhibitory mechanisms during interlimb coordination in young and older adults. The project seeks to understand how people coordinate their limbs and the factors which limit and enhance this capacity. This is of critical importance because coordination is a dominant deficit in aging and in patients suffering brain insult and neurodegenerative diseases. Disruption of this capacity compromises individual work productivity, mobility and independence. Proficient motor functioning is an important lifestyle factor as humans age and deficits in coordinated muscle activity will increase the risk of falls which are the leading cause of injury in elderly adults. Identification of changes in brain processes involved in interlimb coordination will allow for the development of strategies to improve motor functions in the aged.Read moreRead less
Interlimb coordination dynamics in stroke. Everyday we use our limbs in a coordinated manner. However, for a person who has suffered a stroke resulting in weakness on one side of the body even the simplest interlimb coordination tasks are difficult to perform. This project will examine interlimb coordination in persons who have suffered a stroke and explore whether the coupling between limbs can be exploited to promote fuctional recovery of an impaired limb. In particular, the research seeks to ....Interlimb coordination dynamics in stroke. Everyday we use our limbs in a coordinated manner. However, for a person who has suffered a stroke resulting in weakness on one side of the body even the simplest interlimb coordination tasks are difficult to perform. This project will examine interlimb coordination in persons who have suffered a stroke and explore whether the coupling between limbs can be exploited to promote fuctional recovery of an impaired limb. In particular, the research seeks to identify the critical components underlying the effectiveness of an intervention involving the pratice of actions bilaterally and simultaneously.Read moreRead less
An investigation of limb dynamics as a constraint on human motor learning. Everyday we use our limbs to interact with a variety of objects. These objects have various mechanical characteristics (dynamics), which require the human motor system to provide appropriate control. This project seeks to understand how the brain, in both normal and disease states, learns new limb dynamics as we interact with a novel mechanical environmental. Repetitive brain stimulation will be used to selectively block ....An investigation of limb dynamics as a constraint on human motor learning. Everyday we use our limbs to interact with a variety of objects. These objects have various mechanical characteristics (dynamics), which require the human motor system to provide appropriate control. This project seeks to understand how the brain, in both normal and disease states, learns new limb dynamics as we interact with a novel mechanical environmental. Repetitive brain stimulation will be used to selectively block the contribution of various cortical regions during the learning of a new motor skill and later, the recall of that skill. This will allow us to determine definitively which areas are critical to motor skill acquisition.Read moreRead less
A longitudinal study of neuropsychological and neuromotor effects of low level manganese exposure. This study will investigate the neuropsychological and neuromotor effects of low level exposure to mangenese particulate. Previous studies have indicated symptomology of high level exposure, but there is contention in the literature regarding the effects of low levels of exposure. Our aim is to refine measures of cumulative exposure and develop a more comprehensive and senstitive testing protocol t ....A longitudinal study of neuropsychological and neuromotor effects of low level manganese exposure. This study will investigate the neuropsychological and neuromotor effects of low level exposure to mangenese particulate. Previous studies have indicated symptomology of high level exposure, but there is contention in the literature regarding the effects of low levels of exposure. Our aim is to refine measures of cumulative exposure and develop a more comprehensive and senstitive testing protocol than has been reported thus far. These measures and protocols will be incorporated into a longitudinal design, which has not been conducted in research studies to date. In addition, a database of exposure variables will be developed to facilitate long-term, accurate research into the effects of the low levels of exposure.Read moreRead less
Preparatory processes in rapid interceptive action. This project investigates the nature of the processes involved in preparing to act in response to a moving object: actions that elite sportspeople perform with amazing precision: timing to within a few thousandths of a second is routine when hitting a ball in tennis and cricket. The average person can be capable of something similar and it means being ready to make the right movement at the right time. Understanding the preparatory processes in ....Preparatory processes in rapid interceptive action. This project investigates the nature of the processes involved in preparing to act in response to a moving object: actions that elite sportspeople perform with amazing precision: timing to within a few thousandths of a second is routine when hitting a ball in tennis and cricket. The average person can be capable of something similar and it means being ready to make the right movement at the right time. Understanding the preparatory processes involved will be a significant scientific advance and knowledge of their workings and limits can contribute to the development of strategies for improving safety in dynamic environments such as city roads. This project will put an Australian laboratory at the cutting edge in this area of research.Read moreRead less
Determining the neural mechanisms of visual stimuli and motor responses. This project aims to determine how we select actions to visual cues rapidly, unconsciously and automatically. Learning associations between visual stimuli and motor responses is part of normal development and continues throughout life. Rapid deployment of these actions is often critical for safety yet we have limited knowledge of how the human brain does this. This project will use neuroimaging tools to characterise the spa ....Determining the neural mechanisms of visual stimuli and motor responses. This project aims to determine how we select actions to visual cues rapidly, unconsciously and automatically. Learning associations between visual stimuli and motor responses is part of normal development and continues throughout life. Rapid deployment of these actions is often critical for safety yet we have limited knowledge of how the human brain does this. This project will use neuroimaging tools to characterise the spatial and temporal neural architecture underlying these processes and determine how the dorsal and ventral streams of visual processing, specialised for motor control and recognition respectively, interact in vision-based actions as these actions become learned.Outcomes will provide new frameworks for driving improvement in any domain in which goal-directed actions depend on the rapid processing of visual information, including human-machine interfaces for defence, economic development, education, health, science and technology.Read moreRead less
Motor control of the upper airway muscle genioglossus. This project aims to evaluate a recent proposal about the motor control of the upper airway muscle Genioglossus. The upper airway muscles, the most complex in the human body, are critical for breathing and speaking, but are not well understood. Genioglossus draws the base of the tongue forward to maintain airway patency. This project will study genioglossus during wakefulness and sleep in normal healthy individuals. It is anticipated that th ....Motor control of the upper airway muscle genioglossus. This project aims to evaluate a recent proposal about the motor control of the upper airway muscle Genioglossus. The upper airway muscles, the most complex in the human body, are critical for breathing and speaking, but are not well understood. Genioglossus draws the base of the tongue forward to maintain airway patency. This project will study genioglossus during wakefulness and sleep in normal healthy individuals. It is anticipated that the project will suggest improved avenues for treatment of sleep related respiratory disorders.Read moreRead less
Understanding the physiological changes accompanying arousal from sleep. This project aims to investigate neural memory in upper airway dilator muscles. Following brief awakening from sleep (arousal), upper airway dilator muscle activity is elevated for 20–30 seconds despite inhibitory stimuli being present. The cause for the elevated activity is unknown. This project aims to investigate whether a form of neural memory contributes to the elevated activity. It expects to demonstrate that arousal ....Understanding the physiological changes accompanying arousal from sleep. This project aims to investigate neural memory in upper airway dilator muscles. Following brief awakening from sleep (arousal), upper airway dilator muscle activity is elevated for 20–30 seconds despite inhibitory stimuli being present. The cause for the elevated activity is unknown. This project aims to investigate whether a form of neural memory contributes to the elevated activity. It expects to demonstrate that arousal can induce a neural memory that is not inhibited by usual stimuli. The findings are expected to increase our understanding of normal human functioning but may also have implications for conditions where upper airway muscles are important such as dysphagia, sleep apnea and numerous other sleep disorders.Read moreRead less