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Linkage Infrastructure, Equipment And Facilities - Grant ID: LE210100110
Funder
Australian Research Council
Funding Amount
$474,000.00
Summary
High Resolution Mass Spectrometer for Chemical Characterisation in WA. The aim of this proposal is to establish new high resolution mass spectrometry facilities for Western Australia which will support multiple areas of chemical, materials and environmental science. The proposed platform will address a major need for the separation and characterisation of molecules relevant to synthetic and natural products chemistry, advanced materials and environmental analyses. The facility will support a num ....High Resolution Mass Spectrometer for Chemical Characterisation in WA. The aim of this proposal is to establish new high resolution mass spectrometry facilities for Western Australia which will support multiple areas of chemical, materials and environmental science. The proposed platform will address a major need for the separation and characterisation of molecules relevant to synthetic and natural products chemistry, advanced materials and environmental analyses. The facility will support a number of high impact ARC funded research projects in diverse areas, such as plant growth regulation, molecular electronics and environmental contaminants. The new instrumentation will be easy to use, provide advanced high quality data and overall benefit the next generation of researchers in Western Australia.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE150100517
Funder
Australian Research Council
Funding Amount
$360,000.00
Summary
Organocatalysis: A New Horizon for Synthesis of Organic Structures. The current technologies to synthesise organic substances, an important part of human life, often involve the use of excess amounts of reagents or precious and toxic metal catalysts, which incur high production costs and severe environmental impact. This project aims to use organocatalysis, chemical processes catalysed by stable, small, easily accessible, non-metallic organic compounds, to find a solution for these issues. Novel ....Organocatalysis: A New Horizon for Synthesis of Organic Structures. The current technologies to synthesise organic substances, an important part of human life, often involve the use of excess amounts of reagents or precious and toxic metal catalysts, which incur high production costs and severe environmental impact. This project aims to use organocatalysis, chemical processes catalysed by stable, small, easily accessible, non-metallic organic compounds, to find a solution for these issues. Novel organocatalytic methods will be designed and developed in order to promote environmentally friendly, highly efficient and selective chemical procedures for low cost production of laboratory organic substances and application in the industrial synthesis of potential agrochemicals and medicinal agents.Read moreRead less
Confinement of space based on association of water soluble container molecules. The proposed research addresses the use of water soluble bowl shaped molecules or ions (cavitands) in conjunction with metal ions and crown ether and related cryptand molecules to form molecular capsules, two or more of the components being pre-programmed to assemble thus. The new materials will be unique in supramolecular chemistry, with the associated architectures bearing on materials science, molecular electronic ....Confinement of space based on association of water soluble container molecules. The proposed research addresses the use of water soluble bowl shaped molecules or ions (cavitands) in conjunction with metal ions and crown ether and related cryptand molecules to form molecular capsules, two or more of the components being pre-programmed to assemble thus. The new materials will be unique in supramolecular chemistry, with the associated architectures bearing on materials science, molecular electronics, separation sciences, and drug delivery. The new range of water soluble container molecules that will become accessible as part of this proposal, promises new applications in these areas.Read moreRead less
New Chiral Metal Catalysts; Going Beyond the State of the Art. The synthesis of both natural and unnatural organic compounds in optically active form is a central challenge in chemistry. Because the most important molecules in nature are chiral and of specific handedness, there exists a growing need to access any given organic compound in its optically pure form. Asymmetric catalysis offers the most elegant way to solving this problem and this project will target some of the difficult challenges ....New Chiral Metal Catalysts; Going Beyond the State of the Art. The synthesis of both natural and unnatural organic compounds in optically active form is a central challenge in chemistry. Because the most important molecules in nature are chiral and of specific handedness, there exists a growing need to access any given organic compound in its optically pure form. Asymmetric catalysis offers the most elegant way to solving this problem and this project will target some of the difficult challenges in realising asymmetric synthesis, building new, privileged chiral ligands, opening new catalytic pathways for constructing chiral compounds and understanding the intimate catalytic pathway that enables reactivity and selectivity. This will generate applications across the chemical industries.Read moreRead less
Design and synthesis of novel lanthanoid complexes for the fabrication of light emitting devices. There is a huge and still growing economy centred around the design and fabrication of low-cost Light Emitting Devices (LEDs), as demonstrated by the excess of US$1.3 billion invested in this field between 2000 and 2007. Nations focused on the production of new and more efficient materials will be at the forefront of these emerging technologies. The major thrust of this proposal, the design and prep ....Design and synthesis of novel lanthanoid complexes for the fabrication of light emitting devices. There is a huge and still growing economy centred around the design and fabrication of low-cost Light Emitting Devices (LEDs), as demonstrated by the excess of US$1.3 billion invested in this field between 2000 and 2007. Nations focused on the production of new and more efficient materials will be at the forefront of these emerging technologies. The major thrust of this proposal, the design and preparation of luminescent rare earths complexes, and their use for the fabrication of LEDS, represent a good opportunity for Australia to access this growing market. Read moreRead less
A terrestrial hot spring setting for the origin of life. This project aims to test the proposal that a terrestrial hot spring field could have been the setting for the origin of life, in preference over the currently favoured site at deep sea vents. The project will involve an integrated, and multi-disciplinary study of the rocks, fluids, and molecules that together make up ancient to modern hot spring systems, and experiments on prebiotic organic chemistry using early Earth materials. Results w ....A terrestrial hot spring setting for the origin of life. This project aims to test the proposal that a terrestrial hot spring field could have been the setting for the origin of life, in preference over the currently favoured site at deep sea vents. The project will involve an integrated, and multi-disciplinary study of the rocks, fluids, and molecules that together make up ancient to modern hot spring systems, and experiments on prebiotic organic chemistry using early Earth materials. Results will be used to develop a terrestrial origin of life setting and assist in the search for life on Mars.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE160100482
Funder
Australian Research Council
Funding Amount
$364,536.00
Summary
Indoleamides as Molecular Interventions for Tuberculosis. This project aims to develop chemical probes capable of inhibiting the transport of essential mycolic acid across the cell wall of Mycobacterium tuberculosis. The emergence of resistant strains of Mycobacterium tuberculosis necessitates the identification of new, validated biological target(s) in the current control of tuberculosis. Preliminary data in this proposal demonstrate the discovery of indoleamides as a novel chemical entity. Dev ....Indoleamides as Molecular Interventions for Tuberculosis. This project aims to develop chemical probes capable of inhibiting the transport of essential mycolic acid across the cell wall of Mycobacterium tuberculosis. The emergence of resistant strains of Mycobacterium tuberculosis necessitates the identification of new, validated biological target(s) in the current control of tuberculosis. Preliminary data in this proposal demonstrate the discovery of indoleamides as a novel chemical entity. Development of these indoleamides may provide insights into a novel mechanism of action that could be targeted in combination with existing antitubercular agents.Read moreRead less
ARC Centre of Excellence for Innovations in Peptide and Protein Science. The ARC Centre of Excellence for Innovations in Peptide and Protein Science (CIPPS) strives to build a critical understanding of peptides and proteins in order to unleash the potential of these biomolecules for human benefit. We will discover nature’s untapped reservoir of peptides and proteins, decode their structures and functions, and
develop enhanced synthetic technologies to address biology’s next grand challenge—the d ....ARC Centre of Excellence for Innovations in Peptide and Protein Science. The ARC Centre of Excellence for Innovations in Peptide and Protein Science (CIPPS) strives to build a critical understanding of peptides and proteins in order to unleash the potential of these biomolecules for human benefit. We will discover nature’s untapped reservoir of peptides and proteins, decode their structures and functions, and
develop enhanced synthetic technologies to address biology’s next grand challenge—the design of peptides and proteins for targeted scientific, agricultural, biotechnology, animal health and pharmaceutical applications. CIPPS will assemble leading researchers from diverse disciplines to create a sustainable national entity that will drive new Australian industries and train next generation researchers.Read moreRead less