Synchrotron X-ray Assessment Of Airway Surface Physiology For Cystic Fibrosis
Funder
National Health and Medical Research Council
Funding Amount
$778,228.00
Summary
We seek a cure or long-lasting therapy for the fatal airway disease in cystic fibrosis. Disease is caused by a shallow and dehydrated airway surface liquid (ASL), allowing bacteria to infect the lung. We can introduce a corrective gene into mouse airways where it can be effective for over 1 yr, but no fast, accurate and non-invasive measurement exists to test if treatments are successful. We will develop methods using synchrotron light to directly measure ASL depth changes in live mouse airways.
Dehumidification and cooling driven by solar/waste heat using liquid desiccants. The provision of comfort cooling is responsible for a considerable and increasing portion of the world energy demand and electricity peak demand. To substitute electrically driven vapour compression machines with their high electrical energy consumption and especially high peak loads, the use of solar energy or waste heat for a cooling and dehumidification system driven by liquid desiccants is a promising opportunit ....Dehumidification and cooling driven by solar/waste heat using liquid desiccants. The provision of comfort cooling is responsible for a considerable and increasing portion of the world energy demand and electricity peak demand. To substitute electrically driven vapour compression machines with their high electrical energy consumption and especially high peak loads, the use of solar energy or waste heat for a cooling and dehumidification system driven by liquid desiccants is a promising opportunity. The project utilises the complementary strengths in the research groups to develop practical and economically feasible cooling/dehumidification systems for different types of buildings with different moisture removal and cooling requirements at different locations (Australia, Southern Europe).Read moreRead less
A theoretical investigation into the effect of nonlinear wave interactions in promoting transition-to-turbulence. The problem of transition-to-turbulence remains one of the fundamental unanswered questions in fluid dynamics. An understanding of the processes leading to transition is necessary if the active control of turbulence is to be achieved. This project will focus attention on a new class of waves, which have only recently been described the CI, in order to determine how they are triggered ....A theoretical investigation into the effect of nonlinear wave interactions in promoting transition-to-turbulence. The problem of transition-to-turbulence remains one of the fundamental unanswered questions in fluid dynamics. An understanding of the processes leading to transition is necessary if the active control of turbulence is to be achieved. This project will focus attention on a new class of waves, which have only recently been described the CI, in order to determine how they are triggered and how they may serve to actively promote the early development of turbulence in a broad class of fluid flows.Read moreRead less
The effect of diffusive mass transfer on interfacial fluid instabilities. A wide variety of industrial and physiological fluid flows fall into the general class of two-layer fluids wherein a fluid of one density/viscosity flows over another of a different density/viscosity. Such flows can ultimately become turbulent (that is, chaotic) through the growth of small background disturbances. An understanding of this process is important in controlling fluid dynamical mixing. This project will conside ....The effect of diffusive mass transfer on interfacial fluid instabilities. A wide variety of industrial and physiological fluid flows fall into the general class of two-layer fluids wherein a fluid of one density/viscosity flows over another of a different density/viscosity. Such flows can ultimately become turbulent (that is, chaotic) through the growth of small background disturbances. An understanding of this process is important in controlling fluid dynamical mixing. This project will consider two layer flows in the case when diffusive mass transfer acts at the fluid interface with the aim of determining how diffusion affects the process of transition-to-turbulence.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0238345
Funder
Australian Research Council
Funding Amount
$373,000.00
Summary
Advanced Laser Diagnostics in Dilute Heterogeneous Combustion. This proposal seeks to establish a state-of-the-art laser diagnostics facility with unique capabilities for non-intrusive measurements in dilute multi-phase flows. Such heterogeneous flows which involve stationary surfaces, disperse suspended droplets or suspended particles are found in many applications including engines, furnaces, industrial and chemical processing and micro-combustion devices. This facility will give Australian re ....Advanced Laser Diagnostics in Dilute Heterogeneous Combustion. This proposal seeks to establish a state-of-the-art laser diagnostics facility with unique capabilities for non-intrusive measurements in dilute multi-phase flows. Such heterogeneous flows which involve stationary surfaces, disperse suspended droplets or suspended particles are found in many applications including engines, furnaces, industrial and chemical processing and micro-combustion devices. This facility will give Australian researchers the unprecedented opportunity to perform measurements of flow, mixing, temperature and composition fields in the gas and liquid or solid phases simultaneously. The resulting data will advance current knowledge in these complex flows and lead to new and improved reactor designs.
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The Role Of UPF3B And Nonsense Mediated MRNA Decay Surveillance In The Pathology Of Intellectual Disability.
Funder
National Health and Medical Research Council
Funding Amount
$789,954.00
Summary
Proper functioning of the nonsense mediated mRNA decay (NMD or 'mRNA police') is crucial for any cell to ensure normal development and function. When NMD is compromised the outcome is learning and memory problems, autism or schizophrenia. Under this project we study malfunctioning NMD using stem and neuronal cells derived from patients' skin cells. Some of the affected genes might be considered for therapeutic interventions. NMD is relevant to 1000s of human disorders and as such it is of fundam ....Proper functioning of the nonsense mediated mRNA decay (NMD or 'mRNA police') is crucial for any cell to ensure normal development and function. When NMD is compromised the outcome is learning and memory problems, autism or schizophrenia. Under this project we study malfunctioning NMD using stem and neuronal cells derived from patients' skin cells. Some of the affected genes might be considered for therapeutic interventions. NMD is relevant to 1000s of human disorders and as such it is of fundamental importance.Read moreRead less
About one in eight known genetic disorders involve DNA alteration that activates a cellular quality control mechanism that disables the affected gene. This mechanism is more efficient in some individuals than others. It can influence disease outcomes and severity. We will engineer and apply tools and models to measure and manipulate this crucial cellular mechanism. This will allow us to predict disease severity as well as to intervene where a manipulation of this mechanism will be beneficial.
Industrial Transformation Training Centres - Grant ID: IC170100032
Funder
Australian Research Council
Funding Amount
$4,272,072.00
Summary
ARC Training Centre in Fire Retardant Materials and Safety Technologies. The ARC Training Centre in Fire Retardant Materials and Safety Technologies aims to train a cohort of industry-focused researchers to improve the fire safety of lightweight materials and structures and fire protection systems. The Training Centre expects to create knowledge on novel green and durable fire retardant materials, advanced fire models for urban and built environment, fire suppression technologies, and new flamma ....ARC Training Centre in Fire Retardant Materials and Safety Technologies. The ARC Training Centre in Fire Retardant Materials and Safety Technologies aims to train a cohort of industry-focused researchers to improve the fire safety of lightweight materials and structures and fire protection systems. The Training Centre expects to create knowledge on novel green and durable fire retardant materials, advanced fire models for urban and built environment, fire suppression technologies, and new flammability tests for compliance with fire safety regulatory standards. An expected outcome of this Training Centre is to accelerate the transformation of Australia’s industries in fire retardant materials, products and engineering services.Read moreRead less
Quantification of heat release, NOx emissions and soot from high temperature gaseous flames. The ongoing importance of Australia's minerals processing sector depends on advanced combustion technology to minimise the emission of NOx and other greenhouse gases. The heat release and NOx emissions from the high temperature flames used in such processes is known to depend strongly on the presence of soot. However their optimisation and design is limited by a lack of fundamental data under relevant c ....Quantification of heat release, NOx emissions and soot from high temperature gaseous flames. The ongoing importance of Australia's minerals processing sector depends on advanced combustion technology to minimise the emission of NOx and other greenhouse gases. The heat release and NOx emissions from the high temperature flames used in such processes is known to depend strongly on the presence of soot. However their optimisation and design is limited by a lack of fundamental data under relevant conditions. To address this need, new measurements and analysis will be performed to quantify the complex relationship between turbulent mixing, soot formation, heat release and NOx emissions under high temperature conditions of both fundamental and practical significance.
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Identification Of Genes For X-linked Mental Retardation.
Funder
National Health and Medical Research Council
Funding Amount
$675,228.00
Summary
We propose to identify novel heritable causes of intellectual disability using 22 large and well-characterised families from Australia. In these families we have refined the location of the genetic defect to the chromosome X and excluded the contribution of all so far known genes. We will achieve this using the technology of massive parallel sequencing. At the completion of the project we will have identified novel causes of intellectual disability and devised tests to identify them.