Novel Statistical Methods For Genetic Epidemiology
Funder
National Health and Medical Research Council
Funding Amount
$481,505.00
Summary
We are in the midst of a genomics revolution that is transforming epidemiology, medicine and drug discovery. However, the scarcity of sophisticated statistical techniques to deal with the complicated problems inherent in genetic investigations of complex diseases is currently the critical factor limiting the success of human gene discovery programs. Statistical genetic methodology is currently one of the fastest developing areas of epidemiology. In information-intensive' areas such as genetic ep ....We are in the midst of a genomics revolution that is transforming epidemiology, medicine and drug discovery. However, the scarcity of sophisticated statistical techniques to deal with the complicated problems inherent in genetic investigations of complex diseases is currently the critical factor limiting the success of human gene discovery programs. Statistical genetic methodology is currently one of the fastest developing areas of epidemiology. In information-intensive' areas such as genetic epidemiology, genomics, and proteomics, there is a high demand for data analysis and statistical skills. WA has some world class expertise in statistical science, both in academia and in industry. However, this expertise has not yet been applied in a system way to genetic data analysis. We propose to undertake advanced methodological research in statistical genetics and bioinformatics, to produce easy-to-use and accessible software tools and resources that allow methodological advances to be accessed by the Australian research community, and to apply our new methods and tools both to specific disease research and to the developing human genome epidemiology (HuGE) enterprise in WA. These new initiatives in methodological research will draw together a number of currently separate research strands and will provide new tools and resources that will allow applied Australian programs to improve the efficiency of their research into the causes of important. Methodological development in both bioinformatics and statistical genetics are recognized international areas of need.Read moreRead less
Preventing Exfiltration of Sensitive Data by Malicious Insiders or Malwares. Data exfiltration is a serious threat as highlighted in recent leakage of sensitive data that resulted in huge economic losses as well as unprecedented breaches of national security. The aim of this project is to develop a comprehensive and robust solution for detection and prevention of sensitive data exfiltration attempts by malware and unauthorised human users. Expected outcomes include scalable monitoring methods an ....Preventing Exfiltration of Sensitive Data by Malicious Insiders or Malwares. Data exfiltration is a serious threat as highlighted in recent leakage of sensitive data that resulted in huge economic losses as well as unprecedented breaches of national security. The aim of this project is to develop a comprehensive and robust solution for detection and prevention of sensitive data exfiltration attempts by malware and unauthorised human users. Expected outcomes include scalable monitoring methods and efficient algorithms that will be able to prevent real-time exfiltration and identify previously undetected exfiltration of sensitive data. This should provide significant benefits to governments, defence networks as well as businesses and health sectors, as it will protect them from sophisticated cyber attacks.
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Discovery Early Career Researcher Award - Grant ID: DE120101266
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Low-complexity factor-graph-based receiver design for bandwidth-efficient communication systems over doubly selective channels. This project aims to solve challenging problems in future wireless communications using graph-based signal processing techniques. It will provide practical solutions for future broadband mobile communications to the bush and high-speed underwater acoustic communications in the oceans that are particularly important to Australia.
Optimal Control Computation and Analysis of Switched Systems with State and Control Constraints. DC/DC converters are widely used in power supply systems and hybrid power systems generate cleaner energy. Achieving optimum performance in these applications has high commercial and environmental impacts. New optimal control problems for such practical problems will be formulated and new unified optimization theory and methods for these optimal control problems will be obtained. The outcomes will en ....Optimal Control Computation and Analysis of Switched Systems with State and Control Constraints. DC/DC converters are widely used in power supply systems and hybrid power systems generate cleaner energy. Achieving optimum performance in these applications has high commercial and environmental impacts. New optimal control problems for such practical problems will be formulated and new unified optimization theory and methods for these optimal control problems will be obtained. The outcomes will enhance Australia's reputation in this cutting edge research, and contribute to achieving optimal performance of high commercial and environmental value applications. It will also facilitate international collaboration, and provide an excellent opportunity for research training.Read moreRead less
Blind separation of mutually correlated sources. This project is aimed at developing novel techniques for blind separation of mutually correlated sources. The expected outcomes will significantly advance the theory of blind source separation and improve the performance of important practical systems, such as densely deployed sensor networks and wireless video surveillance systems.
A Study of Stabilisation and Optimal Control Computation of Impulsive Control Systems. Impulsive systems exhibit the phenomenon of jumps occurring at various time points along their trajectories. They arise from many applications, such as determining appropriate levels of drug administration in cancer and diabetes treatment, optimizing investment strategies in capacity expansion, and sustainable optimal forest management. This project will result in fundamental theory on stability and efficient ....A Study of Stabilisation and Optimal Control Computation of Impulsive Control Systems. Impulsive systems exhibit the phenomenon of jumps occurring at various time points along their trajectories. They arise from many applications, such as determining appropriate levels of drug administration in cancer and diabetes treatment, optimizing investment strategies in capacity expansion, and sustainable optimal forest management. This project will result in fundamental theory on stability and efficient computational algorithms and software packages for stabilizing controls and optimal controls of impulsive control problems. The outcomes will enhance Australia's reputation for leading edge research and facilitate opportunity for international collaboration. It will also provide an excellent opportunity for research training.Read moreRead less
Advances in Conformal Field Theory with Extended Symmetry. This project aims to develop novel methods to formulate conformal field theories with extended symmetry that are important in variety of applications ranging from pure mathematics to phenomenology of elementary particles. The project expects to advance our knowledge in the most challenging areas of modern theoretical physics - Quantum Gravity and physics beyond the Standard Model of particle physics. Its expected outcomes will include co ....Advances in Conformal Field Theory with Extended Symmetry. This project aims to develop novel methods to formulate conformal field theories with extended symmetry that are important in variety of applications ranging from pure mathematics to phenomenology of elementary particles. The project expects to advance our knowledge in the most challenging areas of modern theoretical physics - Quantum Gravity and physics beyond the Standard Model of particle physics. Its expected outcomes will include conceptual results of major significance for modern theoretical and mathematical physics, thus placing Australia at the forefront of this research. A rich intellectual environment will be provided for training Australian PhD students by internationally recognised experts.
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Novel Conformal Techniques in Quantum Field Theory, Gravity and Supergravity. Conformal symmetry is the maximal spacetime symmetry in relativistic quantum theory. This project will explore the dynamics of those quantum field theories and matter-coupled gravity theories that possess conformal symmetry and have recently been the focus of enormous interest worldwide. Its scientific outcomes will include a deeper understanding of Wilson loops in Yang-Mills theories, scattering amplitudes in conforma ....Novel Conformal Techniques in Quantum Field Theory, Gravity and Supergravity. Conformal symmetry is the maximal spacetime symmetry in relativistic quantum theory. This project will explore the dynamics of those quantum field theories and matter-coupled gravity theories that possess conformal symmetry and have recently been the focus of enormous interest worldwide. Its scientific outcomes will include a deeper understanding of Wilson loops in Yang-Mills theories, scattering amplitudes in conformal gravity and supergravity as well as other conceptual results of major importance to modern mathematical physics, thus placing Australia at the forefront of this research. A rich intellectual environment will be provided for training of Australian PhD students by internationally recognised experts. Read moreRead less
Conformal Field Theories with Higher Spin Symmetry and Duality Invariance. This project aims to develop novel methods to study conformal field theories with higher spin symmetry and duality invarianvce that are important in variety of applications ranging from cosmology to phenomenology of elementary particles. The project expects to advance our knowledge in one of the most challenging areas of modern theoretical physics - Quantum Gravity and physics beyond the Standard Model of particle physics ....Conformal Field Theories with Higher Spin Symmetry and Duality Invariance. This project aims to develop novel methods to study conformal field theories with higher spin symmetry and duality invarianvce that are important in variety of applications ranging from cosmology to phenomenology of elementary particles. The project expects to advance our knowledge in one of the most challenging areas of modern theoretical physics - Quantum Gravity and physics beyond the Standard Model of particle physics. Its expected outcomes will be new conceptual results of major significance for modern theoretical and mathematical physics, thus placing Australia at the forefront of this research. Benefits will include a rich intellectual environment for training Australian PhD students by internationally recognised experts.
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Advances in HIgher Spin Gauge Theory. This project aims to explore the dynamical and geometrical aspects of higher spin gauge theory that have recently become the focus of enormous interest worldwide. Higher spin gauge theory is a unique generalisation of Einstein’s gravitation theory, which possesses maximal gauge symmetry and is a novel candidate for quantum gravity. Expected project outcomes include a better understanding of higher-spin interaction vertices, correlation functions, and other c ....Advances in HIgher Spin Gauge Theory. This project aims to explore the dynamical and geometrical aspects of higher spin gauge theory that have recently become the focus of enormous interest worldwide. Higher spin gauge theory is a unique generalisation of Einstein’s gravitation theory, which possesses maximal gauge symmetry and is a novel candidate for quantum gravity. Expected project outcomes include a better understanding of higher-spin interaction vertices, correlation functions, and other conceptual results of major importance to mathematical physics.Read moreRead less