Time dependent stratified flows in a differentially heated cavity under realistic conditions. Flows driven by the application of a horizontal temperature gradient has applications in nature and engineering. Although much progress has been made in the analysis of the case of a sudden application of temperature differences to the vertical walls of a container with insulating horizontal walls containing an isothermal fluid, the reality is that neither the insulated walls nor the initially isotherma ....Time dependent stratified flows in a differentially heated cavity under realistic conditions. Flows driven by the application of a horizontal temperature gradient has applications in nature and engineering. Although much progress has been made in the analysis of the case of a sudden application of temperature differences to the vertical walls of a container with insulating horizontal walls containing an isothermal fluid, the reality is that neither the insulated walls nor the initially isothermal fluid can be achieved. This project will, by analytical, numerical and experimental methods, make a preliminary investigation of the influence of conducting horizontal walls and an initially stratified fluid.Read moreRead less
Enhancing natural convection heat transfer using a single horizontal non-metallic fin. This project will develop the basis for a simple design to improve the energy efficiency of natural convection heat exchangers. Heat exchangers are widely adopted in many electronic devices and industrial processes as they require no external power input, additional space, and are quiet, reliable and economical. The research will exploit the interaction between two flows to trigger turbulence, and will result ....Enhancing natural convection heat transfer using a single horizontal non-metallic fin. This project will develop the basis for a simple design to improve the energy efficiency of natural convection heat exchangers. Heat exchangers are widely adopted in many electronic devices and industrial processes as they require no external power input, additional space, and are quiet, reliable and economical. The research will exploit the interaction between two flows to trigger turbulence, and will result in an increase of the overall capacity and performance of engineering systems. This will contribute significantly to reductions in power consumption and improvements in productivity and work environment, leading ultimately to reductions in greenhouse gas emissions and to economic benefits.Read moreRead less
Design tools for optimising data centre layout to minimise energy usage. Data centres are major consumers of energy worldwide, mainly through the need to cool the equipment. It has become imperative to develop the science for reducing this consumption. Rising computing demand, increasing power density, and increasing infrastructure and energy costs are major issue for data centres around the world. Our research will provide a powerful alternative to conventional thermal management techniques for ....Design tools for optimising data centre layout to minimise energy usage. Data centres are major consumers of energy worldwide, mainly through the need to cool the equipment. It has become imperative to develop the science for reducing this consumption. Rising computing demand, increasing power density, and increasing infrastructure and energy costs are major issue for data centres around the world. Our research will provide a powerful alternative to conventional thermal management techniques for cooling high-density heat loads in mixed-density environments. We will address the key issue of energy minimisation through a detailed flow analyses by the use of numerical simulations and optimisation algorithms.Read moreRead less
Modelling of unsteady natural convection in a reservoir sidearm. Horizontal exchange flows induced by daytime heating and night-time cooling through water surface play an important role in the transport of water properties in the shoreline regions of reservoirs. This project is aimed at exploring the driving mechanisms of these flows through a closely linked experimental, numerical and analytical research program. At the completion of this project, significant advance in experimental methodology ....Modelling of unsteady natural convection in a reservoir sidearm. Horizontal exchange flows induced by daytime heating and night-time cooling through water surface play an important role in the transport of water properties in the shoreline regions of reservoirs. This project is aimed at exploring the driving mechanisms of these flows through a closely linked experimental, numerical and analytical research program. At the completion of this project, significant advance in experimental methodology will be achieved, and reliable experimental and theoretical data will be available that can be used to estimate the heat and mass transfer in the coastal regions which is important for water quality management and environmental planning.Read moreRead less
Integrating Immunity And Genetics In Follicular Lymphoma To Establish A Prognostic Score Fit For The Modern Era
Funder
National Health and Medical Research Council
Funding Amount
$1,377,174.00
Summary
Follicular lymphoma (FL) is divided into early and advanced stages. Early stage FL is frequently cured, but there is no way to identify who will be cured and who won't. By contrast advanced stage FL is incurable. Our unique access to well-annotated clinical trial and population based cohorts allows us to perform a detailed biological comparison of early and advanced FL, to gain a deeper understanding of the impediments to eradicating the disease, and to predict outcome to conventional therapy.
Natural convection induced exchange flows between near shore and central regions of reservoirs. Inland discharges into reservoirs often carry rich nutrients, pollutants and biological species into the coastal regions, which are redistributed across the central regions of reservoirs through dynamical mixing processes. One of the important mixing processes is the horizontal exchange flow between the near shore and central regions induced by diurnal heating and cooling through the water surface, wh ....Natural convection induced exchange flows between near shore and central regions of reservoirs. Inland discharges into reservoirs often carry rich nutrients, pollutants and biological species into the coastal regions, which are redistributed across the central regions of reservoirs through dynamical mixing processes. One of the important mixing processes is the horizontal exchange flow between the near shore and central regions induced by diurnal heating and cooling through the water surface, which is classified as a natural convection process. This process will be investigated in this project through a closely linked analytical, experimental and numerical research program. The output from this research will have direct application in water quality management and environmental planning.Read moreRead less
Transport by Natural Convection in Reservoir Sidearms. This project is a first step in developing models of the distribution of water quality parameters in reservoirs by a range of small scale dynamical processes not included in commercial water quality models. Specifically, the project will investigate the transport of suspended materials from the shore to the deeper parts resulting from the interaction of the meteorological forcing and the topography. This will contribute to the development of ....Transport by Natural Convection in Reservoir Sidearms. This project is a first step in developing models of the distribution of water quality parameters in reservoirs by a range of small scale dynamical processes not included in commercial water quality models. Specifically, the project will investigate the transport of suspended materials from the shore to the deeper parts resulting from the interaction of the meteorological forcing and the topography. This will contribute to the development of improved water quality models, and therefore to better management of water quality of Australia's water resources.Read moreRead less
Genome-wide Association Studies Of Biomedical Traits And Endophenotypes For Complex Disease
Funder
National Health and Medical Research Council
Funding Amount
$295,804.00
Summary
The burden of common complex diseases, such as cardiovascular disease is substantial to the health care system. These diseases are caused by genes and environments as well as their interactions. The proposed project will identify genes affecting the susceptibility of individuals to complex diseases. Discovery of such genes will be important for their diagnosis, prevention and treatment and may serve as an important resource for future personalized medicine.
Structural And Functional Analysis Of A Cancer-linked Co-regulator Complex
Funder
National Health and Medical Research Council
Funding Amount
$729,571.00
Summary
We seek to understand the mechanisms by which genes are switched on and off throughout our lifetime. A number of multi-component protein machines are involved in this process but their make-up and mechanism of action is not understood. We will investigate the structure and function of one of these machines that has been strongly linked to cancer.
Most eye diseases have a genetic contribution, whether rare disorders affecting children such as retinoblastoma or congenital cataracts through to common disorders of older people such as myopia, age-related macular degeneration or glaucoma. We will continue our successful research to find genes that cause these diseases and use this to improve patient care and prevent blindness. We will work out how families can use this genetic information to participate in trials to develop new treatments.